Abstract
The rotation of a C = C bond in an alkene can be efficiently accelerated by creating the high-strain ground state and stabilizing the transition state of the process. Herein, the synthesis, structures, and properties of several highly twisted alkenes are comprehensively explored. A facile and practical synthetic approach to target molecules is developed. The twist angles and lengths of the central C = C bonds in these molecules are 36–58° and 1.40–1.43 Å, respectively, and confirmed by X-ray crystallography and DFT calculations. A quasi-planar molecular half with the π-extended substituents delivers a shallow rotational barrier (down to 2.35 kcal/mol), indicating that the rotation of the C = C bond is as facile as that of the aryl-aryl bond in 2-flourobiphenyl. Other versatile and unique properties of the studied compounds include a broad photoabsorption range (from 250 up to 1100 nm), a reduced HOMO-LUMO gap (1.26–1.68 eV), and a small singlet-triplet energy gap (3.65–5.68 kcal/mol).
Similar content being viewed by others
Introduction
One of the most impressive molecular dynamics among simple alkenes is the restricted rotation of C = C bonds at room temperature. In the rotational process, the transition state (TSrot) is an open-shell singlet diradical with a 90° twisted conformation, and the geometry is virtually identical to that of the lowest-lying triplet state (T1)1. Therefore, the rotational barrier and singlet-triplet gap (ΔEST) are comparable, and those for ethene have been experimentally determined to be 65.9 ± 0.9 kcal/mol2 and 58 ± 3 kcal/mol3, respectively. The key to decreasing the rotational barrier lies in reducing the bond order of the C = C bond4, and this strategy has often been applied in rotary molecular motors for rate acceleration5. In a push-pull alkene, the resonance effect allows the concerned C = C bond to exhibit partial C–C bond character6. For example, dimethyl 2-(N,N-dimethylamino)-2-ethylidenemalonate has a low rotational barrier (ΔG‡rot) of approximately 8.7 kcal/mol (Fig. 1)7. Chichibabin’s hydrocarbon8, which contains a planar backbone, an elongated C = C bond (1.45 Å)9 and remarkable biradical character10, exhibits low ΔEST (calcd. 8.1 kcal/mol)11, and ΔG‡rot (11.4 kcal/mol)12. Sterically overcrowded bianthraquinodimethanes adopt a folded structure with an untwisted C = C bond and a regular bond length13,14, yielding ΔG‡rots exceeding 28 kcal/mol. Several highly twisted alkenes including bi[1,3-bis(dicyanomethylene)indan-2-ylidene]15, perchloro-9,9’-bifluorenylidene16, 13,13’-bis(dibenzo[a,i]fluorenylidene) 1a17 (ΔEST = 3–4 kcal/mol18, or 9.6 kcal/mol19), tetra-n-octoxy-substituted bianthrone (TOBA, ΔEST = 5.7 kcal/mol)20, and tetrafluorenofulvalene (TFF, ΔEST = 1.5 or 3.1 kcal/mol)21 have been investigated but only the last three alkenes are electron spin resonance (ESR) active. The small ΔEST values for twisted TOBA20 and TFF21 are associated with the open-shell ground states whereas that of 1a is related to the high-strain ground state S022,23 and the low-lying T1 state. The latter is stabilized by electron delocalization through the π-system19,24 in addition to hyperconjugation25.
In light of the information mentioned above, the chemistry, structures, molecular dynamics, and properties of a new series of highly strained 13,13’-bis(dibenzo[a,i]fluorenylidenes) 1a–1d (see Fig. 1) and backbone expanded derivatives 2 and 3 are comprehensively explored herein to (1) improve or simplify the synthetic approach that would otherwise be too complicated and inefficient, (2) verify the roles of the π-extended substituents and backbones on the structure-property relationships, and (3) gain in-depth insight into ΔG‡rot (for 1d and 2) and ΔEST using variable-temperature (VT) 1H NMR spectroscopy and a superconducting quantum interference device (SQUID), respectively. Methoxy and 4-tolylethynyl substituents in 1b–1d are located at positions C-5 and C-8 of a DBF fragment (DBF = dibenzo[a,i]fluorene), which both significantly contribute to the frontier orbitals, TSrot, and the T1 state. All studied compounds lie in a core 9,9’-bifluorenylidene (9,9’-BF) structure, whose derivatives are promising candidates for use as electron acceptors in organic optoelectronics26,27,28. The studied 9,9’-BF based compounds were strategically designed and should exhibit interesting electrochemical properties (vide infra). Although the synthesis and some properties of 3 have been reported29, the structure was confirmed for the first time in this study using X-ray crystallography. Importantly, we found that the configurations of two semi-rigid helical substructures significantly affect the structural parameters and properties, which are discussed in the following sections.
Results and discussion
Preparations
The first synthesis of 1a was documented about a century ago using straightforward protocols, such as the reaction of 13,13-dichloro-DBF with copper or heating di(1-naphthyl)carbinol in phosphoric acid30. An alternative approach involves the silver acetate-mediated oxidation of bis(13-dibenzo[a,i]fluorenyl) 7a (61% yield)18,19, which can be generated by thermolysis of 13-[di(1-naphthyl)methyl]-DBF in naphthalene (42%) or radical-mediated dimerization of 13H-DBF 4a (32%)31. Bis(17-tetrabenzo[a,c,g,i]fluorenyl) 9 can be effectively furnished by the titanium-mediated dimerization of pre-isolated 17-litho-TBF (TBF = tetrabenzo[a,c,g,i]fluorene)32. Therefore, a one-pot procedure was developed herein where 7a was directly synthesized from 4a with a yield of 90% (Table 1). Aryl signals of 7a in the 1H NMR spectrum were broad and featureless at room temperature, presumably due to the rocking of the two DBF moieties around the central C–C single bond (Supplementary Fig. 1). Oxidative dehydrogenation of 7a with a mixture of potassium tert-butoxide (tBuOK) and N,N-dimethylformamide (DMF), which acted together as a radical generator33, at 80 °C for 4 h yielded desired product 1a (78%) as a dark green powder. Similarly, 1b, 1c, 1d, 2 and 3 were prepared from 4b, 4c, 4d, 15H-tribenzo[a,c,i]fluorene 5 and 17H-TBF 6 (or 8bH-TBF 10), respectively (see Supplementary Figs. 2 and 3). The critical step was tBuOK-mediated oxidative dehydrogenation, and the reaction conditions were substrate dependent. Notably, treatment of 7a and 9 with n-butyllithium followed by copper(II) chloride34 did not convert them to 1a and 3, respectively. To maximize the chemical yields of 1b (35%) and 1d (43%), oxidative dehydrogenations of 7b and 7d were conducted in dimethyl sulfoxide (DMSO)35 at room temperature for 1 h. Nonetheless, undesired greenish compounds were obtained and confirmed to be the dimeric derivatives of 1b and 1d based on their mass spectra. However, their structures cannot be identified using 1H NMR spectroscopy due to broad and weak resonances. The conversion of methoxy-substituted compound 7c to 1c was very slow, and some of the starting material (approximately 20–30%) remained even after continuing the reaction for 16 h at 80 °C. For the synthesis of 2, the oxidative dehydrogenation of 8 carried out in DMSO (72%) was more effective than that performed in DMF (30%). The highly stable (di)anion species of 9 is most likely responsible for the inefficient formation of 3 (24% yield), and most of the starting material (70%) was recovered36. Except for 3, the aerobic solutions of the studied compounds were stable at room temperature for more than one week.
Structural analysis
The structures of 1a, 1b, 1c, and 3 were verified using single-crystal X-ray crystallography (Supplementary Table 1). The most notable structural parameters were the twist angle (θ1) and length (d) of the central C = C bond, and the first term was verified by the interplanar angle of the two five-membered rings C and C’ (Fig. 2a). The planarization of the DBF moiety was determined by gauging the interplanar angle (θ2) of the two peripheral rings A and A’. Crystals of 1a were composed of two independent molecules that had nearly identical structural parameters (θ1 = approximately 50° and d = 1.40 Å, see Fig. 2b) and slightly bent DBF moieties (θ2 = 10–16°). Substituted derivatives 1b [θ1 = 58°, θ2 = 1° and 5°, d = 1.431(4) Å] and 1c [θ1 = 55°, θ2 = 9° and 15°, d = 1.404(3) Å] are more twisted than 1a but an elongated C = C bond and flat DBF moieties were exclusively observed in the first compound. Compound 3 with a (M,M) configuration (and its enantiomer) was identified, and the interplanar angle of rings D and D’ (defined as θ3) in the helical moiety was 53°, which was accompanied by a highly twisted DBF fragment (θ2 = 39°). The C = C bond in (M,M)-3 was less distorted (θ1 = 36°) and slightly shorter [d = 1.395(3) Å] relative to those of 1a. Intermolecular interactions of these compounds are shown in Supplementary Figs. 4–7. The highly twisted structures of 1b and 1c are most likely associated with the molecular stacking effect because both half fragments of the molecule have intermolecular interactions with neighboring molecules. Although several short intermolecular carbon•••carbon contacts (≤3.40 Å) were observed in the molecular stacking of 1b (Fig. 2c), they should not be the cause of the radical-radical interaction due to the long contact distance (vs. 3.14 Å in a reported example37) and the inconsistency with the spin-density plot (see below).
Computational analysis
Density functional theory [DFT38, (U)B3LYP-D3/6-311 G + + **//6-31 G**] was used to examine the electronic structures, molecular geometries, and rotational dynamics of the studied compounds. Except for 1b, the structures of all compounds obtained by X-ray crystallography were highly consistent with those of the corresponding S0 state (see Supplementary Table 2). The slight inconsistency between the structural parameters for 1b that were obtained experimentally [d = 1.431(4) Å, θ1 = 58°, θ2 = 1° and 5°] and computationally (d = 1.413 Å, θ1 = 52°, θ2 = 14°) is most likely due to perturbations in the intermolecular interactions in the former case, as previously mentioned. Although some functionals suggested that 1b has an open-shell singlet (OS) biradical ground state (Supplementary Tables 3–5), the calculated ΔEST and/or structural parameters d and θ1 strongly disagreed with those observed experimentally. In addition, the bond length d in 1b [exptl. 1.431(4) Å and calcd. 1.413 Å] is remarkably shorter than that in 6,6′-biindeno[1,2‑b]anthracene [d = 1.58(2) Å and 1.495 Å], a biaryl with high diradical character39. syn-1d and anti-1d with nearly identical structural parameters (d = 1.409 Å, θ1 = 51°, θ2 = 14°) are equally stable. S0-2 should contain four conformers when the syn- and anti-conformations as well as the slightly twisted fjord regions are taken into account. These conformers with ordinary structural parameters (θ1 = 46°, 50°; d = 1.402–1.404 Å) must coexist at room temperature due to the barrierless inversion of the fjord region, low ΔH‡rot (3.46 kcal/mol, Table 2), and the tiny energy difference (0.36 kcal/mol) between the most and least stable conformers (Supplementary Fig. 8). (M,M)-3 is the representative diastereomer in this study, and the contributions of (M,P)-3 (ΔH‡rot = 2.65 kcal/mol, ΔHST = 3.51 kcal/mol) should be neglected (Supplementary Fig. 9).
Except for T1-(M,M)-3 (θ1 = 74°, θ2 = 22°), the T1 state of the studied compounds exhibits a perpendicular conformation (θ1 = 86° or 90°) with an elongated bond d (1.462–1.466 Å) and (nearly) planar DBF moieties (θ2 = 0°; 8° for T1-2). The ΔHSTs obtained by DFT calculations are as folows: (M,M)-3 (5.79 kcal/mol, see Table 2) > 1a (5.52 kcal/mol) > 1c (5.41 kcal/mol) > 1d (4.26 kcal/mol) ≈ 2 (4.33 kcal/mol) > 1b (3.19 kcal/mol). The low ΔHSTs for 1b and 1d most likely originate from additional stabilization of π-extended alkynyl moieties on T1-1b and T1-1d, respectively, as shown in their spin density plots (see below and Supplementary Fig. 10). In most cases, the molecular geometries of the TSrot and T1 states are (nearly) identical (see Supplementary Table 2). Structural parameters of (M,M)-3-TSrot (θ1 = 82°, θ2 = 19°, θ3 = 41°, d = 1.462 Å) and T1-(M,M)-3 (θ1 = 74°, θ2 = 22°, θ3 = 42°, d = 1.462 Å) are slightly different, and their DBF moieties are highly twisted. The ΔH‡rots of the studied compounds were determined to be 2.35–5.13 kcal/mol (Table 2), indicating that the rotation of the C = C bond can be as facile as that of an aryl-aryl bond in a simple biphenyl, such as 2-flourobiphenyl (ΔG‡rot 4.4 kcal/mol40).
Photophysical properties
The solution of 1a exhibited a green color, which is associated with an absorption transition range from 260 to 866 nm (Table 2 and Fig. 3a) and a broad band centered at approximately 627 nm (λabs). λabs of 1b, 1c, 1d, 2 and 3 were located at 745 nm, 650 nm, 699 nm, 652 nm, and 642 nm, respectively, indicating that the alkynyl-substituted compounds exhibited remarkable bathochromic effects. The contributions of the alkynyl moieties to the frontier orbitals are shown in Supplementary Fig. 12. The estimated optical HOMO-LUMO gaps (EgP) were as follows: 1b (1.40 eV) < 1d (1.48 eV) < 1c (1.56 eV) < 2 (1.60 eV) < 3 (1.66 eV) < 1a (1.68 eV).
Unlike the 13-(9-anthryl)-13H-DBF radical41 (ADBF radical in Fig. 3b, ε∼100 at 1220 nm), no such signal was observed in the long-wavelength region (1200–1600 nm) for the studied compounds in the steady-state absorption spectra even when the measurements were performed with highly concentrated samples. The photodynamics were probed using transient absorption (TA) spectroscopy with visible pump and near-infrared (NIR) probe pulses (Supplementary Fig. 13). 1b exclusively exhibited a significant excited-state absorption range from 1100–1500 nm (Fig. 3c). According to the characteristic absorption of the DBF radical41, NIR electronic transitions are associated with diradical formation and can be correlated to the first singlet excited state (S1) of 1b. The time trace of the TA spectra indicated that the S1 populations of 1b decay with a lifetime of approximately 90 fs (Fig. 3d), revealing the ultrafast time scales of the excited-state deactivation motions. A similar fluorescence decay time (ca. 90 fs) was also observed for 9,9’-BF42, indicating that the excited-state relaxation is dominated by rotational dynamics that are not strongly affected by the substituents or the π-system of the backbone.
Electrochemistry
The cyclic voltammogram of 1a in CH2Cl2 exhibited one irreversible oxidation signal (0.53 eV) and two reversible reduction waves (E½red = −1.06 and –1.36 eV, see Table 2 and Supplementary Fig. 14). Similar to 9,9’-BFs26,43, the addition of two electrons across the central C = C bond converted the studied compound into two (π-expanded) DBF anion units connected by a single bond. The driving forces in the reduction process should be steric strain relief and increased aromaticity to two [4n + 2] π-electron systems. Two-electron (quasi) reversible oxidations were observed in the voltammograms of 1b, 1c, and 1d. The 4-tolylethynyl substituents in 1b and 1d did act as π-extended electron-withdrawing groups to reduce both E½ox and E½red. However, the electron-donating effects of the methoxy groups in 1c decreased E½ox but increased E½red. Compound 3 with its highly distorted molecular halves demonstrated the highest first oxidation potential. Consequently, the electrochemical HOMO-LUMO gaps (EgE) of the studied compounds are ranked in the following order: 1b (1.26 eV) < 1d (1.38 eV) < 1c (1.46 eV) < 2 (1.49 eV) < 3 = 1a (1.59 eV), in line with that of EgP.
VT 1H NMR spectra
At room temperature, 1a exhibits well-resolved resonances in the 1H and 13C NMR spectra, and thermal treatments progressively broadened the spectral lines19 due to the small ΔEST value. Therefore, 1b and 2 must have even smaller ΔEST values. All signals for 1b (except 4-tolyl groups) as well as 6-H, 8-H, 10-H, and 13-H of 2 are highly broad in the 1H NMR spectra recorded at room temperature (Fig. 4a). The hydrogen atoms, which exhibited line broadening, are bound to the carbon atoms bearing remarkable spin density in the T1 state (Fig. 4b). Some broad signals also appeared in the 13C NMR spectra of 1b, 1d and 2.
VT 1H NMR experiments using unsymmetrical compounds 1d (183–303 K) and 2 (183–413 K) were performed (see Supplementary Information p. 43 and 45). Upon cooling, the signals exhibited progressive line sharpening without any significant decoalescence. The phenomenon is most likely due to the following three possibilities: (1) identical resonances of the syn- and anti-isomers, (2) the amount of energetically unstable isomer being too low to be detected, and (3) the C = C bond rotational rate at 183 K being faster than the timescale of 1H NMR spectroscopy. The first two options are unlikely, and the energy difference between the two isomers is less than 0.13 kcal/mol (see Supplementary Information p. 33), which results in an unstable isomer with a Boltzmann population greater than 40% at 183 K. In the VT 1H NMR spectra of 3, peaks with progressive line broadening were observed at temperatures higher than 303 K.
Magnetic properties
The temperature-dependent magnetic susceptibilities (χM) for powdered samples of 1a, 1b, 1c, 2, and 3 were obtained using a SQUID magnetometer. The χMT curves for all compounds exhibited decreasing trends when the temperature was decreased to 2 K, suggesting a singlet ground state (Supplementary Fig. 15). The value of ΔEST was estimated by fitting the temperature-dependent χMT data using the Bleaney-Bowers equation44. Satisfactory fits were achieved, and 1b exhibited the smallest ΔEST (3.65 kcal/mol) compared to the other compounds (4.32–5.68 kcal/mol, Table 2).
The ESR spectra of the powdered samples exhibited a featureless broad signal centered at g = 2.00 without ΔMs = ±2 transitions at room temperature (Supplementary Fig. 16)45. This spectral feature can be rationalized by the weak spin–spin dipole interaction between the two radicals46. The signal intensity of all studied compounds increases as the temperature increases from 300 to 400 K, and the most enhancement was observed for 1b. In contrast to other compounds, 1b exhibited the strongest intensity at room temperature, indicating the smallest ΔEST, the greatest spin delocalization over the molecule, including the 4-tolylethynyl substituents, and possibly a second-order contribution from dipolar interactions. A half-field signal attributed to the forbidden transition (ΔMS = ± 2) of the triplet state of 1b in the 2-methyltetrahydrofuran glass phase was observed at a temperature of 7 K, confirming the triplet state is slightly higher in energy (Fig. 4c). The ESR spectrum of 1b in the toluene glass state at 150 K displayed a hyperfine structure (Fig. 4d). A satisfactory fit to the experimental data yielded an isotropic signal at g = 2.0029 as well as a signal at g = 2.003 with AH = –13.9948 and –18.5058 MHz. The hyperfine coupling is attributed to the interaction of the radical with the 6-H/7-H atoms based on the spin density plot of 1b. Given the easily accessible triplet state, the data was also simulated using the two unpaired electron system including the anisotropic terms, yielding a satisfactory fit with g = 2.003 with D = 25 and E = 6.8 MHz. The hyperfine splitting due to radical/hydrogen or radical/radical interactions (or both together) cannot be completely confirmed as the dipolar and nuclear hyperfine terms have a similar order of magnitude. The ESR spectrum of the solution sample of 1b displays the characteristics of a monoradical doublet state ( >150 K, Fig. 4e). Similar to nitroxide11,47 and dithiazole diradicals48,49, 1b also possesses strong intramolecular magnetic exchange coupling (–2 J) that is much greater than the hyperfine parameter (|–2 J | ≫ |A | ), creating the monoradical-like hyperfine feature. A broad signal is dominant due to the fast molecular tumbling effect as the temperature increase to more than 150 K. The observed hyperfine structure of 1b was obscured in the solid-state spectra, presumably due to the broadening caused by intermolecular dipolar coupling.
In summary, the syntheses, X-ray crystallographic structures, and properties of several highly twisted alkenes were systematically investigated. The target molecules were prepared from the corresponding benzofluorene derivative through titanium-mediated dimerization and subsequent oxidative dehydrogenation. The properties of the studied compounds are strongly associated with the substituents, the π system, and the molecular geometry. Compound 1b possessed the smallest ΔH‡rot (2.35 kcal/mol), ΔEST (3.65 kcal/mol), and EgE (1.26 eV) values, which were associated with the stabilization effect of the 4-tolylethynyl substituents. Such a low ΔH‡rot value indicates that the rotation of the C = C bond could be as facile as an aryl-aryl bond in a simple biphenyl. The molecular geometry of 1b has three essential structural features, namely a highly twisted and elongated C = C bond (θ1 = 58°, d = 1.43 Å), an extended π-system, and a quasi-planar molecular half-fragment (θ2 < 5°). The final is very close to those in the TSrot and the T1 state (θ2 = 0°) and important to buttress the highly twisted C = C bond. The π-extended substituent 4-tolylethynyl group (in 1b) is superior to the π-expanded backbone (in 2 and 3) not only in reducing the Eg height but also for stabilizing TSrot and T1. Exclusively, 1b exhibits significant excited-state absorption in the TA spectrum, denoting the formation of the stabilized S1 state with a diradical character. With this successful synthetic approach and essential molecular design information, applications of functionalized π-extended twisted alkenes as organic materials and molecular machines are currently being explored. Despite the progress made in increasing the rotational rates of these alkenes, constructing a molecular motor with unidirectional rotation remains a significant challenge5.
Methods
Synthesis
General procedure for synthesis of compounds 7a–d, 8, and 9
To a solution of a fluorene derivative (1.00 mmol) in anhydrous THF (10 mL) at −78 °C, a solution of nBuLi (1.10 mmol) was dropwise added. After being stirred at the same temperature for 1 h, the solution was treated with a solution of TiCl4 (1.00 mmol) in toluene. The reaction mixture was slowly warmed to room temperature and stirred overnight. The product was collected by filtration, rinsed with water (20 mL) and dried in vacuo. In some cases, additional products can be obtained from the filtrate by chromatography on silica gel. For details, see Supplementary Information.
Procedure for synthesis of highly twisted alkenes 1a–d, 2, and 3
Compounds 1a–d, 2, and 3 were prepared from 7a–7d, 8 and 9, respectively, by the tBuOK-mediated oxidative dehydrogenation. The reaction conditions were substrate dependent. For details, see Supplementary Information.
Characterization
NMR spectra were recorded on Brucker 400 MHz (1H, 400 MHz), 500 MHz (1H, 500 MHz; 13C, 125 MHz), and 700 MHz (1H, 700 MHz; 13C, 175 MHz) spectrometers. Chemical shifts are reported in δ (ppm) relative to the solvent peak: chloroform-d (CDCl3: 1H, 7.26 ppm; 13C, 77.00 ppm), dichloromethane-d2 (CD2Cl2: 1H, 5.32 ppm; 13C, 53.80 ppm) and 1,1,2,2-tetrachloroethane-d2 (C2D2Cl4: 1H, 6.00 ppm; 13C, 73.78 ppm). High-resolution mass spectra (HRMS) were obtained on JEOL JMS-700, JEOL AccuTOF GCx-plus or Bruker New ultrafleXtreme Mass Spectrometers. Melting points were determined with a Büchi melting point apparatus B545 and are uncorrected.
X-Ray crystallography
Crystals of 1a, 1b and 1c were obtained by slow diffusion of methanol in the dichloromethane solutions at room temperature. Crystals of 3 were grown from dichloromethane by slow evaporation of the solvent at room temperature. Single-crystal X-ray diffraction was performed on a Bruker D8 Venture Single-Crystal X-Ray Diffractometer or Rigaku XtaLAB Synergy DW, and the data were collected and processed by using a PHOTON III detector and a HyPix-Arc 150° curved hybrid photon counting X-ray detector, respectively.
DFT calculations
All of the DFT calculations were calculated using the B3LYP functional50 with the addition of D3 dispersion correction51 unless stated otherwise. The double-z quality 6-31 G** basis set52 was chosen for geometry optimization and thermodynamic correction (ZPE, Hvib, Htrans, Hrot), while the triple-z quality 6-311 + + G** basis set was used for obtaining more accurate electronic energies (Eelec). The reported energies are enthalpies, which were calculated based on the following equation:
\(H={E}_{{{{{{\rm{elec}}}}}}}+{{{{{\rm{ZPE}}}}}}+({H}_{{{{{{\rm{vib}}}}}}}+{H}_{{{{{{\rm{trans}}}}}}}+{H}_{{{{{{\rm{rot}}}}}}}+{{{{{\rm{RT}}}}}})\)
Cyclic voltammetry
The electrochemical measurements were carried out with a CH Instruments 621E potentiostat at room temperature, using a three-electrode cell under a nitrogen atmosphere. Cyclic voltammograms (CV) were recorded with a glassy carbon working electrode, a Pt counter electrode and a Ag/AgNO3 (0.1 M AgNO3 and 0.1 M N(nBu)4ClO4 in acetonitrile) reference electrode in an electrolyte solution of 0.1 M TBAPF6 (tetrabutylammonium hexafluorophosphate) in CH2Cl2 with a scan rate of 0.1 V/s. The potential was externally calibrated against the ferrocene/ferrocenium couple.
Photophysical Properties
Steady-state absorption spectra were measured by Perkin Elmer (Lambda 950) spectrophotometer. The detailed setups of the light source and transient absorption spectroscopy are described in Supplementary Information.
Magnetic properties
The temperature-dependent molar magnetic susceptibility of crystalline solid samples was measured on a Quantum Design SQUID-VSM magnetometer with an applied field of 5000 G or 2000 G. The magnetic susceptibility data were corrected for the diamagnetic contribution of the capsule and the sample holder. Molar susceptibility data were corrected for diamagnetic contribution of Pascal’s constants53, The ESR measurements were obtained with a Bruker EMX-10/12 and EPR-plus X-band (9.4 GHz) digital EPR spectrometer with Bruker N2-temperature controller. Spectral analysis and simulations were performed using the EasySpin program.
Data availability
All experimental procedures, characterization data and NMR spectra are available within the article and the Supplementary Information. The X-ray crystallographic data for structures reported in this study have been deposited at the Cambridge Crystallographic Data Centre (CCDC), under deposition numbers 2116430 (1a), 2204920 (1b), 2204921 (1c), and 2116431 (3). These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif.”. Supplementary Data 1 (the Cartesian coordinates of optimized structures) are provided with this paper.
References
Saltiel, J. & Charlton, J. L. Cis-trans isomerization of olefins in Rearrangements in Ground and Excited States (ed. de Mayo, P.), Vol. 3, 25–89 (Academic Press, New York, 1980).
Doering, W. V. E. et al. Rotationsbarrieren gespannter Olefine. Chem. Ber. 122, 1263–1275 (1989).
Qi, F. et al. Photodissociation of ethylene sulfide at 193 nm: a photofragment translational spectroscopy study with VUV synchrotron radiation and ab initio calculations. J. Am. Chem. Soc. 123, 148–161 (2001).
Dugave, C. & Demange, L. Cis−trans isomerization of organic molecules and biomolecules: Implications and applications. Chem. Rev. 103, 2475–2532 (2003).
Pooler, D. R. S., Lubbe, A. S., Crespi, S. & Feringa, B. L. Designing light-driven rotary molecular motors. Chem. Sci. 12, 14964–14986 (2021).
Sandström, J. Static and dynamic stereochemistry of push-pull and strained ethylenes. Top. Stereochem. 14, 83–181 (1983).
Shvo, Y. & Shanan-Atidi, H. Internal rotation in olefins. I. Kinetic investigation by nuclear magnetic resonance. J. Am. Chem. Soc. 91, 6683–6689 (1969).
Tschitschibabin, A. E. Über einige phenylierte derivate des p,p-Ditolyls. Ber. Dtsch. Chem. Ges. 40, 1810–1819 (1907).
Montgomery, L. K., Huffman, J. C., Jurczak, E. A. & Grendze, M. P. The molecular structures of Thiele’s and Chichibabin’s hydrocarbons. J. Am. Chem. Soc. 108, 6004–6011 (1986).
Diradicaloids (ed. Wu, J.), (Jenny Stanford Publishing, 2022).
Ravat, P. & Baumgarten, M. “Tschitschibabin type biradicals”: benzenoid or quinoid? Phys. Chem. Chem. Phys. 17, 983–991 (2015).
Ni, Y. et al. A Chichibabin’s hydrocarbon-based molecular cage: The impact of structural rigidity on dynamics, stability, and electronic properties. J. Am. Chem. Soc. 142, 12730–12742 (2020).
Zeng, Z. et al. Stable tetrabenzo-Chichibabin’s hydrocarbons: Tunable ground state and unusual transition between their closed-shell and open-shell resonance forms. J. Am. Chem. Soc. 134, 14513–14525 (2012).
Nishiuchi, T., Aibara, S., Sato, H. & Kubo, T. Synthesis of π‐extended Thiele’s and Chichibabin’s hydrocarbons and effect of the π‐congestion on conformations and electronic states. J. Am. Chem. Soc. 144, 7479–7488 (2022).
Beck, A., Gompper, R., Polborn, K. & Wagner, H. U. Bi[1,3-bis(dicyanomethylene)indan-2-ylidene] — An ethylene derivative with extremely pronounced, twisting of the C-C bond. Angew. Chem. Int. Ed. 32, 1352–1354 (1993).
Molins, E., Miravitlles, C., Espinosa, E. & Ballester, M. 1,1’,3,3’,6,6’,8,8’-Octachloro-9,9’-bifluorenylidene and perchloro-9,9’-bifluorenylidene, two exceedingly twisted ethylenes. J. Org. Chem. 67, 7175–7178 (2002).
Beck, A. H. Sterisch Gehinderte Doppelbindungssysteme, Dissertation, Ludwig-Maximilians-Universität München, Germany, 1993. (X-ray crystallographic data for 1a CCDC-164108).
Ranzen, V. & Joschek, H.-I. Zum Radikalcharakter des Bis-Dibenzo[a.i]Fluorenylidens. Justus Liebigs Ann. Chem. 648, 63–68 (1961).
Wentrup, C., Regimbald‐Krnel, M. J., Müller, D. & Comba, P. A thermally populated, perpendicularly twisted alkene triplet diradical. Angew. Chem. Int. Ed. 55, 14600–14605 (2016).
Hamamoto, Y., Hirao, Y. & Kubo, T. Biradicaloid behavior of a twisted double bond. J. Phys. Chem. Lett. 12, 4729–4734 (2021).
Prajapati, B. et al. Tetrafluorenofulvalene: A sterically frustrated open-shell alkene. Nat. Chem. accepted. (https://doi.org/10.21203/rs.3.rs-2587889/v1).
Lenoir, D., Smith, P. J. & Liebman, J. F. Distorted alkenes. in Strained Hydrocarbons; Beyond the van’t Hoff and Le Bel Hypothesis (ed. Dodziuk, H.), 103–145 (Wiley-VCH, Weinheim, 2009).
Biedermann, P. U. & Agranat, I. Stereochemistry of bistricyclic aromatic enes and related polycyclic systems. Top. Curr. Chem. 350, 177–278 (2014).
Kanawati, B., Genest, A., Schmitt-Kopplin, P. & Lenoir, D. Bis-dibenzo[a.i]fluorenylidene, does it exist as stable 1,2-diradical? J. Mol. Model. 18, 5089–5095 (2012).
Wu, J. I.-C. & Schleyer, von Ragué P. Hyperconjugation in hydrocarbons: Not just a “mild sort of conjugation”. Pure Appl. Chem. 85, 921–940 (2013).
Brunetti, F. G. et al. Strain and Hückel aromaticity: driving forces for a promising new generation of electron acceptors in organic electronics. Angew. Chem. Int. Ed. 49, 532–536 (2010).
Gong, X. et al. Bulk heterojunction solar cells with large open-circuit voltage: electron transfer with small donor-acceptor energy offset. Adv. Mater. 23, 2272–2277 (2011).
Kawata, S. et al. Controlling the excited-state energy levels of 9,9′-bifluorenylidene derivatives by twisting their structure to attaining singlet fission character in organic photovoltaics. J. Mater. Chem. C 5, 4909–4914 (2017).
Yamada, K. et al. Fulvalene derivatives containing a tetrabenzofluorene unit: new nonplanar fulvalenes with high electron affinity. Synlett 27, 2085–2090 (2016).
Magidson, O. I. Schliessung des Fluoren-Ringes in der Di-α-naphthyl-methan-Reihe. Ber. Dtsch. Chem. Ges. 58B, 433–442 (1925).
Régimbald-Krnel, M. & Wentrup, C. On the di-1-naphthylcarbene−dibenzofluorene rearrangement and the ethylenization of diarylcarbinols. J. Org. Chem. 63, 8417–8423 (1998).
Schröder, K. et al. Tetrabenzo[a,c,g,i]fluorenyllithium and η5-tetrabenzo[a,c,g,i]fluorenyl-titanium complexes. Organometallics 25, 3824–3836 (2006).
Barham, J. P. et al. KOtBu: A privileged reagent for electron transfer reactions? J. Am. Chem. Soc. 138, 7402–7410 (2016).
Escher, A., Rutsch, W. & Neuenschwander, M. Synthese von Pentafulvalen durch oxidative Kupplung von Cyclopentadienid mittels Kupfer(II)-chlorid. Helv. Chim. Acta 69, 1644–1654 (1986).
Øpstad, C. L., Melø, T.-B., Sliwka, H.-R. & Partali, V. Formation of DMSO and DMF radicals with minute amounts of base. Tetrahedron 65, 7616–7619 (2009).
Frey, O. N. et al. Remarkable stability of tetrabenzo[a,c,g,i]fluorenyl ammonium salts in water: syntheses, reactions, and crystal structures. Dalton Trans. 45, 1085–1092 (2016).
Kubo, T. et al. Synthesis, Intermolecular interaction, and semiconductive behavior of a delocalized singlet biradical hydrocarbon. Angew. Chem. Int. Ed. 44, 6564–6568 (2005).
Frisch, M. et al. Gaussian 09, Revision A.02, (Gaussian, Inc, Wallingford CT, 2016).
Xu, X. et al. 6,6′-Biindeno[1,2‑b]anthracene: An open-shell biaryl with high diradical character. J. Am. Chem. Soc. 145, 3891–3896 (2023).
Mazzanti, A. et al. The torsional barriers of 2-hydroxy- and 2-fluorobiphenyl: Small but measurable. Chem. Eur. J. 16, 9186–9192 (2010).
Tian, Y. et al. Design and synthesis of new stable fluorenyl-based radicals. J. Am. Chem. Soc. 136, 12784–12793 (2014).
Conyard, J. et al. Ultrafast excited state dynamics in 9,9′-bifluorenylidene. J. Phys. Chem. A 118, 5961–5968 (2014).
Cohen, Y., Klein, J. & Rabinovitz, M. Stable polycyclic anions: dianions from overcrowded ethylenes. J. Chem. Soc. Chem. Commun. 1071–1073 (1986).
Bleaney, B. & Bowers, K. D. Anomalous paramagnetism of copper acetate. Proc. R. Soc. London Ser. A 214, 451–465 (1952).
Liu, J. et al. Open-shell nonbenzenoid nanographenes containing two pairs of pentagonal and heptagonal rings. J. Am. Chem. Soc. 141, 12011–12020 (2019).
Eaton, S. S., More, K. M., Sawant, B. M. & Eaton, G. R. J. Use of the ESR half-field transition to determine the interspin distance and the orientation of the interspin vector in systems with two unpaired electrons. J. Am. Chem. Soc. 105, 6560–6567 (1983).
Dupeyre, R. M., Rassat, A. & Ronzaud, J. Nitroxides. LII. Synthesis and electron spin resonance studies of N,N’-dioxy-2,6-diazaadamantane, a symmetrical ground state triplet. J. Am. Chem. Soc. 96, 6559–6568 (1974).
Barclay, T. M. et al. The heterocyclic diradical benzo-1,2:4,5-bis(1,3,2-dithiazolyl). electronic, molecular and solid state structure. J. Am. Chem. Soc. 119, 2633–2641 (1997).
Dormann, E. et al. Benzobisdithiazole (BBDT): An electron spin resonance study. J. Am. Chem. Soc. 109, 2594–2599 (1987).
Lee, C., Yang, W. & Parr, R. G. Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. Phys. Rev. B 37, 785 (1988).
Grimme, S., Antony, J., Ehrlich, S. & Krieg, H. A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. J. Chem. Phys. 132, 154104 (2010).
Francl, M. M. et al. Self‐consistent molecular orbital methods. A polarization‐type basis set for second‐row elements. XXIII. J. Chem. Phys. 77, 3654 (1982).
Bain, G. A. & Berry, J. F. Diamagnetic corrections and pascal’s constants. J. Chem. Educ. 85, 532–536 (2008).
Acknowledgements
This work was financially supported by the National Science and Technology Council of Taiwan (MOST-110-2113-M-006-012-MY3, Y.T.W.; MOST-110-2639-M-002-001-ASP, P.T.C. and MOST-111-2113-M-006-010-MY3, M.J.C.) and Academia Sinica (AS-iMATE-111-21, M.H.C.). Instrumentation Centers at the National Tsing Hua University and the National Cheng Kung University are acknowledged for the X-ray structure analyses.
Author information
Authors and Affiliations
Contributions
Y.T.W. conceived the idea and designed the experiments. H.W.K. undertook the synthesis and analysis of all compounds, as well as the measurement of photoabsorption and electrochemical properties. M.H.C. directed investigations of magnetic properties. Y.C.L. conducted the ESR and SQUID measurements. M.J.C. provided guidance for the computational studies, while C.T.H. and W.K.S. executed the DFT calculations. P.T.C. and S.D.Y. supervised photodynamic investigations. B.H.C., C.H.L. and Y.C.W. measured the TA spectra and analyzed data. M.H.C, P.T.C. and Y.T.W. co-wrote the manuscript. All authors discussed the results and commented on the manuscript.
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Peer review
Peer review information
Nature Communications thanks the anonymous reviewers for their contribution to the peer review of this work. A peer review file is available.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Kang, HW., Liu, YC., Shao, WK. et al. Synthesis, structural analysis, and properties of highly twisted alkenes 13,13’-bis(dibenzo[a,i]fluorenylidene) and its derivatives. Nat Commun 14, 5248 (2023). https://doi.org/10.1038/s41467-023-40990-8
Received:
Accepted:
Published:
DOI: https://doi.org/10.1038/s41467-023-40990-8
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.