Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Mechanopathology

Bone mineral slows down breast cancer cells

In breast cancer metastasized to bone, the mineralization of collagen regulates integrin-mediated mechanosignalling, inducing a less proliferative phenotype in breast cancer cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Collagen mineralization regulates the phenotypes of breast cancer cells in bone metastases.

References

  1. Zhang, Y. et al. N. Engl. J. Med. 336, 611–617 (1997).

    Article  CAS  PubMed  Google Scholar 

  2. Zmuda, J. M. et al. J. Natl Cancer Inst. 93, 930–936 (2001).

    Article  CAS  PubMed  Google Scholar 

  3. Kraemer, B. et al. Anticancer Res. 31, 4423–4428 (2011).

    CAS  PubMed  Google Scholar 

  4. Chen, H. M., Chen, F. P., Yang, K. C. & Yuan, S. S. JAMA Netw. Open 2, e190429 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Choi, S. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-023-01077-3 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Esposito, M., Guise, T. & Kang, Y. Cold Spring Harb. Perspect. Med. 8, a031252 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Schrader, J. et al. Hepatology 53, 1192 (2011).

    Article  CAS  PubMed  Google Scholar 

  8. Fattet, L. et al. Dev. Cell 54, 302–316.e7 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Seref-Ferlengez, Z. et al. PLoS ONE 11, e0155107 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Laranga, R. et al. Cancers 12, 2315 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Aponte, P. M. & Caicedo, A. Stem Cells Int. 2017, 5619472 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Talukdar, S. et al. Proc. Natl Acad. Sci. USA 115, 5768–5773 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hai Wang.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ernst, C., Wang, H. Bone mineral slows down breast cancer cells. Nat. Biomed. Eng 7, 1346–1347 (2023). https://doi.org/10.1038/s41551-023-01122-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-023-01122-1

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer