News & Views | Published:

NEUROMODULATION

Non-invasive chemogenetics

Nature Biomedical Engineeringvolume 2pages467468 (2018) | Download Citation

A technique combining focused ultrasound for opening the blood–brain barrier and virally encoded engineered G-protein-coupled receptors for promoting the expression of a gene targeting excitatory neurons enables the non-invasive stimulation of specific brain regions and cell types in mice.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Russo, S. J. & Nestler, E. J. Nat. Rev. Neurosci. 14, 609–625 (2013).

  2. 2.

    Canter, R. G., Penney, J. & Tsai, L. H. Nature 539, 187–196 (2016).

  3. 3.

    Szablowski, J. O., Lee-Gosselin, A., Lue, B., Malounda, D. & Shapiro, M. G. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0258-2 (2018).

  4. 4.

    Roth, B. L. Neuron 89, 683–694 (2016).

  5. 5.

    Sheikov, N., McDannold, N., Vykhodtseva, N., Jolesz, F. & Hynynen, K. Ultrasound Med. Biol. 30, 979–989 (2004).

  6. 6.

    McDannold, N., Clement, G. T., Black, P., Jolesz, F. & Hynynen, K. Neurosurgery 66, 323–332 (2010).

  7. 7.

    First Alzheimer’s trial with focused ultrasound begins. Focused Ultrasound Foundation go.nature.com/2t6hrV9 (2 May 2017).

  8. 8.

    Aschauer, D. F., Kreuz, S. & Rumpel, S. PLoS ONE 8, e76310 (2013).

  9. 9.

    Wang, S., Olumolade, O. O., Sun, T., Samiotaki, G. & Konofagou, E. E. Gene Ther. 22, 104–110 (2015).

  10. 10.

    Izquierdo, I., Furini, C. R. & Myskiw, J. C. Physiol. Rev. 96, 695–750 (2016).

  11. 11.

    Heffner, C. S. et al. Nat. Commun. 3, 1218 (2012).

  12. 12.

    Chan, K. Y. et al. Nat. Neurosci. 20, 1172–1179 (2017).

  13. 13.

    Gomez, J. L. et al. Science 357, 503–507 (2017).

Download references

Author information

Affiliations

  1. Department of Psychiatry and Neuroscience, Faculty of Medicine & CERVO Brain Research Center, Université Laval, Quebec City, Quebec, Canada

    • Caroline Menard
  2. Department of Neuroscience, Center for Affective Neuroscience, and the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA

    • Scott J. Russo

Authors

  1. Search for Caroline Menard in:

  2. Search for Scott J. Russo in:

Corresponding authors

Correspondence to Caroline Menard or Scott J. Russo.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/s41551-018-0269-z

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing