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Nuclear envelope

A diffusion barrier limits nuclear leaks

Nature Cell Biology volume 25, pages 1411–1412 (2023)Cite this article

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ESCRT-III seals holes in the nuclear envelope (NE). A study now shows that the Cmp7-directed ESCRT-III cascade that grommets and reseals NE holes after spindle pole body (SPB) extrusion at the end of fission yeast mitosis is complemented by the presence of a proteinaceous diffusion barrier to ensure NE integrity.

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Fig. 1: ESCRT-III cooperates with diffusion barriers to seal and repair holes in the NE.

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Authors and Affiliations

  1. Cell Biology and Biophysics, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

    Hiral Shah & Gautam Dey

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  1. Hiral Shah
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  2. Gautam Dey
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Correspondence to Gautam Dey.

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The authors declare no competing interests.

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Shah, H., Dey, G. A diffusion barrier limits nuclear leaks. Nat Cell Biol 25, 1411–1412 (2023). https://doi.org/10.1038/s41556-023-01243-4

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