Increased tRNA abundance and amino acid coupling generally promote increased oncogenesis. By contrast, a new study shows that in breast cancer, the leucyl-tRNA synthetase LARS suppresses transformation and tumour development by increasing tRNA-LeuCAG translation of certain tumour suppressor mRNAs.
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Vincent, C.T., Schneider, R.J. Selective tRNA charging in breast cancer. Nat Cell Biol 24, 287–289 (2022). https://doi.org/10.1038/s41556-022-00863-6
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DOI: https://doi.org/10.1038/s41556-022-00863-6
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