Development

Endothelial cells revealed as chondroclasts

Osteoclasts are known for their role in bone resorption. A study now shows that a vascular–associated osteoclast subtype at the growth plate also regulates blood vessel growth in bone and is supported by type H endothelial cells. These type H capillaries, in turn, release proteinases that promote cartilage degradation.

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Fig. 1: The supportive and destructive functions of type H endothelial cells.

References

  1. 1.

    Zaidi, M. & Iqbal, J. Nat. Med. 22, 460–461 (2016).

    CAS  Article  Google Scholar 

  2. 2.

    Zaidi, M. Nat. Med. 13, 791–801 (2007).

    CAS  Article  Google Scholar 

  3. 3.

    Sara, G. Nat. Cell Biol.. https://doi.org/10.1038/s41556-019-0304-7 (2019).

    Article  Google Scholar 

  4. 4.

    Ramasamy, S. K. Stem Cells Int. 2017, 5046953 (2017).

    Article  Google Scholar 

  5. 5.

    Ramasamy, S. K. et al. Annu. Rev. Cell Dev. Biol. 32, 649–675 (2016).

    CAS  Article  Google Scholar 

  6. 6.

    Iqbal, J. & Zaidi, M. Biochem. Biophys. Res. Commun. 328, 751–755 (2005).

    CAS  Article  Google Scholar 

  7. 7.

    Vu, T. H. et al. Cell 93, 411–422 (1998).

    CAS  Article  Google Scholar 

  8. 8.

    Aiken, A. & Khokha, R. Biochim. Biophys. Acta 121–132, 2010 (1803).

    Google Scholar 

  9. 9.

    Schenk, R. K., Wiener, J. & Spiro, D. Acta Anat. 69, 1–17 (1968).

    CAS  Article  Google Scholar 

  10. 10.

    Maes, C. & Clemens, T. L. Bonekey Rep. 3, 578 (2014).

    CAS  Article  Google Scholar 

  11. 11.

    Savostin-Asling, I. & Asling, C. W. Anat. Rec. 183, 373–391 (1975).

    CAS  Article  Google Scholar 

  12. 12.

    Rose, B. J. & Kooyman, D. L. Dis. Markers 2016, 4895050 (2016).

    Article  Google Scholar 

  13. 13.

    Ramasamy, S. K. et al. Nat. Commun. 7, 13601 (2016).

    Article  Google Scholar 

  14. 14.

    Alam, A. S. et al. Endocrinology 130, 3617–3624 (1992).

    CAS  Article  Google Scholar 

  15. 15.

    MacIntyre, I. et al. Proc. Natl Acad. Sci. USA 88, 2936–2940 (1991).

Download references

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Correspondence to Mone Zaidi.

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Iqbal, J., Zaidi, M. Endothelial cells revealed as chondroclasts. Nat Cell Biol 21, 417–419 (2019). https://doi.org/10.1038/s41556-019-0306-5

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