Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives

Abstract

Triazolopyridinone derivatives are of high value in both medicinal and material chemistry. However, the chiral or hindered triazolopyridinone derivatives remain an underexplored area of chemical space because they are difficult to prepare via conventional methods. Here we report an electrochemical rearrangement for the efficient synthesis of otherwise inaccessible triazolopyridinones with diverse alkyl carboxylic acids as starting materials. This enables the efficient preparation of more than 60 functionalized triazolopyridinones under mild conditions in a sustainable manner. This method is evaluated for the late stage modification of bioactive natural products, amino acids and pharmaceuticals, and it is further applied to the decagram scale preparation of enantiopure triazolopyridinones. The control experiments support a mechanism involving an oxidative cyclization and 1,2-carbon migration. This facile and scalable rearrangement demonstrates the power of electrochemical synthesis to access otherwise-inaccessible triazolopyridinones and may find wide application in organic, material and medicinal chemistry.

Introduction

Triazolopyridinone derivatives are of high value for different applications in materials1, pharmaceuticals2,3,4, or agrochemicals4 (Fig. 1a). The primary substituted triazolopyridinone derivatives are widespread and can be prepared by conventional SN2 substitution from the corresponding triazolopyridinones and halides (Fig. 1b). However, there are only scarce reports about the synthesis of secondary substituted triazolopyridinone derivatives due to the synthetic challenge associated with elimination side reactions or steric issues, and there are only two articles reported for the access of enantiomerically enriched triazolopyridinones using Mitsunobu (only three examples, no enantiomeric excess (ee) values reported)5 or aza-Michael (only one example in 77% yield and 89% ee, a 2-day reaction)6 conditions, respectively. Moreover, there is no report about the synthesis of sterically hindered tertiary substituted triazolopyridinone derivatives, which still remain underexplored area of chemical space.

Fig. 1: Background and reaction development.
figure1

a Representative bioactive molecules with triazolopyridinone scaffold. b Triazolopyridinone derivatives reported by SciFinder. c Alkyl carboxylic acid activation modes. TM transition metal, FG functional group.

Alkyl carboxylic acids are ubiquitous in every aspect of chemistry, and are widely used as building blocks for chemical synthesis because of their stability, convenience for use, and commercial availability in low cost and diverse structures7,8,9,10,11,12. Previously, alkyl carboxylic acids have been well explored for the Kolbe-type electrolysis13 and decarboxylation via activated Barton or N-hydroxyphthalimide esters14,15,16,17,18,19,20,21,22, which could generate alkyl radicals or carbocations for further coupling reactions (Fig. 1c). However, the atom economy of Barton type decarboxylation is low because of the requirement of activating groups, which were discarded as waste after the reaction. Very recently, Baran et al. reported an elegant synthesis of hindered dialkyl ethers with electrogenerated carbocations generated from alkyl carboxylic acids23, which demonstrates the power of electrochemistry to substantially improve the synthetic efficiency24,25,26,27,28,29,30,31,32,33,34. Rearrangement reactions through a molecular skeletal reorganization are powerful chemical transformations for generating structural complexity and diversity35,36,37,38,39. Based on our research experience in the development of C–C or C–X bond forming methodologies via electrochemistry40,41,42, we envisioned that the in situ or isolated hydrazides, prepared from diverse alkyl carboxylic acids and 2-hydrazinopyridines, might undergo an atom/step-economical rearrangement to afford those otherwise-inaccessible triazolopyridinone derivatives under metal and external oxidant free electrochemical conditions (Fig. 1c). Here, we show that an electrochemical rearrangement involving a tandem oxidative cyclization and 1,2-carbon migration was developed for the efficient synthesis of valuable (enantiopure) triazolopyridinone derivatives.

Results

Reaction optimization

As a proof-of-principle study, we began our condition optimization with the isolated hydrazide as substrate, which was readily prepared from 2-phenylacetic acid and 2-hydrazinopyridine (see Supplementary Table 1). After extensive screening, it was found the reaction in a simple undivided cell led to the desired product 1 in 99% yield (graphite anode, platinum cathode, tris(p-bromophenyl)amine ((4-Br-C6H4)3N, 10 mol%) as the redox catalyst, tetrabutylammonium tetrafluoroborate as the supporting electrolyte, MeOH, 70 °C), and the structure of triazolopyridinone product 1 was further confirmed by single crystal X-ray diffraction analysis (Fig. 2).

Fig. 2: Substrate scope and late stage modifications via electrochemical rearrangement.
figure2

aReaction conditions: undivided cell, graphite rod (ϕ 6 mm), Pt cathode (1 cm × 1 cm), hydrazide (0.3 mmol), nBu4NBF4 (0.5 mmol), MeOH (10 mL), 70 °C, 1.8 h (2.2 F/mol); bYield for one-pot reaction with in situ hydrazide; c40 °C. Ac acetyl, Boc tert-butyloxycarbonyl, PMP 4-methoxyphenyl, TBS tert-butyldimethylsilyl.

Evaluation of substrate scope

With optimized conditions in hand, the substrate scopes of this rearrangement reaction were evaluated as shown in Fig. 2. First, inexpensive primary carboxylic acids with a benzyl substituent attached to the acid functionality were tested, and all gave the corresponding products in moderate to excellent yields (222). The substrates with electron-donating groups on the benzene ring (24, 1215) afforded the corresponding products in much higher yields than those with electron-withdrawing groups (58, 1011). The substrates with a naphthyl, thienyl, or allylic substituent were also effective, albeit in lower yields (2224). Next, the secondary alkyl carboxylic acids were tested (2534). The substrates with either alkyl or phenyl substituents at the benzyl position all gave the corresponding products in excellent yields (2529). Substrates with a heteroatom at the α-C were also effective although the yields dropped, probably because of the inductive effect of the heteroatom (3034). The tertiary carboxylic acids such as simple alkyl substituted (3537), deuterated (38), fluorinated (39), and cyclic systems (4144) were demonstrated effective as well. It is worth to mention that these tertiary substituted triazolopyridinone derivatives had never been reported before, and they cannot be prepared by the conventional nucleophilic substitution from the corresponding 1,2,4-triazolo[4,3-a]pyridin-3(2H)-one and alkyl halides (see Supplementary methods). Finally, this protocol was successfully applied for the late stage modification of pharmaceuticals (4550), amino acids (5152), and natural products (5354), which would provide an efficient and fast way to prepare their analogs for structure and activity relationship studies in medicinal chemistry. As demonstrated above, this reaction exhibits broad functional group tolerance such as aryl and alkyl halides (F: 5, 39 and 46; Cl: 6, 16, 20, 27, 37, 45, and 49; Br: 7; I: 17), ethers (3–4, 12–13, 3033, and 49–50), esters (19, 30, and 54), ketone (47–48), enone (54), olefin (24), protected amines (34, 43, 45, 51–52), etc., which provide functional handles for further diverse transformations. This protocol also can be conducted without isolation of the hydrazide though the overall yields (in the brackets) are a little bit lower. It worth to mention that these drug-like triazolopyridinone derivatives have been reported with a wide range of biological activities such as antidepressant, antidiabetic, glycogen synthase kinase-3 inhibitor, late sodium current inhibitor, herbicidal, etc2,3,43,44,45,46,47,48. The successful development of this rearrangement would inspire more exploration on their chemical space and applications.

Synthetic applications

A series of optically pure hydrazide substrates were then synthesized from chiral acid containing molecules including amino acids (51 and 52) and best-selling drugs (5560) to verify whether the configuration could be retained in this rearrangement if the migrating terminus has a stereocenter (Fig. 3a). As a result, the corresponding cyclized products were obtained under the standard conditions with high yields and excellent ee. The stereochemistry of (S)-59 was determined unambiguously by X-ray crystallographic analysis, which indicate the products were obtained with retention of configuration. It is worth to mention that this is one of the few rearrangements, which can retain the stereochemistry successfully, and those drug-like (chiral) enantiopure triazolopyridinone derivatives are difficult to make by conventional methods, and are of high value for drug discovery.

Fig. 3: Synthetic applications of this electrochemical rearrangement.
figure3

a Synthesis of chiral triazolopyridinone derivatives. b Synthesis of stearoyl-CoA desaturase inhibitor analog. c Synthesis of antidepressant drug trazodone analog. d Large scale synthesis.

To further demonstrate the synthetic utility of this protocol, we first applied this rearrangement as key step for the synthesis of stearoyl-CoA desaturase inhibitor analog 63 (Fig. 3b)47. Under the standard conditions the hydrazide 61 was converted to the key intermediate 62 in 70% yield, which was further transformed into 63 by hydrolysis and condensation in 97% overall yield. Next, we applied it for the synthesis of hindered triazolopyridinone compound 67, which is an otherwise-inaccessible analog of top-selling drug antidepressant trazodone (Fig. 3c). The chloride 65 was prepared efficiently from hydrazide 64 under the standard electrochemical conditions, which was then coupled with the piperazine compound 66 to give the trazodone analog 67 successfully. It was indicated that this methodology could be used for the efficient synthesis of previously inaccessible trazodone analogs3. Finally, the gram or even decagram scale reaction of 68 was conducted and the desired enantiopure product (S)-60 was readily obtained in good yield and excellent ee (Fig. 3d), which demonstrated the scalability of this powerful rearrangement.

Mechanistic studies

In order to better understand the mechanism of this rearrangement, a series of control experiments were conducted (Fig. 4). First, a crossover experiment with a mixture of 69 and 70 as the substrates was conducted, and it was found that no crossover products were obtained. This experiment demonstrated the rearrangement must be an intramolecular reaction (Fig. 4a). Second, various additives were tested for this rearrangement with hydrazide 71 as substrate, and it was found the addition of radical scavengers (BHT and TEMPO), H-atom donors (triethylsilane or 1,4-cyclohexadiene) or acetic acid did not inhibit the reaction (Fig. 4b). Third, the radical-clock experiments with 72 and 75 as the substrates gave the corresponding rearranged products 73 and 76, respectively without the detection of ring forming or opening products 74 and 77, which indicated this rearrangement might not involve a radical mechanism (Fig. 4c). Then, with hydrazide 78 as substrate the cyclized product 79 was obtained without detection of 1,2-hydride shift product 80, which showed the stepwise carbocation formation might not operate for this rearrangement (Fig. 4d). Finally, with hydrazide 81 as substrate, it was found that a diazo byproduct 83 was isolated in 27% yield along with the rearrangement product 82 in 58% yield with the hydrolysis of phthalimide ring (Fig. 4e). Interestingly, treatment of the diazo compound 83 in MeOH under reflux for 24 h, gave the rearrangement product 82 in 79% yield, which indicated that this rearrangement might take place via the diazo intermediate. Based on the above control experiments and cyclic voltammetry experiments, a reaction mechanism was proposed: by electrochemical oxidation, a trans-diazo intermediate might form which would readily interconvert with its cis-diazo species because of low energy barrier. Followed by the nucleophilic addition of nitrogen to the carbonyl group and a 1,2-alkyl shift from carbon to nitrogen would afford the desired cyclized product (see Supplementary Fig. 18).

Fig. 4: Control experiments and mechanistic probes.
figure4

a Crossover experiments. b Impact of additives. c Radical-clock experiments. d Control experiment to demonstrate no electrogenerated carbocation formation. e Key intermediate isolation.

This activation mode of carboxylic acids opens the door to convert the diverse and cheap alkyl carboxylic acids into otherwise-inaccessible high value triazolopyridinone derivatives via a highly sustainable electrochemical rearrangement. It is anticipated that this powerful rearrangement will inspire more new findings and find various applications in future.

Methods

General procedure for the electrochemical rearrangement reaction

Further experimental details are provided in the Supplementary Information.

General procedure for the electrochemical synthesis of compound 1. A 10-mL three-necked round-bottomed flask was equipped with a graphite carbon anode (ϕ 6 mm, about 1 cm immersion depth in solution), a platinum plate (1 cm × 1 cm) cathode and a stirring bar. The flask was charged with hydrazide 71 (0.3 mmol, 1 equiv.), tris(p-bromophenyl)amine (0.03 mmol, 10 mol%), nBu4NBF4 (0.5 mmol), and MeOH (10 mL). The reaction mixture was stirred and electrolyzed at a constant current of 10 mA under 70 °C for 1.8 h (2.2 F/mol). When the reaction was finished, the reaction mixture was transferred to a single-necked flask and concentrated under reduced pressure. The resulting residue was washed with water and extracted with EtOAc (3 × 20 mL). The combined organic solution was dried over anhydrous Na2SO4 and concentrated under reduced pressure. The given crude was purified by column chromatography through silica gel to provide the desired product 1 in 99% yield. Full experimental details and characterization of new compounds can be found in the Supplementary Information.

Data availability

The X-ray crystallographic coordinates for structures reported in this article have been deposited at the Cambridge Crystallographic Data Centre (CCDC), under deposition numbers CCDC 1951129 (1) and 1951212 (S-59). These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via http://www.ccdc.cam.ac.uk/data_request/cif. The data supporting the findings of this study are available within the article and its Supplementary information files. Any further relevant data are available from the authors on request.

References

  1. 1.

    Lee, C.-L., Lee, W.-H. & Yang, C.-H. The effects of co-sensitization in dye-sensitized solar cells. J. Mater. Sci. 48, 3448–3453 (2013).

    ADS  CAS  Google Scholar 

  2. 2.

    Alhaider, A. A., Abdelkader, M. A. & Lien, E. J. Design, synthesis, and pharmacological activities of 2-substituted 4-phenylquinolines as potential antidepressant drugs. J. Med. Chem. 28, 1394–1398 (1985).

    CAS  PubMed  Google Scholar 

  3. 3.

    Giannangeli, M. et al. Effect of modifications of the alkylpiperazine moiety of trazodone on 5HT2A and α1 receptor binding affinity. J. Med. Chem. 42, 336–345 (1999).

    CAS  PubMed  Google Scholar 

  4. 4.

    Dinges, J. & Lamberth, C. Bioactive Heterocyclic Compound Classes: Pharmaceuticals. (Wiley-VCH, Weinheim, 2012).

    Google Scholar 

  5. 5.

    Sattigeri, J. A. et al. Efficient one-step synthesis of a key intermediate for the synthesis of azole antifungals using the Mitsunobu protocol. Synth. Commun. 35, 2939–2943 (2005).

    CAS  Google Scholar 

  6. 6.

    Silvi, M. et al. Enantioselective aza-Michael addition of imides by using an integrated strategy involving the synthesis of a family of multifunctional catalysts, usage of multiple catalysis, and rational design of experiment. Chem. Eur. J. 19, 9973–9978 (2013).

    CAS  PubMed  Google Scholar 

  7. 7.

    Gooßen, L. J., Rodríguez, N. & Gooßen, K. Carboxylic acids as substrates in homogeneous catalysis. Angew. Chem. Int. Ed. 47, 3100–3120 (2008).

    Google Scholar 

  8. 8.

    Rodríguez, N. & Gooßen, L. J. Decarboxylative coupling reactions: a modern strategy for C-C-bond formation. Chem. Soc. Rev. 40, 5030–5048 (2011).

    PubMed  Google Scholar 

  9. 9.

    Liang, Y., Zhang, X. & MacMillan, D. W. C. Decarboxylative sp3 C–N coupling via dual copper and photoredox catalysis. Nature 559, 83–88 (2018).

    ADS  CAS  PubMed  PubMed Central  Google Scholar 

  10. 10.

    Xuan, J., Zhang, Z. G. & Xiao, W. J. Visible-light-induced decarboxylative functionalization of carboxylic acids and their derivatives. Angew. Chem. Int. Ed. 54, 15632–15641 (2015).

    CAS  Google Scholar 

  11. 11.

    Weaver, J. D., Recio, A., Grenning, A. J. & Tunge, J. A. Transition metal-catalyzed decarboxylative allylation and benzylation reactions. Chem. Rev. 111, 1846–1913 (2011).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. 12.

    Perry, G. J. P. & Larrosa, I. Recent progress in decarboxylative oxidative cross-coupling for biaryl synthesis. Eur. J. Org. Chem. 25, 3517–3527 (2017).

    Google Scholar 

  13. 13.

    Schäfer, H. J. Recent contributions of Kolbe electrolysis to organic synthesis. Top. Curr. Chem. 152, 91–151 (1990).

    Google Scholar 

  14. 14.

    Saraiva, M. F., Couri, M. R. C., Hyaric, M. L. & de Almeida, M. V. The Barton ester free-radical reaction: a brief review of applications. Tetrahedron 65, 3563–3572 (2009).

    CAS  Google Scholar 

  15. 15.

    Murarka, S. N-(acyloxy)phthalimides as redox-active esters in cross-coupling reactions. Adv. Synth. Catal. 360, 1735–1753 (2018).

    CAS  Google Scholar 

  16. 16.

    Qin, T. et al. A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents. Science 352, 801–805 (2016).

    ADS  CAS  PubMed  PubMed Central  Google Scholar 

  17. 17.

    Cornella, J. et al. Practical Ni-catalyzed aryl-alkyl cross-coupling of secondary redox-active esters. J. Am. Chem. Soc. 138, 2174–2177 (2016).

    CAS  PubMed  PubMed Central  Google Scholar 

  18. 18.

    Wang, J. et al. Nickel-catalyzed cross-coupling of redox-active esters with boronic acids. Angew. Chem. Int. Ed. 55, 9676–9679 (2016).

    CAS  Google Scholar 

  19. 19.

    Li, C. et al. Decarboxylative borylation. Science 356, eaam7355 (2017).

    PubMed  PubMed Central  Google Scholar 

  20. 20.

    Fawcett, A. et al. Photoinduced decarboxylative borylation of carboxylic acids. Science 357, 283–286 (2017).

    ADS  CAS  PubMed  Google Scholar 

  21. 21.

    Candish, L., Teders, M. & Glorius, F. Transition-metal-free, visible-light-enabled decarboxylative borylation of aryl N-hydroxyphthalimide esters. J. Am. Chem. Soc. 139, 7440–7443 (2017).

    CAS  PubMed  Google Scholar 

  22. 22.

    Fu, M.-C., Shang, R., Zhao, B., Wang, B. & Fu, Y. Photocatalytic decarboxylative alkylations mediated by triphenylphosphine and sodium iodide. Science 363, 1429–1434 (2019).

    ADS  CAS  PubMed  Google Scholar 

  23. 23.

    Xiang, J. et al. Hindered dialkyl ether synthesis with electrogenerated carbocations. Nature 573, 398–402 (2019).

    ADS  CAS  PubMed  PubMed Central  Google Scholar 

  24. 24.

    Yan, M., Kawamata, Y. & Baran, P. S. Synthetic organic electrochemical methods since 2000: on the verge of a renaissance. Chem. Rev. 117, 13230–13319 (2017).

    CAS  PubMed  PubMed Central  Google Scholar 

  25. 25.

    Jiang, Y., Xu, K. & Zeng, C. Use of electrochemistry in the synthesis of heterocyclic structures. Chem. Rev. 118, 4485–4540 (2018).

    CAS  PubMed  Google Scholar 

  26. 26.

    Yoshida, J.-I., Shimizu, A. & Hayashi, R. Electrogenerated cationic reactive intermediates: the pool method and further advances. Chem. Rev. 118, 4702–4730 (2018).

    CAS  PubMed  Google Scholar 

  27. 27.

    Moeller, K. D. Using physical organic chemistry to shape the course of electrochemical reactions. Chem. Rev. 118, 4817–4833 (2018).

    CAS  PubMed  Google Scholar 

  28. 28.

    Nutting, J. E., Rafiee, M. & Stahl, S. S. Tetramethylpiperidine N‑oxyl (TEMPO), phthalimide N‑oxyl (PINO), and related N‑oxyl species: electrochemical properties and their use in electrocatalytic reactions. Chem. Rev. 118, 4834–4885 (2018).

    CAS  PubMed  PubMed Central  Google Scholar 

  29. 29.

    Wiebe, A. et al. Electrifying organic synthesis. Angew. Chem. Int. Ed. 57, 5594–5619 (2018).

    CAS  Google Scholar 

  30. 30.

    Tang, S., Liu, Y. & Lei, A. Electrochemical oxidative cross-coupling with hydrogen evolution: a green and sustainable way for bond formation. Chem 4, 27–45 (2018).

    CAS  Google Scholar 

  31. 31.

    Fu, N., Sauer, G. S., Saha, A., Loo, A. & Lin, S. Metal-catalyzed electrochemical diazidation of alkenes. Science 357, 575–579 (2017).

    ADS  CAS  PubMed  Google Scholar 

  32. 32.

    Cai, C.-Y., Shu, X.-M. & Xu, H.-C. Practical and stereoselective electrocatalytic 1,2-diamination of alkenes. Nat. Commun. 10, 4953 (2019).

    ADS  PubMed  PubMed Central  Google Scholar 

  33. 33.

    Yang, Q.-L. et al. Electrochemistry-enabled Ir-catalyzed vinylic C–H functionalization. J. Am. Chem. Soc. 141, 18970–18976 (2019).

    CAS  PubMed  Google Scholar 

  34. 34.

    Kong, W.-J., Shen, Z., Finger, L. H. & Ackermann, L. Electrochemical access to aza-polycyclic aromatic hydrocarbons: Rhoda-electrocatalyzed domino annulations. Angew. Chem. Int. Ed. 59, 5551–5556 (2019).

    Google Scholar 

  35. 35.

    Song, Z.-L., Fan, C.-A. & Tu, Y.-Q. Semipinacol rearrangement in natural product synthesis. Chem. Rev. 111, 7523–7556 (2011).

    CAS  PubMed  Google Scholar 

  36. 36.

    Korb, M. & Lang, H. The anionic Fries rearrangement: a convenient route to ortho-functionalized aromatics. Chem. Soc. Rev. 48, 2829–2882 (2019).

    CAS  PubMed  Google Scholar 

  37. 37.

    Martín Castro, A. M. Claisen rearrangement over the past nine decades. Chem. Rev. 104, 2939–3002 (2004).

    PubMed  Google Scholar 

  38. 38.

    Wu, H., Andres, R., Wang, Q. & Zhu, J. Catalytic enantioselective α-ketol rearrangement. Angew. Chem. Int. Ed. 58, 499–503 (2019).

    CAS  Google Scholar 

  39. 39.

    Wu, H., Wang, Q. & Zhu, J. Recent advances in catalytic enantioselective rearrangement. Eur. J. Org. Chem. 10, 1964–1980 (2019).

    Google Scholar 

  40. 40.

    Ye, Z. et al. Electrochemical synthesis of 1,2,4-triazole-fused heterocycles. Green Chem. 20, 1732–1737 (2018).

    CAS  Google Scholar 

  41. 41.

    Ye, Z., Wang, F., Li, Y. & Zhang, F. Electrochemical synthesis of tetrazoles via metal- and oxidant-free [3 + 2] cycloaddition of azides with hydrazones. Green Chem. 20, 5271–5275 (2018).

    CAS  Google Scholar 

  42. 42.

    Li, Y., Ye, Z., Chen, N., Chen, Z. & Zhang, F. Intramolecular electrochemical dehydrogenative N–N bond formation for the synthesis of 1,2,4- triazolo[1,5-a]pyridines. Green Chem. 21, 4035–4039 (2019).

    CAS  Google Scholar 

  43. 43.

    Guo, C. et al. The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties. Bioorg. Med. Chem. 22, 3414–3422 (2014).

    CAS  PubMed  Google Scholar 

  44. 44.

    Koltun, D. O. et al. Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine. Bioorg. Med. Chem. Lett. 26, 3207–3211 (2016).

    CAS  PubMed  Google Scholar 

  45. 45.

    Liu, X. H. et al. Facile and efficient synthesis and herbicidal activity determination of novel 1,2,4-triazolo[4,3-a]pyridin-3(2H)-one derivatives via microwave irradiation. Bioorg. Med. Chem. Lett. 25, 5524–5528 (2015).

    CAS  PubMed  Google Scholar 

  46. 46.

    Chun, K. et al. Synthesis and evaluation of 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives as glycogen synthase kinase-3 (GSK-3) inhibitors. Bioorg. Med. Chem. Lett. 23, 3983–3987 (2013).

    CAS  PubMed  Google Scholar 

  47. 47.

    Koltun, D. & Zablocki, J. Triazolopyridinone derivatives for use as stearoyl CoA desaturase inhibitors. U.S. patent no. US20090253738A1 (2009).

  48. 48.

    Sun, C. et al. Triazolopyridine derivatives as cannabinoid receptor 1 antagonists. International patent no. WO2006138695Al (2006).

Download references

Acknowledgements

This research was funded by National Natural Science Foundation of China (NSFC, 21871234), and Zhejiang Provincial NSFC for Distinguished Young Scholars (LR15H300001). We thank Profs. Yongqiang Tu (Lanzhou Univ.), Jieping Zhu (EPFL), Matthew Gaunt (Cambridge Univ.), and John Moses (La Trobe Univ.) for helpful discussion.

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Z.Y., Y.W., and F.Z. conceived the project, designed the experiments, and analyzed the data. Z.Y., N.C., H.Z., K.Z., M.D., M.L., and Y.L., performed the experiments. F.Z. wrote the paper with the help of co-authors.

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Correspondence to Fengzhi Zhang.

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Ye, Z., Wu, Y., Chen, N. et al. Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives. Nat Commun 11, 3628 (2020). https://doi.org/10.1038/s41467-020-17389-w

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