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Substoichiometric action of long noncoding RNAs

Nature Cell Biology volume 24, pages 608–615 (2022)Cite this article

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Abstract

Low expression levels and stoichiometric imbalances of long noncoding RNAs (lncRNAs) are often used as evidence for their probable lack of function or for limiting the scope of their potential influence. Recent advances in our understanding of the substoichiometric functions of lncRNAs challenge these notions and suggest routes through which unabundant lncRNAs can affect cellular functions and gene regulatory networks.

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Fig. 1: The lncRNAs NORAD and Xist induce phase transitions with distinct regulatory functions.
Fig. 2: ncRNAs are essential for the formation and function of nuclear concentration gradients.
Fig. 3: The lncRNAs Cyrano and SLERT are recycled to modify a supra-stoichiometric number of targets.

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Acknowledgements

J.P.U. is a recipient of the Azrieli International Postdoctoral Fellowship from the Azrieli Foundation, the Excellence Fellowship Program for International Postdoctoral Researchers from the Council for Higher Education & Israel Academy of Sciences & Humanities, and an EMBO Non-Stipendiary Postdoctoral Fellowship from the European Molecular Biology Organization.

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  1. Departments of Biological Regulation and Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel

    Juan Pablo Unfried & Igor Ulitsky

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Correspondence to Juan Pablo Unfried or Igor Ulitsky.

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Unfried, J.P., Ulitsky, I. Substoichiometric action of long noncoding RNAs. Nat Cell Biol 24, 608–615 (2022). https://doi.org/10.1038/s41556-022-00911-1

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