Caveolin-1 (CAV1) is best known as a building block of caveolae, flask-shaped ‘little caves’ that buffer the plasma membrane by flattening in response to mechanical stress. CAV1 is now linked to a feature of cellular topography that can respond to mechanical cues and relieve membrane tension: dolines.
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References
Parmryd, I. & Onfelt, B. EBS J. 280, 2775–2784 (2013).
Lolo, F.-N. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-022-01034-3 (2022).
Cohen, A. W., Hnasko, R., Schubert, W. & Lisanti, M. P. Physiol. Rev. 84, 1341–1379 (2004).
Parton, R. G. & del Pozo, M. A. Nat. Rev. Mol. Cell Biol. 14, 98–112 (2013).
Parton, R. G., McMahon, K. A. & Wu, Y. Curr. Opin. Cell Biol. 65, 8–16 (2020).
Sinha, B. et al. Cell 144, 402–413 (2011).
Del Pozo, M. A., Lolo, F. N. & Echarri, A. Curr. Opin. Cell Biol. 68, 113–123 (2021).
Hansen, C. G. & Nichols, B. J. Trends Cell Biol. 20, 177–186 (2010).
Bhattachan, P. et al. FASEB J. 34, 1345–1361 (2020).
Khater, I. M., Meng, F., Wong, T. H., Nabi, I. R. & Hamarneh, G. Sci. Rep. 8, 9009 (2018).
Hong, A. W. et al. EMBO Rep. 18, 72–86 (2017).
Gould, M. L., Williams, G. & Nicholson, H. D. Prostate 70, 1609–1621 (2010).
Head, B. P. & Insel, P. A. Trends Cell Biol. 17, 51–57 (2007).
Porta, J. C. et al. Sci. Adv. 8, eabn7232 (2022).
Kirkham, M. et al. J. Cell Sci. 121, 2075–2086 (2008).
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Kenworthy, A.K. Cellular sinkholes buffer membrane tension. Nat Cell Biol 25, 15–16 (2023). https://doi.org/10.1038/s41556-022-01032-5
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DOI: https://doi.org/10.1038/s41556-022-01032-5