Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines

Abstract

Chiral α-aryl glycines play a key role in the preparation of some bioactive products, however, their catalytic asymmetric synthesis is far from being satisfactory. Herein, we report an efficient nickel-catalyzed asymmetric hydrogenation of N-aryl imino esters, affording chiral α-aryl glycines in high yields and enantioselectivities (up to 98% ee). The hydrogenation can be conducted on a gram scale with a substrate/catalyst ratio of up to 2000. The obtained chiral N-p-methoxyphenyl α-aryl glycine derivatives are not only directly useful chiral secondary amino acid esters but can also be easily deprotected by treatment with cerium ammonium nitrate for further transformations to several widely used molecules including drug intermediates and chiral ligands. Formation of a chiral Ni-H species in hydrogenation is detected by 1H NMR. Computational results indicate that the stereo selection is determined during the approach of the substrate to the catalyst.

Introduction

Chiral α-amino acids have found broad applications in the fields of pharmaceutical, biological, and synthetic chemistry1,2. Therefore, the synthesis of these compounds is of considerable importance. In the past decades, the synthesis of chiral α-alkyl amino acids, mainly via the asymmetric hydrogenation of the corresponding α-dehydroamino acid derivatives, has been widely investigated affording excellent results3,4,5,6,7. A prominent example is the industrial preparation of L-DOPA developed by Knowles, which has received high praise and won the Nobel Prize in Chemistry in 20018. As another category of α-amino acids, chiral α-aryl glycines play a key role in synthetic drugs as well as bioactive natural products (Fig. 1a)9,10,11,12.

Fig. 1: Asymmetric hydrogenation of N-aryl imino esters for the synthesis of chiral α-aryl glycines.
figure1

a Representative chiral products bearing chiral α-aryl glycine skeletons. b Previous work about asymmetric hydrogenation of N-aryl imino esters. c Previous work about Ni-catalyzed asymmetric hydrogenation of activated imines. d This work: Ni-catalyzed asymmetric hydrogenation of imino esters.

In order to obtain these building blocks, many methodologies have been developed13,14,15,16,17. Among various approaches, the transition-metal-catalyzed asymmetric hydrogenation of α-aryl imino esters provides a promising route in terms of both efficiency and practicality. However, due to the coexistence of Z/E isomers and the intrinsically low activity of the substrates, studies in this area are still far from satisfactory18,19,20,21,22,23,24,25,26,27,28,29,30. Although several strategies have been developed to overcome these drawbacks, including introducing activated groups like N-sulfonyl imino esters or using cyclic imino esters, the corresponding products either contain groups which cannot be easily removed or are limited to cyclic derivatives18,19,20,21,22,23,24,25,26,27. As an alternative, N-p-methoxyphenyl (PMP) substrates have the advantages of possessing a readily removable PMP group and greater substrate diversity. Some asymmetric hydrogenations of N-PMP α-aryl imino esters based on noble transition-metal catalysts of Pd, Rh, and Ir have been reported with good results (S/C up to 1000, Fig. 1b)28,29,30.

In view of current interest in the development of earth-abundant metal catalysts in asymmetric hydrogenation31,32,33,34,35,36,37,38,39,40,41, which are inexpensive and environmentally friendly, the use of nickel has drawn increasing attention24,31,32,33,34,35,36,37,38,39,40,41. Although Ni-catalyzed asymmetric reduction has seen rapid development, the asymmetric hydrogenation of imines is still in its infancy24,42,43,44. To date, only a few Ni-catalyzed asymmetric hydrogenations of imines have been reported by Zhang24,43,44 and our group42, and the imines substrates are all activated by N-sulfonyl groups (Fig. 1c). The electronic-withdrawing sulfonyl substituents at the nitrogen atom can increase the electrophilicity of the imine carbon, which is more vulnerable to hydride attack. To the best of our knowledge, there is still no Ni-catalyzed asymmetric hydrogenation of unactivated N-aryl imines. Continuing our pursuit of earth-abundant metal-catalyzed asymmetric hydrogenation38,39,42, herein we disclose an efficient Ni-catalyzed asymmetric hydrogenation of N-PMP imino esters for the synthesis of useful chiral α-aryl glycines (Fig. 1d).

Results

Investigation of reaction conditions

Initially, our investigations were performed using (Z/E)-methyl-2-((4-methoxyphenyl)imino)-2-phenylacetate (1a) as a model substrate with 1 mol% catalyst under 30 bar H2 at 50 °C for 24 h. As listed in Table 1, a variety of chiral diphosphine ligands (entries 1–7) and commonly used solvents (entries 8–14) were explored.

Table 1 Reaction optimizationa.

When (S)-BINAP was used, only a trace amount of product was obtained (entry 1). By replacing (S)-BINAP with the electron-rich ligand (S)-SegPhos, the conversion of 1a was improved from 7% to 50% (entry 2). To our delight, introducing a more electron-rich alkyl phosphine to the ligand could dramatically increase the reaction activity (entries 3-7), and full conversion with the best enantioselectivity (99% conv, 96% ee) was obtained by using the chiral dialkyl phosphine ligand (R,R)-BenzP* (entry 7). In solvent screening experiments, 2,2,2-trifluoroethanol (TFE) provided the best result for this reaction. Other protic solvents, such as MeOH, EtOH and (CF3)2CHOH, were viable but gave the desired product with low ee values (entries 8-10), whereas the use of aprotic solvents, such as toluene, CH2Cl2, EtOAc, and THF resulted in no or little reactivity (entries 11-14).

Scope of asymmetric catalysis of N-PMP α-aryl imino esters

With the optimized reaction conditions in hand (Table 1, entry 7), we next investigated the substrate scope of this asymmetric hydrogenation (Table 2). Substrates with both electron-donating (Me, MeO, etc.) and electron-withdrawing (F, Cl, Br, etc.) groups could be hydrogenated to the corresponding products with good to high yields and excellent ees (2b-2t, 90–98% ee) regardless of the positions on the aryl moieties. To our delight, the 3-NO2 substituted N-aryl imino ester 1k was also amenable to the reaction conditions (83% yield, 90% ee) with no reduction of the NO2 group being observed, even at a higher temperature. Disubstituted and naphthyl substrates were also evaluated in the catalytic reactions, affording excellent results (2u-2ab, 92–98% ee). Altering the ester groups showed no obvious influence on the reactivity and enantioselectivity (2ac-2ae). Changing the esters to amide groups also afforded good results with only slightly lower yields of the corresponding products (2af and 2ag). The reaction was also applicable to heteroaryl substituents (1ah and 1ai) affording the desired products in 90%/23% yield and 73%/39% ee, respectively. Excellent results were also obtained when replacing the PMP with other aryl groups (2aj-2am, 94–98% ee). It should be noted that methyl substituted substrate 1am was smoothly hydrogenated to product 2am with 94% yield and 98% ee, which is a key intermediate for the synthesis of the chiral fungicide (R)-metalaxyl45. The absolute configuration of product 2a was assigned to be R by X-ray crystallographic analysis.

Table 2 Substrate scopea.

Synthetic utility of chiral α-aryl glycine products

To demonstrate the synthetic utility of this method, a gram scale experiment with a high substrate/catalyst ratio (S/C = 2000) was carried out (Fig. 2a). As a result, 1a was hydrogenated to produce 2a with 92% yield and 93% ee. It should be noted that a high Ni/ligand ratio was vital for the reaction efficiency (see SI for details). Next, several transformations of the chiral α-aryl glycine derivatives were conducted. The PMP group of product 2a could be smoothly removed by the use of cerium ammonium nitrate (CAN) to give the deprotected product 3 in high yield and without an obvious loss of enantioselectivity (Fig. 2b). The chiral primary amine 3 is an intermediate for the synthesis of the marketed drug Ampicillin (Fig. 2b)46. The hydrolysis of 3 gave the chiral α-aryl glycine hydrochloride 4, which could be further transformed to chiral compound 5, an intermediate for the synthesis of the commercial drug Elobixibat hydrate (Fig. 2c)47. The compound 3 was also reduced with NaBH4 to afford the corresponding amino alcohol 6, which was further transformed to chiral compound 8 via intermediate 7 (Fig. 2d). Chiral compound 8 has been widely used as a ligand for numerous asymmetric catalytic reactions48. Chiral (S)-6 derived from (S)-3 could be also transformed to 9, which is an intermediate for the synthesis of the HCV NS5B polymerase inhibitor (Fig. 2e)49.

Fig. 2: Practical applications.
figure2

a A gram scale experiment. b The removal of PMP. c The synthesis of elobixibat hydrate intermediate. d The synthesis of ligand 8. e The synthesis of HCV NS5B polymerase inhibitor intermediate.

The studies of coordination and Ni-H species

Active chiral metal hydride species are the crucial intermediates in the transition-metal-catalyzed asymmetric hydrogenation process, but they are very difficult to detect and isolate due to their high-activities and generation in only trace amounts50. Thus, the active chiral nickel hydride species has remained undetected, albeit several chiral diphosphine ligand nickel complexes have been well studies. In this study, at first, based on our previous studies of Ni catalysts39,42, the coordination behaviors of Ni salt and the ligand BenzP* were studied. Unlike previous investigations39,42, (R,R)-BenzP* (L) coordinates with Ni(OAc)2·4H2O (M) to form a dual-ligand coordinated complex 10 with different L/M ratios in CF3CD2OD, with none of the mono-ligand coordinated complex 11 being detected by 1H NMR and HRMS, probably because it exists in trace amounts in an equilibrium with the dominating complex 10 (Fig. 3a). Afterwards, a sample analyzed upon hydrogenation of the solution containing a 1:1 ratio of L/M exhibited a weak hydride signal at δ = −13.52 ppm (t, 2JP-H = 14.8 Hz) (Fig. 3b). The triplet structure of this signal is evidence of its coupling with two equivalent cis-phosphorus atoms that strongly supports the presence of the structure 12. Similar species were previously detected for the analogous Pd complex50, and it is commonly accepted that these species are real catalysts in Pd-catalyzed hydrogenations. Hence, our experimental observation supports previous studies, in that a nickel hydride complex most likely acts as the catalyst39,42.

Fig. 3: The experimental studies of coordination and Ni-H species.
figure3

a Formation of the catalyst 12. b 1H NMR Spectrum of Ni−H.

Z/E isomers interconversion and deuterium labeling experiments

The 1H NMR spectrum of a crystal of (Z)-1a dissolved in the solvent showed a mixture of Z/E isomers, indicating that there is rapid interconversion between the two isomers (Supplementary Fig. 5). Furthermore, complete deuteration occurred at the prochiral carbon atom in a deuterium labeling experiment using D2 (Supplementary Fig. 6).

Mechanistic considerations

Based on the above experimental results, we have computed a catalytic cycle for the reaction under study considering four competing reaction pathways (R- and S-pathways for (Z)-1a and (E)-1a, e.g. Fig. 4a). On approach of (Z)-1a or (E)-1a to the catalyst 12, we have located four diastereomers of the chelate complex 13. Further approach along the same coordinate results in the hydride transfer producing intermediate 14. Coordination of H2 to 14 forms complex 15, which undergoes subsequent sigma-bond metathesis to give complex 16. Finally, 2a is released to regenerate the Ni-H species necessary for the next catalytic turnover.

Fig. 4: Computed mechanism of catalytic cycle and important stabilizing interactions (Angstrom).
figure4

a Computed mechanism of catalytic cycle. b Optimized structures of TS1(R). c Optimized structures of TS1(S).

Enantioselectivity is generated during hydride transfer via TS1. Among four computed transition states, the two most stable originate from (E)-1a; TS1(R) is 1.8 kcal/mol more stable than TS1(S) (see SI for details). The main structural difference leading to the notable alteration in their energies is the interaction of the carboxymethyl substituent with the hydride being transferred from Ni to carbon. This is illustrated in Fig. 4b: in the S transition state only one quite long HO contact of this type can be found, whereas in the R transition state the carboxymethyl group is completely involved in stabilization of the TS1(R) transition state via appropriately distanced intramolecular interactions (the distance C(carbonyl)-H(hydride) is 2.03 Å). This is further illustrated in Fig. 4c.

Usually, migratory insertion of a metal hydride proceeds via gradual elongation of the M–H bond supported by gradual shortening of the H–C distance and formation of an M–C (or M–N) bond. These processes are characterized by high absolute values of the imaginary vibrations in the corresponding transition states.

In all four computed reaction pathways, the hydride insertion proceeds differently: the very low barrier (1-2 kcal/mol) or even barrierless hydride transfer takes place after the formation of a configuration with coplanar orientation of Ni-C and Ni-H bonds that requires initial elongation of the C-N bond resulting in the appearance of the activation barrier (Fig. 5, see SI for details)51. Hence, stereoselection actually occurs at the stage of achieving a proper mode of the substrate coordination for the subsequent hydride transfer52, which parallels that of Rh-catalyzed asymmetric hydrogenation53,54.

Fig. 5: Intrinsic mechanism of the hydride transfer.
figure5

The configuration with coplanar orientation of Ni–C and Ni–H bonds.

Experimentally observed enantioselection (96% ee) attests to a higher energy difference (about 2.3 kcal/mol). Our computations suggest that the alternative pathways, avoiding formation of chelating complexes 13, can be more stereoselective, and their interference may improve the optical yields.

To gain further insight into the asymmetric pathways, detailed computational studies of the approach of the substrate to the catalyst were conducted. From Fig. 6, it is clear that stereo differentiation could be effectively achieved at this stage. Thus, both pathways leading to the experimentally observed R-product are continuously lower in energy than both alternative pathways starting from the separation distance of 4 Å. The energy gap between the approaching curves for ES and ZR is continuously maintained at approximately 6.9 kcal/mol which is enough to secure perfect enantioselection. Of course, thermodynamics should favor the formation of the complexes 13, but the interference of the pathways shown in Fig. 6 cannot be excluded.

Fig. 6: Energy scans simulating the approach of 1a to the catalytic hydride 12.
figure6

ZS, ER, ZR, ES: the approach of (Z)-1a or (E)-1a to the catalyst to form the products (S)-2a or (R)-2a, respectively.

It should be noted that the steep drop in the molecular relative energy starting at each of the four pathways at approximately 2.4 Å corresponds to the building of Ni–C bonding, since at that stage the length of the Ni–H bond is not yet increasing. Really, barrierless migratory insertion begins at approximately 2.1 Å in each case, i.e. in the area when the difference between the relative energies of the four pathways can be neglected (Fig. 6). Hence, the stereodiscrimination in this case is also achieved on the stage of the approach of the substrate to the catalyst.

Discussion

In summary, we have developed an efficient Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters to synthesize chiral α-aryl glycines in high yields and with excellent enantioselectivities (up to 98% ee). The reaction proceeded smoothly on a gram scale at a low catalyst loading (S/C up to 2000). The obtained products were directly useful chiral secondary amino acid ester or further applied to the synthesis of several widely used molecules including drug intermediates and chiral ligand. A chiral active Ni–H species has been discovered first using NMR spectroscopy. Computational results indicate that the stereo selection is determined during the approach of the substrate to the catalyst.

Methods

General procedure for asymmetric hydrogenation of N-aryl imino esters/amides

To a hydrogenation tube, Ni(OAc)2·4H2O (0.75 mg, 0.003 mmol), (R,R)-BenzP* (0.85 mg, 0.003 mmol) and the substrate (S/C = 100) were added, and then the mixture was transferred to a nitrogen-filled glovebox. The degassed and anhydrous trifluoroethanol (TFE, 1.0 mL) was added. The reaction was performed with H2 (30 bar) at 50 °C for 24 h. After carefully releasing hydrogen gas, the pure product is obtained by column chromatography (PE/EtOAc). The enantiomeric excess was determined by chiral HPLC.

Data availability

The authors declare that the data supporting the findings of this study are available within the article and its Supplementary Information file. For the experimental procedures, data of NMR and HPLC analysis and Cartesian coordinates of the optimized structures, see Supplementary Methods in Supplementary Information file. The X-ray crystallographic coordinates for structures reported in this article have been deposited at the Cambridge Crystallographic Data Centre (Z-1a: CCDC 2011640 [https://www.ccdc.cam.ac.uk/structures/Search?access=referee&ccdc=2011640&Author=Liu+Dan], R-2a: CCDC 2011648 [https://www.ccdc.cam.ac.uk/structures/Search?access=referee&ccdc=2011648&Author=Dan+Liu]). These data could be obtained free of charge from The Cambridge Crystallographic Data Centre (https://www.ccdc.cam.ac.uk/structures/).

References

  1. 1.

    Hughes, A. B. Amino Acids, Peptides, and Proteins in Organic Chemistry (Wiley-VCH, Weinheim, 2009).

  2. 2.

    Lundblad, R. L. & Macdonald, F. Handbook of Biochemistry and Molecular Biology (CRC Press, Cleveland, 2018).

  3. 3.

    Xie, J.-H., Zhu, S.-F. & Zhou, Q.-L. Transition metal-catalyzed enantioselective hydrogenation of enamines and imines. Chem. Rev. 111, 1713–1760 (2011).

    CAS  PubMed  Article  Google Scholar 

  4. 4.

    Wang, D.-S., Chen, Q.-A., Lu, S.-M. & Zhou, Y.-G. Asymmetric hydrogenation of heteroarenes and arenes. Chem. Rev. 112, 2557–2590 (2012).

    CAS  PubMed  Article  Google Scholar 

  5. 5.

    Chen, Q.-A., Ye, Z.-S., Duan, Y. & Zhou, Y.-G. Homogeneous palladium-catalyzed asymmetric hydrogenation. Chem. Soc. Rev. 42, 497–511 (2013).

    CAS  PubMed  Article  Google Scholar 

  6. 6.

    Wang, Y., Zhang, Z. & Zhang, W. Asymmetric hydrogenation of cyclic dehydroamino acids and their derivatives. Chin. J. Org. Chem. 35, 528–538 (2015).

    CAS  Article  Google Scholar 

  7. 7.

    Zhang, Z., Butt, N. A. & Zhang, W. Asymmetric hydrogenation of nonaromatic cyclic substrates. Chem. Rev. 116, 14769–14827 (2016).

    CAS  PubMed  Article  Google Scholar 

  8. 8.

    Knowles, W. S. Asymmetric hydrogenations (Nobel Lecture). Angew. Chem. Int. Ed. 41, 1998–2007 (2002).

    CAS  Article  Google Scholar 

  9. 9.

    Wegman, M. A., Janssen, M. H. A., van Rantwijk, F. & Sheldon, R. A. Towards biocatalytic synthesis of β-lactam antibiotics. Adv. Synth. Catal. 343, 559–576 (2001).

    CAS  Article  Google Scholar 

  10. 10.

    Mast, Y. et al. Characterization of the ‘pristinamycin supercluster’ of streptomyces pristinaespirali. Microb. Biotechnol. 4, 192–206 (2011).

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  11. 11.

    Wong, B. S. & Camilleri, M. Elobixibat for the treatment of constipation. Expert Opin. Investig. Drugs 22, 277–284 (2013).

    CAS  PubMed  Article  Google Scholar 

  12. 12.

    Saeed, A. et al. Developments in the synthesis of the antiplatelet and antithrombotic drug (S)-Clopidogrel. Chirality 29, 684–707 (2017).

    CAS  PubMed  Article  Google Scholar 

  13. 13.

    Williams, R. M. & Hendrix, J. A. Asymmetric synthesis of arylglycines. Chem. Rev. 92, 889–917 (1992).

    CAS  Article  Google Scholar 

  14. 14.

    Maruoka, K. & Ooi, T. Enantioselective amino acid synthesis by chiral phase-transfer catalysis. Chem. Rev. 103, 3013–3028 (2003).

    CAS  PubMed  Article  Google Scholar 

  15. 15.

    Najera, C. & Sansano, J. M. Catalytic asymmetric synthesis of α-amino acids. Chem. Rev. 107, 4584–4671 (2007).

    CAS  PubMed  Article  Google Scholar 

  16. 16.

    Wang, J., Liu, X.-H. & Feng, X.-M. Asymmetric strecker reactions. Chem. Rev. 111, 6947–6983 (2011).

    CAS  PubMed  Article  Google Scholar 

  17. 17.

    Eftekhari-Sis, B. & Zirak, M. α-Imino esters in organic synthesis: recent advances. Chem. Rev. 117, 8326–8419 (2017).

    CAS  PubMed  Article  Google Scholar 

  18. 18.

    Burk, M. J. & Feaster, J. E. Enantioselective hydrogenation of the C=N group: a catalytic asymmetric reductive animation procedure. J. Am. Chem. Soc. 114, 6266–6267 (1992).

    CAS  Article  Google Scholar 

  19. 19.

    Burk, M. J., Martinez, J. P., Feaster, J. E. & Cosforda, N. Catalytic asymmetric reductive amination of ketones via highly enantioselective hydrogenation of the C=N double bond. Tetrahedran 50, 4399–4428 (1994).

    CAS  Article  Google Scholar 

  20. 20.

    Nunez-Rico, J. L. & Vidal-Ferran, A. [Ir(P-OP)]-Catalyzed asymmetric hydrogenation of diversely substituted C=N-containing heterocycles. Org. Lett. 15, 2066–2069 (2013).

  21. 21.

    Lu, L.-Q., Li, Y., Junge, K. & Beller, M. Relay iron/chiral Brønsted acid catalysis: enantioselective hydrogenation of benzoxazinones. J. Am. Chem. Soc. 137, 2763–2768 (2015).

    CAS  PubMed  Article  Google Scholar 

  22. 22.

    Han, Z., Liu, G., Wang, R., Dong, X.-Q. & Zhang, X. Highly efficient Ir-catalyzed asymmetric hydrogenation of benzoxazinones and derivatives with a Brønsted acid cocatalyst. Chem. Sci. 10, 4328–4333 (2019).

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  23. 23.

    Chen, J. et al. Pd(OAc)2-catalyzed asymmetric hydrogenation of α-iminoesters. Org. Lett. 21, 9060–9065 (2019).

    CAS  PubMed  Article  Google Scholar 

  24. 24.

    Liu, G. et al. Synthesis of chiral α-substituted α-amino acid and amine derivatives through Ni-catalyzed asymmetric hydrogenation. Chem. Commun. 56, 4934–4937 (2020).

    CAS  Article  Google Scholar 

  25. 25.

    Suzuki, A., Mae, M., Amii, H. & Uneyama, K. Catalytic route to the synthesis of optically active β,β-difluoroglutamic acid and β,β-difluoroproline derivatives. J. Org. Chem. 69, 5132–5134 (2004).

    CAS  PubMed  Article  Google Scholar 

  26. 26.

    Wang, Y.-Q., Lu, S.-M. & Zhou, Y.-G. Highly enantioselective Pd-catalyzed asymmetric hydrogenation of activated imines. J. Org. Chem. 72, 3729–3734 (2007).

    CAS  PubMed  Article  Google Scholar 

  27. 27.

    Hou, C.-J., Wang, Y.-H., Zheng, Z., Xu, J. & Hu, X.-P. Chiral phosphine-phosphoramidite ligands for highly efficient Ir-catalyzed asymmetric hydrogenation of sterically hindered N-arylimines. Org. Lett. 14, 3554–3557 (2012).

    CAS  PubMed  Article  Google Scholar 

  28. 28.

    Abe, H., Amii, H. & Uneyama, K. Pd-catalyzed asymmetric hydrogenation of α-fluorinated iminoesters in fluorinated alcohol: a new and catalytic enantioselective synthesis of fluoro α-amino acid derivatives. Org. Lett. 3, 313–315 (2001).

    CAS  PubMed  Article  Google Scholar 

  29. 29.

    Shang, G., Yang, Q. & Zhang, X. Rh-catalyzed asymmetric hydrogenation of α-aryl imino esters: an efficient enantioselective synthesis of aryl glycine derivatives. Angew. Chem. Int. Ed. 45, 6360–6362 (2006).

    CAS  Article  Google Scholar 

  30. 30.

    Hua, X.-H. & Hu, X.-P. Ir-catalyzed asymmetric hydrogenation of α-imino esters with chiral ferrocenylphosphine-phosphoramidite ligands. Adv. Synth. Catal. 361, 5063–5068 (2019).

    Article  CAS  Google Scholar 

  31. 31.

    Li, Y.-Y., Yu, S.-L., Shen, W.-Y. & Gao, J.-X. Iron-, cobalt-, and nickel-catalyzed asymmetric transfer hydrogenation and asymmetric hydrogenation of ketones. Acc. Chem. Res. 48, 2587–2598 (2015).

    CAS  PubMed  Article  Google Scholar 

  32. 32.

    Zhang, Z., Butt, N. A., Zhou, M., Liu, D. & Zhang, W. Asymmetric transfer and pressure hydrogenation with earth-abundant transition metal catalysts. Chin. J. Chem. 36, 443–454 (2018).

    CAS  Article  Google Scholar 

  33. 33.

    Alig, L., Fritz, M. & Schneider, S. First-row transition metal (De)hydrogenation catalysis based on functional pincer ligands. Chem. Rev. 119, 2681–2751 (2019).

    CAS  PubMed  Article  Google Scholar 

  34. 34.

    Liu, Y., Dong, X.-Q. & Zhang, X. Recent advances of nickel-catalyzed homogeneous asymmetric hydrogenation. Chin. J. Org. Chem. 40, 1096–1104 (2020).

    Article  Google Scholar 

  35. 35.

    Agbossou-Niedercorn, F. & Michon, C. Bifunctional homogeneous catalysts based on first row transition metals in asymmetric hydrogenation. Coord. Chem. Rev. 425, 213523 (2020).

    CAS  Article  Google Scholar 

  36. 36.

    Zhang, L., Tang, Y., Han, Z. & Ding, K. Lutidine-based chiral pincer manganese catalysts for enantioselective hydrogenation of ketones. Angew. Chem. Int. Ed. 58, 4973–4977 (2019).

    CAS  Article  Google Scholar 

  37. 37.

    Seo, C. S. G., Tannoux, T., Smith, S. A. M., Lough, A. J. & Morris, R. H. Enantioselective hydrogenation of activated aryl imines catalyzed by an iron(II) P‑NH-P′ complex. J. Org. Chem. 84, 12040–12049 (2019).

    CAS  PubMed  Article  Google Scholar 

  38. 38.

    Hu, Y. et al. Cobalt-catalyzed asymmetric hydrogenation of C=N bonds enabled by assisted coordination and nonbonding interactions. Angew. Chem. Int. Ed. 58, 15767–15771 (2019).

    CAS  Article  Google Scholar 

  39. 39.

    Hu, Y. et al. Nickel-catalyzed asymmetric hydrogenation of 2-amidoacrylates. Angew. Chem. Int. Ed. 59, 5371–5375 (2020).

    CAS  Article  Google Scholar 

  40. 40.

    Du, X. et al. Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids. Nat. Commun. 11, 3239 (2020).

    ADS  CAS  PubMed  PubMed Central  Article  Google Scholar 

  41. 41.

    Zhang, L., Wang, Z., Han, Z. & Ding, K. Manganese-catalyzed anti-selective asymmetric hydrogenation of α-substituted β-ketoamides. Angew. Chem. Int. Ed. 59, 15565–15569 (2020).

    CAS  Article  Google Scholar 

  42. 42.

    Li, B., Chen, J., Zhang, Z., Gridnev, I. D. & Zhang, W. Nickel-catalyzed asymmetric hydrogenation of N-sulfonyl imines. Angew. Chem. Int. Ed. 58, 7329–7334 (2019).

    CAS  Article  Google Scholar 

  43. 43.

    Zhao, X., Zhang, F., Liu, K., Zhang, X. & Lv, H. Nickel-catalyzed chemoselective asymmetric hydrogenation of α,β-unsaturated ketoimines: an efficient approach to chiral allylic amines. Org. Lett. 21, 8966–8969 (2019).

    CAS  PubMed  Article  Google Scholar 

  44. 44.

    Liu, Y., Yi, Z., Tan, X., Dong, X.-Q. & Zhang, X. Nickel-catalyzed asymmetric hydrogenation of cyclic sulfamidate imines: efficient synthesis of chiral cyclic sulfamidates. iScience 19, 63–73 (2019).

    ADS  CAS  PubMed  PubMed Central  Article  Google Scholar 

  45. 45.

    Park, O.-J., Lee, S.-H., Park, T.-Y., Lee, S.-W. & Cho, K.-H. Enzyme-catalyzed preparation of methyl (R)-N-(2,6-dimethylphenyl)alaninate: a key intermediate for (R)-metalaxyl. Tetrahedron.: Asymmetry 16, 1221–1225 (2005).

    CAS  Article  Google Scholar 

  46. 46.

    Deaguero, A. L. & Bommarius, A. S. In situ mixed donor synthesis of ampicillin with ethylene glycol cosolvent. Biotechnol. Bioeng. 111, 1054–1058 (2014).

    CAS  PubMed  Article  Google Scholar 

  47. 47.

    Taniguchi, S., Yano, T., Imaizumi, M. & Manabe, N. Elobixibat, an ileal bile acid transporter inhibitor, induces giant migrating contractions during natural defecation in conscious dogs. Neurogastroenterol. Motil. 30, e13448 (2018).

    PubMed  Article  CAS  Google Scholar 

  48. 48.

    Hargaden, G. C. & Guiry, P. J. Recent applications of oxazoline-containing ligands in asymmetric catalysis. Chem. Rev. 109, 2505–2550 (2009).

    CAS  PubMed  Article  Google Scholar 

  49. 49.

    Yan, S. et al. Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: convergence of structure-based drug design and X-ray crystallographic study. Bioorg. Med. Chem. Lett. 17, 1991–1995 (2007).

    CAS  PubMed  Article  Google Scholar 

  50. 50.

    Duan, Y. et al. Homogenous Pd-catalyzed asymmetric hydrogenation of unprotected indoles: scope and mechanistic studies. J. Am. Chem. Soc. 136, 7688–7700 (2014).

    CAS  PubMed  Article  Google Scholar 

  51. 51.

    Gridnev, I. D. & Dub, P. A. Enantioselection in Asymmetric Catalysis (CRC Press, Boca Raton, London, New York, 2017).

  52. 52.

    Chen, J. & Gridnev, I. D. Size is important: artificial catalyst mimics behavior of natural enzymes. iScience 23, 100960 (2020).

    ADS  CAS  PubMed  PubMed Central  Article  Google Scholar 

  53. 53.

    Imamoto, T. et al. Rigid P-chiral phosphine ligands with tert-butylmethylphosphino groups for rhodium-catalyzed asymmetric hydrogenation of functionalized alkenes. J. Am. Chem. Soc. 134, 1754–1769 (2012).

    CAS  PubMed  Article  Google Scholar 

  54. 54.

    Gridnev, I. D. & Imamoto, T. Challenging the major/minor concept in Rh-catalyzed asymmetric hydrogenation. ACS Catal. 5, 2911–2915 (2015).

    CAS  Article  Google Scholar 

Download references

Acknowledgements

The authors would like to thank National Key R&D Program of China (No. 2018YFE0126800), National Natural Science Foundation of China (Nos. 21620102003, 21991112, 21702134), Shanghai Municipal Education Commission (No. 201701070002E00030), and Science and Technology Commission of Shanghai Municipality (19JC1430100) for financial support. We thank the Instrumental Analysis Center of SJTU for characterization.

Author information

Affiliations

Authors

Contributions

D.L. conducted most of the synthetic experiments. B.L. conducted part of the synthetic experiments. I.D.G. conducted the DFT computational study. D.L., B.L., J.C., I.D.G., and W.Z. wrote the manuscript. D.Y. took part in the discussion. W.Z. directed the project.

Corresponding author

Correspondence to Wanbin Zhang.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Peer review information Nature Communications thanks Gen-Qiang Chen and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Liu, D., Li, B., Chen, J. et al. Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines. Nat Commun 11, 5935 (2020). https://doi.org/10.1038/s41467-020-19807-5

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing