High-throughput screening of large libraries of cyclic peptides expressed in bacteria yields rescuers of the pathogenic misfolding of proteins associated with neurodegenerative diseases.
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References
Gomes, C. M. Curr. Top. Med. Chem. 12, 2460–2469 (2012).
Scheltens, P. et al. The Lancet 388, 505–517 (2016).
Matis, I. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-017-0144-3 (2017).
Scott, C. P., Abel-Santos, E., Wall, M., Wahnon, D. C. & Benkovic, S. J. Proc. Natl Acad. Sci. USA 96, 13638–13643 (1999).
Kaur, S. J., McKeown, S. R. & Rashid, S. Gene 577, 109–118 (2016).
Kinsella, T. M. et al. J. Biol. Chem. 277, 37512–37518 (2002).
Mistry, I. N. & Tavassoli, A. ACS Synth. Biol 6, 518–527 (2016).
Kritzer, J. A. et al. Nat. Methods 5, 655–663 (2009).
Tavassoli, A. Curr. Opin. Chem. Biol. 38, 30–35 (2017).
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Langenberg, T., Schymkowitz, J. & Rousseau, F. Identifying rescuers of misfolding. Nat Biomed Eng 1, 782–783 (2017). https://doi.org/10.1038/s41551-017-0149-y
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DOI: https://doi.org/10.1038/s41551-017-0149-y
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Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding
Nature Communications (2023)