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NEUROMODULATION

Multifunctional optofluidic brain probes

Smartphone-controlled optofluidic neural implants with replaceable and replenishable plug-like drug cartridges enable the selective wireless manipulation of brain circuits in rodents via chronic pharmacology and photostimulation.

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Fig. 1: Refillable optofluidic brain implants for neuromodulation.
Fig. 2: Potential integration of optofluidic brain probes and other diagnostic and drug-delivery systems.

References

  1. 1.

    Rascol, O. et al. Ann. Neurol. 53, S3–S15 (2003).

    CAS  Article  Google Scholar 

  2. 2.

    Renz, A. F., Reichmuth, A. M., Stauffer, F., Thompson-Steckel, G. & Vörös, J. J. Neural Eng. 15, 061001 (2018).

    Article  Google Scholar 

  3. 3.

    Kim, T.-I. et al. Science 340, 211–216 (2013).

    CAS  Article  Google Scholar 

  4. 4.

    Jiang, Y. W. et al. Nat. Biomed. Eng. 2, 508–521 (2018).

    CAS  Article  Google Scholar 

  5. 5.

    Parameswaran, R. et al. Nat. Nanotechnol. 13, 260–266 (2018).

    CAS  Article  Google Scholar 

  6. 6.

    Zimmerman, J. F. & Tian, B. ACS Nano 12, 4086–4095 (2018).

    CAS  Article  Google Scholar 

  7. 7.

    Canales, A. et al. Nat. Biotechnol. 33, 277–284 (2015).

    CAS  Article  Google Scholar 

  8. 8.

    Park, S. et al. Nat. Neurosci. 20, 612–619 (2017).

    CAS  Article  Google Scholar 

  9. 9.

    Qazi, R. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-019-0432-1 (2019).

  10. 10.

    Jeong, J.-W. et al. Cell 162, 662–674 (2015).

    CAS  Article  Google Scholar 

  11. 11.

    Liu, J. et al. Nat. Nanotechnol. 10, 629–636 (2015).

    CAS  Article  Google Scholar 

  12. 12.

    Herisson, F. et al. Nat. Neurosci. 21, 1209–1217 (2018).

    CAS  Article  Google Scholar 

Download references

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Correspondence to John F. Zimmerman or Bozhi Tian.

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Zimmerman, J.F., Tian, B. Multifunctional optofluidic brain probes. Nat Biomed Eng 3, 596–597 (2019). https://doi.org/10.1038/s41551-019-0439-7

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