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Organelles

Sperm bud mitochondria to adjust the numbers

Cells use diverse mechanisms to rid themselves of dysfunctional or excess mitochondria. A study now shows that C. elegans sperm use a previously undescribed mechanism to rapidly expel single healthy mitochondria in membrane-bound structures called mitophers.

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Fig. 1: Mitophers enable sperm to downsize their mitochondrial pool.

References

  1. Park, Y. J. & Pang, M. G. Antioxidants 10, 98 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Onishi, M. et al. EMBO J. 40, E104705 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Melentijevic, I. et al. Nature 542, 367–371 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Jiang, Y. et al. Cell Commun. Signal 21, 105 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Lv, C. et al. Cells 23, 2523 (2020).

    Article  Google Scholar 

  6. Winter, E. S. et al. Development 144, 3253–3263 (2017).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Liu, P. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01264-z (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Ellis, R. E. & Stanfield, G. M. Semin Cell Dev Biol. 29, 17–30 (2014).

    Article  CAS  PubMed  Google Scholar 

  9. Vielle, A. et al. Evolution 70, 2485–2503 (2016).

    Article  PubMed  Google Scholar 

Download references

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Correspondence to Diane C. Shakes.

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Shakes, D.C. Sperm bud mitochondria to adjust the numbers. Nat Cell Biol 25, 1564–1565 (2023). https://doi.org/10.1038/s41556-023-01255-0

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