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High-throughput screening methods provide efficient measurement of the effects of agents or conditions in biological or chemical assays. These methods often require robotics, imaging and computation to increase the scale and speed of assays.
There is a need for Plasmodium transmission blocking drugs for malaria elimination. Here, Miguel-Blanco et al. screen >10,000 compounds against stage V female gametocytes, identify active compounds belonging to 57 chemotypes and confirm transmission blocking activity of four selected compounds in vitro.