NEUROMODULATION

Multifunctional optofluidic brain probes

Smartphone-controlled optofluidic neural implants with replaceable and replenishable plug-like drug cartridges enable the selective wireless manipulation of brain circuits in rodents via chronic pharmacology and photostimulation.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Refillable optofluidic brain implants for neuromodulation.
Fig. 2: Potential integration of optofluidic brain probes and other diagnostic and drug-delivery systems.

References

  1. 1.

    Rascol, O. et al. Ann. Neurol. 53, S3–S15 (2003).

  2. 2.

    Renz, A. F., Reichmuth, A. M., Stauffer, F., Thompson-Steckel, G. & Vörös, J. J. Neural Eng. 15, 061001 (2018).

  3. 3.

    Kim, T.-I. et al. Science 340, 211–216 (2013).

  4. 4.

    Jiang, Y. W. et al. Nat. Biomed. Eng. 2, 508–521 (2018).

  5. 5.

    Parameswaran, R. et al. Nat. Nanotechnol. 13, 260–266 (2018).

  6. 6.

    Zimmerman, J. F. & Tian, B. ACS Nano 12, 4086–4095 (2018).

  7. 7.

    Canales, A. et al. Nat. Biotechnol. 33, 277–284 (2015).

  8. 8.

    Park, S. et al. Nat. Neurosci. 20, 612–619 (2017).

  9. 9.

    Qazi, R. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-019-0432-1 (2019).

  10. 10.

    Jeong, J.-W. et al. Cell 162, 662–674 (2015).

  11. 11.

    Liu, J. et al. Nat. Nanotechnol. 10, 629–636 (2015).

  12. 12.

    Herisson, F. et al. Nat. Neurosci. 21, 1209–1217 (2018).

Download references

Author information

Correspondence to John F. Zimmerman or Bozhi Tian.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark