Circular RNAs regulate a variety of biological processes. Now an unexpected pathway is revealed in which a translated circular RNA derived from E-cadherin pre-mRNA activates EGFR signalling in glioblastoma cancer stem cells and acts as a ligand for the EGFR mutant EGFRVIII, a common oncogenic variant.
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Mitchell, K., Lathia, J.D. A circuitous route to GBM stem cell signalling. Nat Cell Biol 23, 211–212 (2021). https://doi.org/10.1038/s41556-021-00643-8
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DOI: https://doi.org/10.1038/s41556-021-00643-8