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Cell death

Nonmetabolic role for CKB in ferroptosis

Nature Cell Biology volume 25, pages 633–634 (2023)Cite this article

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The selenoprotein glutathione peroxidase 4 (GPX4) is the guardian of ferroptosis, a form of cell death earmarked by unrestrained lipid peroxidation. A new study shows that the metabolic enzyme creatinine kinase B (CKB) phosphorylates GPX4, which may influence the susceptibility of cancer cells to ferroptosis.

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Fig. 1: The CKB–GPX4 phosphorylation axis.

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Authors and Affiliations

  1. Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Munich, Germany

    Eikan Mishima & Marcus Conrad

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  1. Eikan Mishima
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  2. Marcus Conrad
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Correspondence to Marcus Conrad.

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Competing interests

M.C. is co-founder and shareholder of ROSCUE Therapeutics GmbH. E.M. declares no competing interests.

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Mishima, E., Conrad, M. Nonmetabolic role for CKB in ferroptosis. Nat Cell Biol 25, 633–634 (2023). https://doi.org/10.1038/s41556-023-01104-0

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