News & Views | Published:

CANCER

Grasping for aspartate in tumour metabolism

Nature Cell Biologyvolume 20pages738739 (2018) | Download Citation

The metabolic phenotype of tumours is shaped by a complex interplay between cancer cells and their microenvironment. Two studies now show that aspartate acquisition is a metabolic limitation encountered by certain tumours in their native in vivo environment, and that overcoming this limitation is advantageous for tumour growth.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Lyssiotis, C. A. & Kimmelman, A. C. Trends Cell Biol. 27, 863–875 (2017).

  2. 2.

    Vander Heiden, M. G. & DeBerardinis, R. J. Cell 168, 657–669 (2017).

  3. 3.

    Garcia-Bermudez, J. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0118-z (2018).

  4. 4.

    Sullivan, L. B. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0125-z (2018).

  5. 5.

    Birsoy, K. et al. Cell 162, 540–551 (2015).

  6. 6.

    Sullivan, L. B. et al. Cell 162, 552–563 (2015).

  7. 7.

    Mayers, J. R. & Vander Heiden, M. G. Trends Biochem. Sci. 40, 130–140 (2015).

  8. 8.

    Krall, A. S., Xu, S., Graeber, T. G., Braas, D. & Christofk, H. R. Nat. Commun. 7, 11457 (2016).

  9. 9.

    Zhang, J. et al. Mol. Cell 56, 205–218 (2014).

  10. 10.

    Gui, D. Y. et al. Cell Metab. 24, 716–727 (2016).

  11. 11.

    Rabinovich, S. et al. Nature 527, 379–383 (2015).

  12. 12.

    Commisso, C. et al. Nature 497, 633–637 (2013).

  13. 13.

    Davidson, S. M. et al. Nat. Med. 23, 235–241 (2017).

  14. 14.

    Cardaci, S. et al. Nat. Cell Biol. 17, 1317–1326 (2015).

  15. 15.

    Sellers, K. et al. J. Clin. Invest. 125, 687–698 (2015).

Download references

Author information

Affiliations

  1. Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA

    • Accalia Fu
    •  & Nika N. Danial

Authors

  1. Search for Accalia Fu in:

  2. Search for Nika N. Danial in:

Corresponding author

Correspondence to Nika N. Danial.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/s41556-018-0137-9

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing