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Condensing and constraining WNT by TGF-β

TGF-β can antagonise or cooperate with WNT signalling, yet it is still unclear what mechanisms integrate the outcomes of these conserved pathways. A new study now reports that the formation of biomolecular condensates, dependent on the DACT1 protein, provides the spatial segregation needed for TGF-β to constrain WNT signalling.

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Fig. 1: Activation of canonical WNT and TGF-β receptors lead to distinct, but integrated downstream signalling pathways.


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Correspondence to Don X. Nguyen.

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D.X.N. has received research support from AstraZeneca, Inc.

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Patel, K.D., Nguyen, D.X. Condensing and constraining WNT by TGF-β. Nat Cell Biol 23, 213–214 (2021).

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