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GENOME STABILITY

MSL pushes genomic instability over the edge

Chromosomal instability (CIN) is a hallmark of malignant evolution that underpins cancer progression and therapeutic evasion. There are few established experimental systems to study CIN and ultimately develop potential therapeutic options. A new study now identifies the MSL chromatin complex as a potential vulnerability against CIN in cancer cells.

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Fig. 1: Role of the MSL complex in tumour cell maintenance.

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Correspondence to Mark A. Dawson.

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M.A.D. has been a member of advisory boards for GlaxoSmithKline, CTX CRC, Storm Therapeutics, Celgene and Cambridge Epigenetix. The M.A.D. laboratory received research funding from CTx CRC.

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Motazedian, A., Dawson, M.A. MSL pushes genomic instability over the edge. Nat Cell Biol 23, 295–296 (2021). https://doi.org/10.1038/s41556-021-00666-1

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