CANCER

Optimising gene editing for cancer therapy

Gene editing holds promise for the treatment of cancers that are driven by well-characterised molecular alterations. A study now provides a proof of concept for the feasibility of in vivo gene editing to correct TERT mutations in glioblastoma, providing a platform for the direct manipulation of genetic alterations to reduce tumour growth.

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Fig. 1: TERT promoter activity in glioblastoma tumour cells.

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Correspondence to Justin D. Lathia.

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Troike, K., Lathia, J.D. Optimising gene editing for cancer therapy. Nat Cell Biol 22, 259–261 (2020). https://doi.org/10.1038/s41556-020-0480-5

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