Programmed cell death (PCD) enables cells to co-ordinate their exit to benefit the surviving organism. A new study describes how cells can programme their death by inducing extensive disulfide bonding of the actin cytoskeleton in response to an imbalance of cystine, a raw material for glutathione production.
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Machesky, L.M. Deadly actin collapse by disulfidptosis. Nat Cell Biol 25, 375–376 (2023). https://doi.org/10.1038/s41556-023-01100-4
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DOI: https://doi.org/10.1038/s41556-023-01100-4
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