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Pro-tumorigenic AMPK in glioblastoma

Nature Cell Biologyvolume 20pages736737 (2018) | Download Citation

AMPK is a key metabolic sensor promoting cellular energy homeostasis under low-nutrient conditions and other stresses. However, its role in cancer is context-dependent and not fully understood. A study now shows that glioma stem cells co-opt an AMPK-dependent pathway to rewire metabolism, promoting tumour growth.

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Author information

Affiliations

  1. Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

    • Nektaria Maria Leli
    •  & Constantinos Koumenis

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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Constantinos Koumenis.

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DOI

https://doi.org/10.1038/s41556-018-0129-9

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