The economics of malaria control in an age of declining aid

Article metrics

Abstract

This article examines financing in the fight against malaria. After briefly describing malaria control plans in Africa since 2000, it offers a stylized model of the economics of malaria and shows how health aid can help escape the malaria trap.

Introduction

It is more than a decade since the report from the Committee on the Economics of Antimalarial Drugs, led by Nobel Laureate Kenneth Arrow was published1. Several studies have since shown that worldwide malaria deaths declined dramatically between 2000 and 20142. This massive reduction in malaria-related mortality may have effects that reach beyond health. Improving early childhood health paves the way for greater human capital accumulation, changed fertility patterns, and faster economic development. A decline in malaria can thus generate a wide range of outcomes, many of them positive.

However, interventions across the varied epidemiological settings of Africa remain poorly understood. Two influential articles have been recently published to improve our understanding3,4. To assess the change in malaria prevalence from 2000 to 2015 and to quantify the effects of malaria control, these articles use a large consolidated database from field surveys and combine this database with program data to fight against malaria. They find that the prevalence of Plasmodium falciparum infections in Africa decreases by half between 2000 and 2015. Malaria mortality rates also fell by 57% during the period. These studies interpret these results as the effect of malaria control programs and consider that among control measures, insecticide-treated nets were the most effective. They alone contribute to 68% of the progress made. These two studies provide the best estimates to date.

However, according to the 2018 World Malaria Report, the estimated number of malaria cases worldwide was 219 million in 2017 (216 million in 2016). Data for 2015−2017 show no significant progress towards reducing the number of malaria cases worldwide and the malaria mortality reduction rate has also slowed (435,000 deaths in 2017)5. While these data and their quality are to be considered with caution, this stunt in the fight against malaria is attributed in part by the World Health Organization (WHO) to insufficient investments to achieve the objectives of the Global Technical Strategy for malaria 2016−2030 (GTS), namely to reduce by at least 40% malaria-specific mortality compared to 2015. Investment stagnates indeed since 2010 while the needs remain considerable and many researchers have sent out alarm signals6,7.

This article examines financing in the fight against malaria. After briefly describing malaria control plans in Africa since 2000, it offers a stylized model of the economics of malaria and shows how foreign health aid might help escape the disease trap.

Results

A stylized model of malaria and health aid

We focus on the basic reproductive number under control (PfRc), within the limits of stable Plasmodium falciparum transmission, which provides the potential for the disease to spread within a naive population moderated by malaria control. The estimates of PfRc were generated by the Malaria Atlas Project using a malaria transmission model to describe the relationship between PfRc and the predicted probability distribution of parasite prevalence. Figure 1 shows the average PfRc, using data from the Malaria Atlas project including 42 African countries from 2000 to 2016. Though the estimates of PfRc encapsulate uncertainty in both the underlying prevalence estimates and in the parameterization of the malaria transmission model, it is probably the best estimate at hand3.

Fig. 1
figure1

PfRc (geometric mean from the Malaria Atlas Project-MAP) and predicted PfRc (geometric mean from authors' predictions). The figure provides a static simulation of the model, as a simplified prediction of PfRc compared to the true values of PfRc provided by the Malaria Atlas Project. The blue line provides estimates from a standard fixed-effects model (within country). The orange line provides estimates from the Arellano−Bond model. The green line provides the Malaria Atlas Project PfRc

To understand the effects of malaria aid on the basic reproductive number under control, we start from Berthélemy and Thuilliez, who consider R0 as a natural reproductive number and add individual protective decisions through a utility maximization program8. As usual, if R0Natural is lower than 1, the disease converges toward elimination, which is far from the case today (Fig. 1, green line), even when taking control programs into account. From an economic perspective, PfRc can be considered as the result of the natural basic reproductive number multiplied by the proportion of unprotected population:

$${\mathrm{PfRc}} = {{R}}_{0\,{\mathrm{Natural}}}(1 - {{H}}),$$
(1)

where H is the aggregate protection in the population that could be thought as the use of LLINs.

The fast reduction of PfRc observed from 2000 to 2015 can be primarily considered as the positive result of Roll Back Malaria campaigns using protection tools such as LLINs—that is, an increase in H. Before the campaign, protection was relatively scarce. From an economic point of view, consider gradual increases in H as the result of adopting innovation. In economic analyses, such processes of adoption follow an ordinary logistic function, which is of course S-shaped. As a result, we model the dynamics of H as follows:

$$\frac{{{\mathrm{d}{\it{H}}}}}{{{\mathrm{d}{\it{t}}}}} = {{H}}[ {{{\alpha }} - {{\beta H}}}],\,{{\alpha }} \le {{\beta }}.$$
(2)

In the long run, H converges to \({\mathrm{\alpha }}/{\mathrm{\beta }}\). Note that in an equality, H tends to 1 and PfRc tends to 0. As a result, the rate of growth of PfRc is a nonlinear function of PfRc.

$$\frac{{{\mathrm{dPfRc}}}}{{{\mathrm{d}{\it{t}}}}} = {\mathrm{PfRc}}\left[ - {{R}}_{0{\mathrm{Natural}}}\left( {\frac{{{{\alpha }} - {{\beta }}}}{{{\mathrm{PfRc}}}}} \right) + \frac{{{\beta }}}{{{{R}}_{0{\mathrm{Natural}}}}}{\mathrm{PfRc}} + {{\alpha }} - 2{{\beta }}\right].$$
(3)

The derivative of the growth rate of PfRc is: \(\frac{{{{R}}_{0\,{\mathrm{Natural}}}\left( {{{\alpha }} - {{\beta }}} \right)}}{{{\mathrm{PfRc}}^2}} + \frac{{{\beta }}}{{{{R}}_{0\,{\mathrm{Natural}}}}}\). It follows that for low values of H (PfRc close to R0Natural, H close to 0), dH > 0 and dPfRc < 0. Symmetrically, for large values of H (R0Natural close to 0, H close to 1), dH ≤ 0 and dPfRc ≥ 0.

Put differently, solving Eq. (3) at time independent equilibrium yields the solution of either \({\mathrm{PfRc}} = {{R}}_{0\,{\mathrm{Natural}}}\) (which is unstable for \({\mathrm{\alpha }}{\kern 2pt} > {\kern 2pt} 0\)) and \({\mathrm{PfRc}} = {{R}}_{0\,{\mathrm{Natural}}}\left(1 - \frac{{{\alpha }}}{{{\beta }}}\right)\), which is stable for \({{\alpha }}{\kern 2pt} > {\kern 2pt} 0\) and \(\alpha < 1\) (the condition for elimination) when \({{R}}_{0{\mathrm{Natural}}}\left( {1 - \frac{{{\alpha }}}{{{\beta }}}} \right) < 1\). Thus, a poverty trap exists when \({{R}}_{0{\mathrm{Natural}}}\left( {1 - \frac{{{\alpha }}}{{{\beta }}}} \right) \ge 1\).

This result is important because it shows that with the current strategy and even with a scale-up of LLINs, eliminating malaria is improbable because, for high protection coverage (large values of H), PfRc will tend to increase. The persistence of such a health trap, associated with \({{R}}_{0{\mathrm{Natural}}}\left( {1 - \frac{{{\alpha }}}{{{\beta }}}} \right) > {\kern 2pt} 1\)—with a long run PfRc higher than 1—suggests that without intervention (through aid), it will be impossible to get out of the trap, unless very large amounts of aid are invested, assuming that aid increases adoption and coverage of LLINs—although use of interventions is less well understood—and then increases α.

The argument is not that only a big push could solve this situation, but that reducing the cost of adoption of innovations by households through aid interventions may contribute to increase LLINs’ coverage—possession and use—and reduce the long-run PfRc. There are certainly other demand-side barriers and opportunity costs associated with LLINs usage that may constrain the scale-up of LLINs’ coverage. Reducing malaria aid would thus be catastrophic as supported by dynamic modeling papers where a “reverse” or counterfactual scenario is explored9.

Illustration

To illustrate how health aid may alleviate this issue partially, we use the panel of 42 sub-Saharan African countries to estimate the following growth model of PfRc and check whether malaria aid may enable escaping such a trap:

$$\begin{array}{l}\ln \left( {{\mathrm{PfRc}}} \right)_{{\mathrm{Country}},{{t}}} \, = \, \delta + {\mathrm{\theta }}_1\ln \left( {{\mathrm{PfRc}}} \right)_{{\mathrm{Country}},{{t}} - 1} \, + \, {\mathrm{\theta }}_2\ln \left( {{\mathrm{PfRc}}} \right)_{{\mathrm{Country}},{{t}} - 1}^2\\ + \, {\mathrm{\theta }}_3{\mathrm{Malaria}}\,{\mathrm{Aid}}_{{\mathrm{Country}},{{t}}} + {\mathrm{\theta }}_4{\mathrm{GDP}}\,{\mathrm{per}}\,{\mathrm{capita}}_{{\mathrm{Country}},{{t}}} + {\mathrm{\varepsilon }}_{{\mathrm{Country}},{{t}}}\end{array}.$$
(4)

Equation (4) is a discretization of the continuous equation given by Eq. (3). Malaria aid data are from WHO–World Malaria Reports and include disbursements from the Global Fund, the World Bank Booster Program, the U.S. President’s Malaria Initiative, and the UK-Aid Department for International Development (DFID). GDP per capita is from WDI and PfRc is from the Malaria Atlas Project. GDP per capita proxies poverty incidence (not available on an annual basis), which can reduce the adoption of protection innovations due to poverty trap mechanisms10,11. We measure dPfRc/PfRc.dt as a logarithmic growth rate, estimated as a quadratic function of ln(PfRc). In an extended version of Eq. (4), we add public expenditure on health from domestic sources per capita expressed in international dollars at purchasing power parity (in PPP; World Development Indicators). We next estimate the equation using a standard fixed-effects model (within country) or an Arellano−Bond model (which helps reduce the endogeneity bias inherent in dynamic fixed-effect estimations).

Results from these stylized models are provided in Table 1. Figure 1 provides a static simulation of the model, as a simplified prediction of PfRc compared to the true values of PfRc provided by the Malaria Atlas Project. Table 1 shows that the predictions of the model are confirmed. The effect of the lagged values of Ln(PfRc) are positive. Predictions also perform well and show that the level of PfRc is far above 1 in all cases. Malaria aid has a significant negative effect on PfRc in Africa, an argument in favor of sustained development assistance, but current levels of malaria aid will not be enough. Dynamic extensions and simulations from our stylized model suggest that a level of aid of US$25−US$30 per capita would be needed to reach a PfRc of 1. This result is in accordance with other estimations made in Africa12, where figures of up to US$20 were estimated for elimination to be possible with current interventions. It has been estimated that in the Asia-Pacific, where malaria incidence is lower, levels of around US$6−US$9 would be required for elimination13. Importantly, the fact that aid has a greater impact than local public health expenditures is an indication of the weakness of national systems—the expenditure financed by aid being certainly better controlled and administered and therefore more effective.

Table 1 Results from fixed-effects and Arellano−Bond estimates of Eq. (4)

Figure 1 suggests a prevention adoption behavior that is S-shaped and has helped reduce PfRc from about 3 initially to about 2 in the long run, which would suggest a long run H of about 33% on average at current levels of aid and GDP per capita. This relatively low potential adoption may be partly explained by a poverty and malaria trap mechanisms8,14,15, in which individuals in a poverty trap would not adopt LLINs even if they are fully subsidized. In recent years the poverty incidence (at $1.90 a day) has on average been as high as 43% in sub-Saharan Africa (according to the data provided by the World Bank Povcalnet website).

Discussion

Of course, the malaria community acknowledges that current level of international funding will not be sufficient to eliminate malaria. However, existing predictions do not illustrate the possibility and the danger of a disease trap. Moreover, the advocacy on malaria aid has not been supported by the community of economists since Sachs et al. or Arrow1,10,11. Our model provides a renewed analysis on malaria aid. It also uses foundations that are anchored in microeconomics to illustrate the conditions of existence of a potential malaria trap. We note that even with health aid, it is unlikely that malaria will be successfully eliminated, which might generate a negative incentive for international funders to invest in malaria control programs. This is due to several factors including the arsenal of currently available tools that may not be sufficient to control malaria to low levels of transmission, sustainability of international funding as countries develop and become wealthier, the role of public financing, malaria epidemiological specificities, among others. Moreover, combinations of tools (including LLINs, insecticides spraying, Intermittent Preventive Treatments and Artemisinin Combination Therapies) are necessary to control malaria. Our model could apply to all of these measures. However, LLINs have crystalized the debate in the economic literature and we believe our stylized model is easier to understand with LLINs alone. The unprotected population could also benefit from positive externalities through those who are protected, as demonstrated for other infectious diseases16. This should increase the effectiveness of both malaria aid and malaria control and reinforce our conclusions, as demonstrated elsewhere8.

To conclude, the poverty–disease-trap mechanisms may help explain a large part of the problem. New international funding sources or innovative financing are unlikely in a near future. Poverty reduction and universal strategies would thus be a natural complement of health aid to help eliminate diseases like malaria. In light of the global economy’s fragile recovery, African countries will need to reset their relationships with international aid agencies and bilateral partners and possibly look more to South–South cooperation and private–public partnerships. Greater coordination of current aid players is therefore needed so that available resources could have higher health impact.

Data availability

All data used for this analysis are freely accessible at Malaria Atlas Project for the PfRc (https://map.ox.ac.uk/), World Development Indicators (https://datacatalog.worldbank.org/dataset/world-development-indicators), and WHO for malaria aid (https://www.who.int/malaria/data/en/). All data were accessed on March 2018. The do file and database used for the analysis are available upon request.

References

  1. 1.

    Arrow, K. J., Panosian, C. & Gelband, H. Saving Lives, Buying Time: Economics of Malaria Drugs in An Age of Resistance (National Academies Press, Washington DC, 2004).

  2. 2.

    Churcher, T. S. et al. Measuring the path toward malaria elimination. Science 344, 1230–1232 (2014).

  3. 3.

    Bhatt, S. et al. The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015. Nature 526, 207–211 (2015).

  4. 4.

    Gething, P. W. et al. Mapping Plasmodium falciparum mortality in Africa between 1990 and 2015. New Engl. J. Med. 375, 2435–2445 (2016).

  5. 5.

    WHO. World malaria report 2018. http://www.who.int/malaria/publications/world-malaria-report-2017/en/ (World Health Organization, Geneva, 2018).

  6. 6.

    Alonso, P. & Noor, A. M. The global fight against malaria is at crossroads. Lancet 390, 2532–2534 (2017).

  7. 7.

    Maxmen, A. Rise in malaria cases sparks fears of a resurgence. Nature doi:10.1038/nature.2017.23046 (2017).

  8. 8.

    Berthélemy, J.-C. & Thuilliez, J. The economics of malaria in Africa. in The Oxford Handbook of Africa and Economics (eds Monga, C. & Lin, J. Y.) (Oxford University Press, Oxford, UK, 2015).

  9. 9.

    Griffin, J. T. et al. Potential for reduction of burden and local elimination of malaria by reducing Plasmodium falciparum malaria transmission: a mathematical modelling study. Lancet Infect. Dis. 16, 465–472 (2016).

  10. 10.

    Gallup, J. L. & Sachs, J. D. The Economic Burden of Malaria. Am. J. Trop. Med. Hyg. 64, 85–96 (2001). https://www.ajtmh.org/content/journals/10.4269/ajtmh.2001.64.85.

  11. 11.

    Sachs, J. & Malaney, P. The economic and social burden of malaria. Nature 415, 680–685 (2002).

  12. 12.

    Walker, P. G. T., Griffin, J. T., Ferguson, N. M. & Ghani, A. C. Estimating the most efficient allocation of interventions to achieve reductions in Plasmodium falciparum malaria burden and transmission in Africa: a modelling study. Lancet Glob. Health 4, e474–e484 (2016).

  13. 13.

    Shretta, R. et al. An investment case for eliminating malaria in the Asia Pacific Region. (The Global Health Group, San Franscisco University of California, San Francisco, 2017). https://www.shrinkingthemalariamap.org/sites/www.shrinkingthemalariamap.org/files/content/page/an-investment-case-for-eliminating-malaria-in-asia-pacific.pdf.

  14. 14.

    Berthélemy, J.-C., Thuilliez, J., Doumbo, O. & Gaudart, J. Malaria and protective behaviours: is there a malaria trap? Malar. J. 12, 200 (2013).

  15. 15.

    Berthélemy, J.-C., Gaudart, J. & Thuilliez, J. Prevention or treatment? The case of malaria. Econ. Lett. 131, 16–19 (2015).

  16. 16.

    Miguel, E. & Kremer, M. Worms: identifying impacts on education and health in the presence of treatment externalities. Econometrica. 72, 159–217 (2004).

Download references

Acknowledgements

This study was funded by the African Development Bank Group; contract no. ECVP/SC/2017/012/014.

Author information

E.M., C.M., J.T., and J.-C.B. designed the study and wrote the report. J.T. and J.-C.B. analyzed the data.

Correspondence to Josselin Thuilliez.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Journal peer review information: Nature Communications thanks Lisa Jane White and other anonymous reviewer(s) for their contribution to the peer review of this work. Peer reviewer reports are available.

Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Maskin, E., Monga, C., Thuilliez, J. et al. The economics of malaria control in an age of declining aid. Nat Commun 10, 2269 (2019) doi:10.1038/s41467-019-09991-4

Download citation

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.