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EPIGENETICS

Many XCI-ting routes to reach the eXACT dose

X-chromosome inactivation studies have revealed striking species specificities in terms of the players, kinetics and mechanisms. Transcriptomic profiling of human pre‐implantation development and germ cell differentiation suggests a peculiar dosage compensation mechanism with yet undefined contributions from XIST and XACT lncRNAs.

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Fig. 1: Models for X-chromosome activity control during human development.

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Correspondence to Claire Rougeulle.

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Ouimette, JF., Rougeulle, C. Many XCI-ting routes to reach the eXACT dose. Nat Cell Biol 22, 1397–1398 (2020). https://doi.org/10.1038/s41556-020-00608-3

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