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Stem Cells

Tracheal remodelling supports stem cells

The vascular system, plastic and positioned in the vicinity of tissues, is an undervalued regulator of adult stem cells. Two studies now show that the vascular-like Drosophila trachea is reshaped after intestinal damage or tumour formation and that this remodelling is required for compensatory intestinal stem cell proliferation and tumour growth.

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Fig. 1: Schematic of the dialogue between the intestinal epithelium and the tracheal system in homeostasis, infection, cancer and hypoxia.

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Correspondence to Louis Gervais or Allison J. Bardin.

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Gervais, L., Bardin, A.J. Tracheal remodelling supports stem cells. Nat Cell Biol 23, 580–582 (2021). https://doi.org/10.1038/s41556-021-00695-w

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