Different gut microbial metabolites have the potential to promote and protect against colorectal cancer (CRC). A study now links trans-3-indoleacrylic acid (IDA), a metabolite derived from Peptostreptococcus anaerobius, with colorectal carcinogenesis through a distinct ferroptosis pathway AHR–ALDH1A3–FSP1–CoQ10.
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References
Villemin, C. et al. Trends Immunol. 44, 44–59 (2023).
Louis, P., Hold, G. L. & Flint, H. J. Nat. Rev. Microbiol. 12, 661–672 (2014).
Beyaz, S. et al. Cell Stem Cell 28, 1922–1935.e5 (2021).
Cui, W. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01314-6 (2023).
Hezaveh, K. et al. Immunity 55, 324–340.e8 (2022).
Heath-Pagliuso, S. et al. Biochemistry 37, 11508–11515 (1998).
Bersuker, K. et al. Nature 575, 688–692 (2019).
Doll, S. et al. Nature 575, 693–698 (2019).
Chen, Z. et al. Cell Death Dis. 14, 460 (2023).
Deng, F. et al. Gut Microbes 13, 1–21 (2021).
Fiore, A. et al. Mol. Cell 82, 920–932.e7 (2022).
Smith, P. M. et al. Science 341, 569–573 (2013).
Bender, M. J. et al. Cell 186, 1846–1862.e26 (2023).
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Zhang, Q., Goswami, S. & Yilmaz, O. Microbial regulation of ferroptosis in cancer. Nat Cell Biol 26, 41–42 (2024). https://doi.org/10.1038/s41556-023-01321-7
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DOI: https://doi.org/10.1038/s41556-023-01321-7
