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Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications


Trifluorodiazoethane (CF3CHN2), a highly reactive fluoroalkylating reagent, offers a useful means to introduce trifluoromethyl groups into organic molecules. At present, CF3CHN2 can only be generated by oxidation of trifluoroethylamine hydrochloride under acidic conditions; due to its toxic and explosive nature, its safe generation and use remains a prominent concern, hampering wider synthetic exploitation. Here we report the development of trifluoroacetaldehyde N-tfsylhydrazone (TFHZ-Tfs) as a CF3CHN2 surrogate, which is capable of generating CF3CHN2 in situ under basic conditions. The reaction conditions employed in this chemistry enabled a difluoroalkenylation of X–H bonds (X = N, O, S, Se), affording a wide range of heteroatom-substituted gem-difluoroalkenes, along with Doyle-Kirmse rearrangements and trifluoromethylcyclopropanation reactions, with superior outcomes to approaches using pre-formed CF3CHN2. Given the importance of generally applicable fluorination methodologies, the use of TFHZ-Tfs thus creates opportunities across organic and medicinal chemistry, by enabling the wider exploration of the reactivity of trifluorodiazoethane.


Trifluorodiazoethane (CF3CHN2, also known as trifluoromethyldiazomethane) is a highly reactive trifluoromethylating agent employed in transformations such as cycloadditions1,2,3,4,5,6, X–H insertions7,8, coupling reactions9,10 and homologations (Fig. 1a)11,12. CF3CHN2 is generated by the oxidation of trifluoroethylamine hydrochloride (CF3CH2NH2·HCl) under acidic conditions, but being a toxic and explosive gas, handling of CF3CHN2 at room temperature is extremely hazardous if a significant buildup occurs2,13. Although first described in 194314, only in the last decade have improvements to this method been made, involving slow addition of aqueous NaNO2 to trifluoroethylamine to avoid an accumulation of large amounts of CF3CHN22. More recently, other operational improvements have been developed, such as the small-scale preparation of CF3CHN2 in solution5,7,8, the recycling of gaseous CF3CHN29, and the use of continuous-flow chemistry15,16,17. Nevertheless, the use of specifically designed equipment and/or operating conditions remains a general limitation, and reagents that are easily handled but capable of slowly generating CF3CHN2 in situ under mild conditions (ideally complementing current oxidative/acidic methods) are of high appeal.

Fig. 1

Generation and transformations of trifluorodiazoethane, and synthesis of TFHZ-Tfs. a Synthesis and applications of trifluoromethyldiazomethane (CF3CHN2) in organic synthesis. CF3CHN2 is a highly reactive trifluoroalkylation reagent, but its simplex synthesis method, inherent toxicity and explosiveness limit its widespread application. Because of its hazardous nature, manifold methods have been developed for the safer use of CF3CHN2 such as slow addition of oxidants, small-scale preparation of CF3CHN2 solution, recycling of gaseous CF3CHN2 and continuous-flow chemistry. b Method for the generation of CF3CHN2 from trifluoroacetaldehyde N-tfsylhydrazone under basic condition and gem-difluoroalkenylation of X–H

We targeted the use of trifluorinated N-sulfonylhydrazones as a trifluorodiazoethane surrogate. As a class of stable precursors to diazo compounds, sulfonylhydrazones are widely used in synthesis18,19,20,21,22; however, trifluoroacetaldehyde-derived sulfonylhydrazones have not been explored as surrogates for CF3CHN223,24. gem-Difluoroalkenes are important motifs in the design of mechanism-based enzyme inhibitors, and as bioisosteres of the carbonyl group25,26,27, and are typically prepared by Wittig or Julia–Kocienski-type reactions28,29,30, or by cross-coupling31,32,33,34. However, these methods are mostly effective only for the synthesis of C-substituted gem-difluoroalkenes, while the synthesis of their heteroatom-substituted counterparts is comparatively rare and suffers from narrow substrate scope, or requires strong bases or toxic reagents35,36,37,38,39.

We report here the development of trifluoroacetaldehyde N-tfsylhydrazone (TFHZ-Tfs) as a bench-stable CF3CHN2 precursor, which decomposes in a controlled manner under basic conditions to release CF3CHN2 into the reaction system (Fig. 1b); this strategy circumvents the need for slow addition or manual handling of CF3CHN2, thus minimizing exposure and reducing the potential explosion risk. Importantly, this base-mediated approach also led to the discovery of novel reactivity of CF3CHN2: we describe its use in the difluoroalkenylation of X–H (X = N, O, S, Se) bonds, overcoming limitations in previous routes to these motifs, and also in Doyle–Kirmse and cyclopropanation reactions, which display excellent stereoselectivity and yields, and collectively demonstrate the potential utility of TFHZ-Tfs as a trifluorodiazoethane surrogate.


Synthesis of TFHZ-Tfs

TFHZ-Tfs could be easily accessed by condensation of the o-trifluoromethylbenzenesulfonyl hydrazide with trifluoroacetaldehyde monohydrate under acidic conditions. The reaction proved readily scalable, TFHZ-Tfs could be prepared in high yield (91%) on 85 mmol scale as a bench-stable crystalline solid, and in a cost-effective manner, which is attractive for synthetic applications. In addition, TFHZ-Tfs could be stored at ambient temperature for at least 5 months without degradation (as characterized by 1H NMR spectroscopy).

Investigation of reaction conditions

An exploration of the reactivity of TFHZ-Tfs began in the difluoroalkenylation of X–H bonds. p-Methylthiophenol was identified as a suitable nucleophile for this study, and to our delight we found that in the presence of aqueous KOH, sodium dodecylbenzenesulfonate (SDBS, 30 mol%), and the iron porphyrin catalyst FeTPPCl (5 mol%) in dichloromethane at 40 °C, TFHZ-Tfs delivered the difluoroalkenylated product 2 in 51% yield, along with 9% of the trifluoroethyl thioether 2′ (Fig. 2, Entry 1). Iron porphyrin complexes have been applied as highly efficient catalyst in carbene-transfer reactions40. Screening of other iron porphyrin complexes led to the discovery of the more robust Fe[P2] catalyst, which at just 1 mol% loading afforded 2 in 80% isolated yield, while suppressing the formation of side product 2′ (Entries 2 and 3). Under the same conditions, TFHZ-Ns and TFHZ-Ts gave 2 in significantly lower yield (Entries 4 and 5). Additional optimization of this S–H gem-difluoroalkenylation led to refinement of the reactions parameters (Entry 3, TFHZ-Tfs (2.0 equiv), 5 mL KOH aq. (20 wt%), and SDBS (30 mol%) in the presence of 1 mol% of Fe[P2] in DCM at 40 °C under air; see Supplementary Table 1 for details).

Fig. 2

Optimization of the iron-catalyzed gem-difluoroalkenylation of p-methylthiophenol with trifluoromethyl sulfonylhydrazones. Reaction conditions: thiophenol (0.3 mmol), sulfonylhydrazone (0.6 mmol), Fe porphyrin catalyst, SDBS (sodium dodecylbenzenesulfonate) (0.09 mmol), DCM (1.0 mL), and KOH solution (5.0 mL, 20% wt %), 40 °C, 18 h, under air. aYields determined by 1H NMR spectroscopic analysis with CH2Br2 as an internal standard. bReaction carried out under Ar atmosphere. cYield in parentheses is the isolated yield

Scope of thiol gem-difluoroalkenylation

Having established the decomposition profile of TFHZ-Tfs, and conditions for thiol difluoroalkenylation, the scope of this insertion was explored. Under the optimized conditions of Fig. 2 Entry 3 (Method A), a broad tolerance of arene substituents was observed (Fig. 3), with thiophenols bearing both electron-donating and electron-withdrawing substituents giving the corresponding difluoroalkenes in good to excellent yields (219). Notably, reaction efficiency was not compromised by the positioning of the aryl substituent (ortho, meta, or para), and indeed sterically hindered mono- or bis-ortho-substituted substrates afforded the difluoroalkenes in high yields (2021). Thienyl, furyl, and 2-naphthalene thiols were also excellent substrates, leading to heteroaryl- and naphthyl sulfides 2224. We were pleased to find that benzeneselenol performed equally well, affording the selenodifluoroalkene 25 in 66% yield. The difluoroalkenylated structure was unambiguously confirmed by single crystal X-ray diffraction analysis of sulfone 9′, which was prepared by oxidation of 9 with m-CPBA (see Supplementary Table 7 for X-ray crystallographic data).

Fig. 3

Scope of gem-difluoroalkenylation of X–H (X = N, O, S, Se). Reaction conditions: Method A: thiophenol (0.3 mmol), TFHZ-Tfs (0.6 mmol), Fe[P2] (1 mol%), SDBS (30 mol%), KOH (aq.)/DCM (5:1), air, 40 °C, 18 h. Method B: amine (0.3 mmol), TFHZ-Tfs (0.6 mmol), Cu(OTf)2 (20 mol%), LiOtBu (4 equiv), DCE: toluene (3:1), Ar, 40 °C, 24 h. Method C: TFHZ-Tfs (1.0 mmol), NaH (4 equiv) and DCE (8.0 mL) were stirred at rt for 1 h under Ar, then CuBr (30 mol%), alcohol (0.5 mmol), and LiOtBu (1 equiv) were added and the mixture was stirred at 40 °C under Ar for 24 h. *Reaction performed for 30 h. Number in parentheses is the yield based on recovered starting material (brsm). The yield was determined by 1H NMR spectroscopic analysis with CH2Br2 as an internal standard

Scope of amine gem-difluoroalkenylation

We next questioned whether other heteroatoms could also serve as suitable nucleophilic coupling partners, and turned our attention to amine difluoroalkenylation. After extensive screening of reaction parameters, a copper catalyst system was identified that efficiently mediated this transformation, consisting of Cu(OTf)2 (20 mol%) and LiOt-Bu (4.0 equiv) in DCE:toluene (3:1) under argon at 40 °C (Fig. 3, Method B, see Supplementary Table 2 for details of reaction optimization). The reaction scope encompassed a variety of aniline derivatives, with ring substituents including halides, nitriles, ketones, esters, and anthraquinones, delivering the gem-difluoroenamines in moderate to good yields (2635). In some cases, incomplete conversions were observed, but the residual amine substrate could be recovered. In addition to primary anilines, benzophenone imine proved a viable substrate: product 36 was obtained in 51% yield, suggesting this method could be applied to the N-difluoroalkenylation of other nitrogen-based nucleophiles. Secondary amines did not prove suitable, as shown by the low yield of compound 37.

Scope of alcohol gem-difluoroalkenylation

Further expansion of the scope of the methodology was achieved through modification of the copper catalyst to enable the synthesis of difluorovinyl ethers from alcohols (Fig. 3, Method C, for details of optimization see Supplementary Table 3). A wide selection of benzyl-, alkyl-, and heteroaryl-substituted alcohols afforded gem-difluorovinyl ethers in good to excellent yields; for benzyl alcohols, the position of substituents on the arene had little influence on the reaction outcome (3847), and secondary and tertiary benzyl alcohols also afforded the corresponding products with respectable efficiency (48 and 49). Alkyl alcohols (such as phenethyl and phenylpropyl), and other functionalized alcohols (such as cinnamyl, propargyl, and 2-adamantyl), all proved reactive partners, affording products 5056 in moderate to high yields. In contrast to aliphatic alcohols, phenols showed poor reactivity; for example, 4-biphenylol gave the difluoroalkenylated product 57 in just 20% yield, which presumably reflects the poorer nucleophilicity of the phenol compared to the aliphatic substrate.

Scope of gem-difluoroalkenylation with bioactive molecules

To illustrate potential utility, the methodology was applied to the gem-difluoroalkenylation of selected natural products, drugs, and pharmaceutical intermediates. For instance, various terpene and steroid natural products (nerol, pregnenolone, ergosterol, cholesterol, and stigmasterol) were derivatized into the desired difluorovinyl ethers in good yields (5863). Estradiol benzoate, a highly potent hormone therapy agent used to treat estrogen deficiencies, could also be converted to the corresponding gem-difluoroalkenylated product 64 in 72% yield. Further, the synthesis of gem-difluoroalkenylated vitamin D2 65, (the parent being a potent drug for treatment of cutaneous tuberculosis and lupus erythematosus), was achieved in the presence of its potentially sensitive triene functionality, underlining the functional group tolerance of this methodology. It is notable that fluoroalkyl ethers represent the key structure of many insecticides and lubricants; the ready availability of such gem-difluorovinyl ethers may provide new opportunities for the design and construction of such molecules41.

Gram-scale synthesis and further transformations

For multigram-scale applications, the Fe[P2] catalyst (which requires a multistep synthesis) could be conveniently replaced with the commercially available FeTPPC1 (Fig. 4). Using this alternative catalyst with dichloromethane as solvent, gem-difluorovinyl sulfide 9 was obtained in a yield of 47%, which is comparable to that obtained with Fe[P2] (Method A, 50%). Interestingly, this product could be smoothly mono-defluorinated by treatment with CuCl and B2pin2 to give the (Z)-monofluorovinyl sulfide 66 in 67% yield42; to our knowledge, no other routes to selectively access such monofluorinated alkenyl thioethers are known. Alternative functionalization also proved possible, such as substitution of both fluorines in 9 by reaction with excess p-methoxyphenol in the presence of NaH, affording the trisubstituted olefin 67 in 42% yield43.

Fig. 4

Gram-scale synthesis and further transformations. Gram-scale synthesis of product 9 (1). Mono-defluorination of product 9 (2). Double defluorination of product 9 (3)

Mechanistic investigations

To gain insight into the reaction mechanism, a CF3CHN2 solution in dichloromethane was prepared according to previous reports (Fig. 5, Eq. 4)5, and then treated with 4-methylbenzenethiol under Method A, which led to 2 and 2′ in 48% and 3% yield respectively as detected by 1H NMR analysis of the crude reaction mixture. However, if neutral water was used instead of aqueous KOH, only 2′ was obtained (61%). These results suggest that base plays a crucial role in the gem-difluoroalkenylation reaction, in that it may either facilitate reaction of the heteroatomic nucleophile by deprotonation, and/or may promote a β-F elimination of a reaction intermediate. To confirm that the trifluoroethyl sulfide 2′ is indeed a side product rather than an intermediate, conversion of 2′ into 2 under Method A was attempted, but without success (Eq. 5). This may imply that the reaction mechanism involves direct fluoride ion elimination from a carbenoid-derived species, rather than elimination of HF from the trifluoroethyl group. The observation that (2,2,2-trifluoroethoxy)methylbenzene 68 was also not converted to 38 under Method C (Eq. 6) supports this hypothesis.

Fig. 5

Mechanistic investigations. Base promotes fluoride elimination (4) Intermediate experience verification (5) and (6)

Proposed mechanism

Based on these experimental results, a plausible reaction mechanism is proposed in Fig. 6 in which trifluorodiazoethane is generated in situ from TFHZ-Tfs under the basic reaction conditions, and then reacts with the metal catalyst to form carbenoid intermediate A. The latter is trapped by the substrate (or deprotonated substrate) to form the oxonium ylide B44; Following deprotonation under the basic reaction conditions, the resultant intermediate C undergoes β-fluoride elimination to give the gem-difluoroalkenylation product, regenerating the metal catalyst34,45.

Fig. 6

Proposed mechanism. Mechanistic insights regarding to formation of oxonium ylide and fluoride elimination

Applications of TFHZ-Tfs in Doyle–Kirmse reaction

The high efficiency observed in the difluoroalkenylation encouraged us to test the potential of this reagent in other carbenoid transformations. The Doyle–Kirmse reaction of allyl/propargyl thioethers was first studied, where we were delighted to find that reaction of TFHZ-Tfs with allylic thioethers catalyzed by Fe(TTP)Cl delivered the desired CF3-substituted homoallyl or alkenyl products in excellent yields (Fig. 7)46,47. This reaction offers a direct and powerful method for the construction of C(sp3)–S and C–C bonds by [2,3]-sigmatropic rearrangement of diazo-derived ylids48,49, and again the use of TFHZ-Tfs proved superior for the generation of trifluorodiazoethane compared to the oxidation of trifluoroethylamine50. The scope of this reaction was found to be quite broad, with aryl thioethers containing electron-donating and electron-withdrawing groups at different positions of aryl ring affording CF3-substituted homoallyl products (69–83) in good to excellent yields. Thioethers bearing a disubstituted aryl group also proved suitable, such as a 2,5-dimethylated substituent, which gave product 84 in 84% yield. Naphthyl and heteroaryl allyl thioethers also proceeded efficiently to give the corresponding products 85 and 86 (80% and 75%, respectively). Alkyl allyl thioethers, including benzyl, methyl, and bisallyl substituents, were also well-tolerated to produce the desired products (87–89) in good yields.

Fig. 7

Scope of Doyle–Kirmse reaction. Reaction conditions: thioether (0.3 mmol), TFHZ-Tfs (0.6 mmol), FeTPPCl (3 mol%), NaOH (aq.)/DCM (5:1), 40 °C, 18 h

Scope of Doyle–Kirmse reaction with allyl thioether

The effect of substituents (R1, R2, and R3) on the allyl thioether unit was similarly evaluated, which revealed that the substituent at the 2′-position substituent on the allyl thioether unit (R1) could be varied (methyl, phenyl, or halogen), giving products 90–93 with high efficiency. Equally, a range of 1,2-disubstituted allylic thioethers (R2 = Me/Ph, R3 = H/Me) were compatible, affording products (94–98) with high stereoselectivity (up to 10:1 dr, absolute configuration of major isomers was unambiguously confirmed by single crystal X-ray diffraction analysis of its derivatives, details see Supplementary Table 8). Most noteworthy among these variations is the rearrangement to generate a quaternary carbon center in homoallylic sulfide 96. Moreover, a cyclic olefin-substituted thioether afforded the S-to-C transposition product 99 in 77% yield, with high stereoselectivity (7:1 dr).

Scope of Doyle–Kirmse reaction with propargyl thioether

We next investigated the scope of the Doyle–Kirmse reaction using propargyl thioethers. Pleasingly, aryl, alkyl, fused aryl, and heteroaryl-functionalized propargyl thioethers all reacted smoothly with TFHZ-Tfs to give the expected allene products in good to excellent yields (100103). Internal alkynyl thioethers exhibited outstanding reactivity, as demonstrated by reactions of methyl-, phenyl- and TMS-substituted propargyl thioethers, which gave products 104106 in 72–75% yield.

Applications of TFHZ-Tfs in cyclopropanation

Finally, the application of TFHZ-Tfs as a diazo precursor in cyclopropanation reactions was examined, with the aim of providing an alternative approach to medicinally-relevant trifluoromethylcyclopropanes2,51,52,53,54,55. To our delight, various terminal olefins underwent smooth reaction with TFHZ-Tfs under basic conditions in the presence of Fe(TPP)Cl, giving the desired CF3-substituted cyclopropanes in high yields (Fig. 8). Good functional group tolerance and excellent stereoselectivity (>20:1) were observed: electron-neutral, -rich, and -poor styrenes all underwent efficient cyclopropanations, affording the corresponding trifluoromethylcyclopropane products 107113 in 81–95% yields. Again, naphthyl and heteroaryl groups were accommodated, providing products 114 and 115 in 87% and 81% yields respectively. Other conjugated dienes and enynes were examined, and also generated the corresponding cyclopropanes (116118) in excellent yields. Finally, the use of 1,1-disubstituted olefins was equally well-tolerated in spite of increased steric hindrance, delivering trisubstituted products 119 and 120 without diminishing the reaction efficiency or stereoselectivity.

Fig. 8

Scope of trifluoromethylcyclopropanation. Reaction conditions: olefin (0.3 mmol), TFHZ-Tfs (0.6 mmol), FeTPPCl (3 mol%), NaOH (aq.)/DCM (5:1.5), 40 °C, 22 h


In summary, we report the development of trifluoroacetaldehyde N-tfsylhydrazone (TFHZ-Tfs)—a bench-stable crystalline reagent that represents a versatile trifluorodiazoethane surrogate, which can generate CF3CHN2 under basic conditions in a controlled manner that avoids excessive buildup of the hazardous diazo compound. A number of applications of TFHZ-Tfs are described, including the discovery of gem-difluoroalkenylation of X–H bonds (X = S, N, O, Se), Doyle–Kirmse rearrangements, and trifluoromethylcyclopropanation reactions, with superior performance over other sources of CF3CHN2. Considering the procedural advantages of this trifluorodiazoethane surrogate, and the importance of generally applicable fluorination methodologies, these findings create many opportunities for the wider exploration of the chemistry of trifluorodiazoethane.


General procedure for the synthesis of gem-difluorovinyl thioether

A screw capped reaction vial was charged with TFHZ-Tfs (0.6 mmol), toluenethiol (0.3 mmol), Fe[P2] (0.003 mmol) and SDBS (sodium dodecylbenzenesulphonate) (0.09 mmol) under air, followed by addition of DCM (1.0 mL) and KOH aq. (5.0 mL, 20 wt%) (Fig. 5, Method A) . The resulting mixture was stirred at 40 °C for 18 h. Then 10 mL water was added to the mixture, which was extracted with DCM (3 × 10 mL). The organic layer was combined and dried with anhydrous MgSO4, then filtered through a short silica gel eluting with DCM. The filtrate was evaporated under reduced pressure to leave a crude mixture, which was separated by flash column chromatography to afford the pure product.

General procedure for the synthesis of gem-difluorovinyl amine

A screw capped reaction vial was charged with TFHZ-Tfs (0.6 mmol), amine (0.3 mmol), Cu(OTf)2 (0.06 mmol) and LiOtBu (1.2 mmol), then evacuated and filled with argon for three times, followed by addition of DCE (3.0 mL) and toluene (1.0 mL) via syringe (Fig. 5, Method B). The resulting mixture was stirred at 40 °C for 24 h. The reaction crude was filtered through a short silica gel eluting with DCM. The filtrate was evaporated under reduced pressure to leave a crude mixture, which was separated by flash column chromatography to afford the pure product.

General procedure for the synthesis of gem-difluorovinyl ether

A screw capped reaction vial was charged with TFHZ-Tfs (1.0 mmol), and NaH (60 wt%, 2 mmol) and was evacuated and filled with argon for three times, followed by addition of dry DCE (8.0 mL) via syringe. The resulting mixture was stirred at room temperature for 1 h (Fig. 5, Method C). Then, alcohol (0.5 mmol) and CuBr (0.15 mmol) were added and the system was stirred at 40 °C for 24 h. The reaction crude was filtered through a short silica gel eluting with DCM. The filtrate was evaporated under reduced pressure to leave a crude mixture, which was purified by column chromatography on silica gel.

General procedures for Doyle–Kirmse reaction

A screw capped reaction vial was charged with TFHZ-Tfs (0.6 mmol), FeTPPCl (0.009 mmol), then evacuated and filled with argon for three times, then DCM (1 mL) which dissolved with allyl or propargyl sulfide (0.3 mmol) and NaOH aq. (5 mL, 20 wt%) was successively added by syringe (Fig. 7). The reaction was stirred at 40 °C for 18 h. Then 10 mL water was added to the mixture and layers partitioned. The aqueous layer was extracted with DCM (3 × 10 mL) and the organic layer was combined and dried with anhydrous MgSO4, then filtered through a short silica gel eluting with DCM. The filtrate was evaporated under reduced pressure to leave a crude mixture, which was purified through silica gel flash column chromatography eluting with n-hexane to give the final product.

General procedures for cyclopropanation reaction

A screw capped reaction vial was charged with TFHZ-Tfs (0.6 mmol), FeTPPCl (0.009 mmol), then evacuated and filled with argon for three times, then DCM (1.5 mL) which dissolved with styrene (0.3 mmol) and NaOH aq. (5 mL, 20 wt%) was successively added by syringe (Fig. 8). The reaction was stirred at 40 °C for 22 h. Then 10 mL water was added to the mixture and layers partitioned. The aqueous layer was extracted with DCM (3 × 10 mL) and the organic layer was combined and dried with anhydrous MgSO4, then filtered through a short silica gel eluting with DCM. The filtrate was evaporated under reduced pressure to leave a crude mixture, which was purified through silica gel flash column chromatography eluting with n-hexane to give the final cyclopropane product.

Data availability

The authors declare that all the data supporting the findings of this study are available within the paper and its supplementary information files, or from the corresponding author upon request. The X-ray crystallographic coordinates for structures reported in this article have been deposited at the Cambridge Crystallographic Data Center (Trifluoroacetaldehyde N-tfsylhydrazone: CCDC 1814685, Trifluoroacetaldehyde N-tosylhydrazone: CCDC 1814683, Trifluoroacetaldehyde N-nosylhydrazone: CCDC 1827227, 9′: CCDC 1814506, 95′: CCDC 1881268). These data could be obtained free of charge from The Cambridge Crystallographic Data Center via


  1. 1.

    Mertens, L. & Koenigs, R. M. Fluorinated diazoalkanes—a versatile class of reagents for the synthesis of fluorinated compounds. Org. Biomol. Chem. 14, 10547–10556 (2016).

    CAS  Article  Google Scholar 

  2. 2.

    Morandi, B. & Carreira, E. M. Iron-catalyzed cyclopropanation with trifluoroethylamine hydrochloride and olefins in aqueous media: in situ generation of trifluoromethyl diazomethane. Angew. Chem. Int. Ed. 49, 938–941 (2010).

    CAS  Article  Google Scholar 

  3. 3.

    Morandi, B. & Carreira, E. M. Rhodium-catalyzed cyclopropenation of alkynes: synthesis of trifluoromethyl-substituted cyclopropenes. Angew. Chem. Int. Ed. 49, 4294–4296 (2010).

    CAS  Article  Google Scholar 

  4. 4.

    Künzi, S. A., Morandi, B. & Carreira, E. M. Preparation of trifluoromethyl-substituted aziridines with in situ generated CF3CHN2. Org. Lett. 14, 1900–1901 (2012).

    Article  Google Scholar 

  5. 5.

    Li, F., Nie, J., Sun, L., Zheng, Y. & Ma, J. A. Silver-mediated cycloaddition of alkynes with CF3CHN2: highly regioselective synthesis of 3-trifluoromethylpyrazoles. Angew. Chem. Int. Ed. 52, 6255–6258 (2013).

    CAS  Article  Google Scholar 

  6. 6.

    Chen, Z., Zheng, Y. & Ma, J. A. Use of a traceless activating and directing group for the construction of trifluoromethylpyrazoles: one-pot transformation of nitroolefins and trifluorodiazoethane. Angew. Chem. Int. Ed. 56, 4569–4574 (2017).

    CAS  Article  Google Scholar 

  7. 7.

    Luo, H., Wu, G., Zhang, Y. & Wang, J. Silver(I)-Catalyzed N-trifluoroethylation of anilines and o-trifluoroethylation of amides with 2,2,2-trifluorodiazoethane. Angew. Chem. Int. Ed. 54, 14503–14507 (2015).

    CAS  Article  Google Scholar 

  8. 8.

    Hyde, S. et al. Copper-catalyzed insertion into heteroatom-hydrogen bonds with trifluorodiazoalkanes. Angew. Chem. Int. Ed. 55, 3785–3789 (2016).

    CAS  Article  Google Scholar 

  9. 9.

    Liu, C. B. et al. A facile parallel synthesis of trifluoroethyl-substituted alkynes. Angew. Chem. Int. Ed. 51, 6227–6230 (2012).

    CAS  Article  Google Scholar 

  10. 10.

    Arkhipov, A. V., Arkhipov, V. V., Cossy, J., Kovtunenko, V. O. & Mykhailiuk, P. K. Unexpected reactivity of trifluoromethyl diazomethane (CF3CHN2): electrophilicity of the terminal N-atom. Org. Lett. 18, 3406–3409 (2016).

    CAS  Article  Google Scholar 

  11. 11.

    Argintaru, O. A., Ryu, D., Aron, I. & Molander, G. A. Synthesis and applications of alpha-trifluoromethylated alkylboron compounds. Angew. Chem. Int. Ed. 52, 13656–13660 (2013).

    CAS  Article  Google Scholar 

  12. 12.

    Molander, G. A. & Ryu, D. Diastereoselective synthesis of vicinally bis(trifluoromethylated) alkylboron compounds through successive insertions of 2,2,2-trifluorodiazoethane. Angew. Chem. Int. Ed. 53, 14181–14185 (2014).

    CAS  Article  Google Scholar 

  13. 13.

    National Research Council. Prudent Practices in the Laboratory: Handling and Management of Chemical Hazards, Updated Version. (The National Academies Press, Washington, DC, 2011).

  14. 14.

    Gilman, H. & Jones, R. G. 2,2,2-Trifluoroethylamine and 2,2,2-trifluorodiazoethane. J. Am. Chem. Soc. 65, 1458–1460 (1943).

    CAS  Article  Google Scholar 

  15. 15.

    Britton, J. & Jamison, T. F. A unified continuous flow assembly-line synthesis of highly substituted pyrazoles and pyrazolines. Angew. Chem. Int. Ed. 56, 8823–8827 (2017).

    CAS  Article  Google Scholar 

  16. 16.

    Pieber, B. & Kappe, C. O. Generation and synthetic application of trifluoromethyl diazomethane utilizing continuous flow technologies. Org. Lett. 18, 1076–1079 (2016).

    CAS  Article  Google Scholar 

  17. 17.

    Mertens, L., Hock, K. J. & Koenigs, R. M. Fluoroalkyl-substituted diazomethanes and their application in a general synthesis of pyrazoles and pyrazolines. Chem. Eur. J. 22, 9542–9545 (2016).

    CAS  Article  Google Scholar 

  18. 18.

    Barluenga, J. & Valdés, C. Tosylhydrazones: new uses for classic reagents in palladium-catalyzed cross-coupling and metal‐free reactions. Angew. Chem. Int. Ed. 50, 7486–7500 (2011).

    CAS  Article  Google Scholar 

  19. 19.

    Xia, Y. & Wang, J. N-tosylhydrazones: versatile synthons in the construction of cyclic compounds. Chem. Soc. Rev. 46, 2306–2362 (2017).

    CAS  Article  Google Scholar 

  20. 20.

    Zhang, Z. et al. Catalytic asymmetric trifluoromethylthiolation via enantioselective [2,3]-sigmatropic rearrangement of sulfonium ylides. Nat. Chem. 9, 970–976 (2017).

    CAS  Article  Google Scholar 

  21. 21.

    Battilocchio, C. et al. Iterative reactions of transient boronic acids enable sequential C–C bond formation. Nat. Chem. 8, 360–367 (2016).

    CAS  Article  Google Scholar 

  22. 22.

    Barluenga, J., Tomás-Gamasa, M., Aznar, F. & Valdés, C. Metal-free carbon–carbon bond-forming reductive coupling between boronic acids and tosylhydrazones. Nat. Chem. 1, 494–499 (2009).

    CAS  Article  Google Scholar 

  23. 23.

    Lin, G.-q, Lei, X., Liu, P., Xu, Q.-Q. & Dong, C. A complementary approach to 3,5-substituted pyrazoles with tosylhydrazones and terminal alkynes mediated by TfOH. Synlett 23, 2087–2092 (2012).

    Article  Google Scholar 

  24. 24.

    Crespin, L., Biancalana, L., Morack, T., Blakemore, D. C. & Ley, S. V. One-pot acid-catalyzed ring-opening/cyclization/oxidation of aziridines with N-tosylhydrazones: access to 1,2,4-triazines. Org. Lett. 19, 1084–1087 (2017).

    CAS  Article  Google Scholar 

  25. 25.

    Moore, W. R., Schatzman, G. L., Jarvi, E. T., Gross, R. S. & McCarthy, J. R. Terminal difluoro olefin analogs of squalene are time-dependent inhibitors of squalene epoxidase. J. Am. Chem. Soc. 114, 360–361 (1992).

    CAS  Article  Google Scholar 

  26. 26.

    Motherwell, W. B., Tozer, M. J. & Ross, B. C. A convenient method for replacement of the anomeric hydroxy group in carbohydrates by difluoromethyl functionality. J. Chem. Soc. Chem. Commun. 1437–1439 (1989).

  27. 27.

    Gouverneur, V. Fluorine in Pharmaceutical and Medicinal Chemistry: From Biophysical Aspects to Clinical Applications (World Scientific, Singapore, 2012).

  28. 28.

    Burton, D. J., Yang, Z.-Y. & Qiu, W. Fluorinated ylides and related compounds. Chem. Rev. 96, 1641–1716 (1996).

    CAS  Article  Google Scholar 

  29. 29.

    Zhao, Y., Huang, W., Zhu, L. & Hu, J. Difluoromethyl 2-pyridyl sulfone: a new gem-difluoroolefination reagent for aldehydes and ketones. Org. Lett. 12, 1444–1447 (2010).

    CAS  Article  Google Scholar 

  30. 30.

    Zheng, J., Cai, J., Lin, J.-H., Guo, Y. & Xiao, J.-C. Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine. Chem. Commun. 49, 7513–7515 (2013).

    CAS  Article  Google Scholar 

  31. 31.

    Ohashi, M. et al. Palladium-Catalyzed coupling reactions of tetrafluoroethylene with arylzinc compounds. J. Am. Chem. Soc. 133, 3256–3259 (2011).

    CAS  Article  Google Scholar 

  32. 32.

    Hu, M. et al. Copper-Catalyzed gem-difluoroolefination of diazo compounds with TMSCF3 via C–F bond cleavage. J. Am. Chem. Soc. 135, 17302–17305 (2013).

    CAS  Article  Google Scholar 

  33. 33.

    Hu, M., Ni, C., Li, L., Han, Y. & Hu, J. gem-Difluoroolefination of diazo compounds with TMSCF3 or TMSCF2Br: transition-metal-free cross-coupling of two carbene precursors. J. Am. Chem. Soc. 137, 14496–14501 (2015).

    CAS  Article  Google Scholar 

  34. 34.

    Wu, G. et al. Switchable 2,2,2-trifluoroethylation and gem-difluorovinylation of organoboronic acids with 2,2,2-trifluorodiazoethane. Eur. J. Org. Chem. 2014, 4477–4481 (2014).

    CAS  Article  Google Scholar 

  35. 35.

    Piettre, S., De Cock, C., Merenyi, R. & Viehe, H. G. Synthesis of fluorinated vinyl sulfides and selenides. Tetrahedron 43, 4309–4319 (1987).

    CAS  Article  Google Scholar 

  36. 36.

    Andrews, K. G., Faizova, R. & Denton, R. M. A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid. Nat. Commun. 8, 15913 (2017).

    ADS  Article  Google Scholar 

  37. 37.

    Decostanzi, M., Campagne, J. M. & Leclerc, E. Fluorinated enol ethers: their synthesis and reactivity. Org. Biomol. Chem. 13, 7351–7380 (2015).

    CAS  Article  Google Scholar 

  38. 38.

    Zhang, D., Liu, H., Zhu, P., Meng, W. & Huang, Y. One-pot syntheses of N-(α-fluorovinyl)azole derivatives from N-(diphenylmethylene)-2,2,2-trifluoroethanamine. RSC Adv. 6, 73683–73691 (2016).

    CAS  Article  Google Scholar 

  39. 39.

    McCune, C. D. et al. Synthesis and deployment of an elusive fluorovinyl cation equivalent: access to quaternary α-(1′-fluoro)vinyl amino acids as potential PLP enzyme inactivators. J. Am. Chem. Soc. 139, 14077–14089 (2017).

    CAS  Article  Google Scholar 

  40. 40.

    Lu, H. & Zhang, X. P. Catalytic C–H functionalization by metalloporphyrins: recent developments and future directions. Chem. Soc. Rev. 40, 1899–1909 (2011).

    CAS  Article  Google Scholar 

  41. 41.

    Ohashi, M., Adachi, T., Ishida, N., Kikushima, K. & Ogoshi, S. Synthesis and reactivity of fluoroalkyl copper complexes by the oxycupration of tetrafluoroethylene. Angew. Chem. Int. Ed. 56, 11911–11915 (2017).

    CAS  Article  Google Scholar 

  42. 42.

    Kojima, R., Kubota, K. & Ito, H. Stereodivergent hydrodefluorination of gem-difluoroalkenes: selective synthesis of (Z)- and (E)-monofluoroalkenes. Chem. Commun. 53, 10688–10691 (2017).

    CAS  Article  Google Scholar 

  43. 43.

    Moody, J. D., VanDerveer, D., Smith, D. W. Jr & Iacono, S. T. Synthesis of internal fluorinated alkenesvia facile aryloxylation of substituted phenols with aryl trifluorovinyl ethers. Org. Biomol. Chem. 9, 4842–4849 (2011).

    CAS  Article  Google Scholar 

  44. 44.

    Guo, X. & Hu, W. Novel multicomponent reactions via trapping of protic onium ylides with electrophiles. Acc. Chem. Res. 46, 2427–2440 (2013).

    CAS  Article  Google Scholar 

  45. 45.

    Prakash, G. K. et al. Long-lived trifluoromethanide anion: a key intermediate in nucleophilic trifluoromethylations. Angew. Chem. Int. Ed. 53, 11575–11578 (2014).

    CAS  Article  Google Scholar 

  46. 46.

    Lee, K. et al. Catalytic enantioselective addition of organoboron reagents to fluoroketones controlled by electrostatic interactions. Nat. Chem. 8, 768–777 (2016).

    CAS  Article  Google Scholar 

  47. 47.

    Wang, F. et al. Divergent synthesis of CF3 -substituted allenyl nitriles by ligand-controlled radical 1,2- and 1,4-addition to 1,3-enynes. Angew. Chem. Int. Ed. 57, 7140–7145 (2018).

    CAS  Article  Google Scholar 

  48. 48.

    Reggelin, M. in Sulfur-Mediated Rearrangements II (ed. Ernst Schaumann) 1–65 (Springer, Berlin, Heidelberg, 2007).

  49. 49.

    West, T. H., Spoehrle, S. S. M., Kasten, K., Taylor, J. E. & Smith, A. D. Catalytic stereoselective [2,3]-rearrangement reactions. ACS Catal. 5, 7446–7479 (2015).

    CAS  Article  Google Scholar 

  50. 50.

    Hock, K. J., Mertens, L., Hommelsheim, R., Spitzner, R. & Koenigs, R. M. Enabling iron catalyzed Doyle–Kirmse rearrangement reactions with in situ generated diazo compounds. Chem. Commun. 53, 6577–6580 (2017).

    CAS  Article  Google Scholar 

  51. 51.

    Morandi, B., Mariampillai, B. & Carreira, E. M. Enantioselective cobalt-catalyzed preparation of trifluoromethyl-substituted cyclopropanes. Angew. Chem. Int. Ed. 50, 1101–1104 (2011).

    CAS  Article  Google Scholar 

  52. 52.

    Tinoco, A., Steck, V., Tyagi, V. & Fasan, R. Highly diastereo- and enantioselective synthesis of trifluoromethyl-substituted cyclopropanes via myoglobin-catalyzed transfer of trifluoromethylcarbene. J. Am. Chem. Soc. 139, 5293–5296 (2017).

    CAS  Article  Google Scholar 

  53. 53.

    Kotozaki, M., Chanthamath, S., Fujii, T., Shibatomi, K. & Iwasa, S. Highly enantioselective synthesis of trifluoromethyl cyclopropanes by using Ru(ii)–Pheox catalysts. Chem. Commun. 54, 5110–5113 (2018).

    CAS  Article  Google Scholar 

  54. 54.

    Grygorenko, O. O., Artamonov, O. S., Komarov, I. V. & Mykhailiuk, P. K. Trifluoromethyl-substituted cyclopropanes. Tetrahedron 67, 803–823 (2011).

    CAS  Article  Google Scholar 

  55. 55.

    Bos, M., Poisson, T., Pannecoucke, X., Charette, A. B. & Jubault, P. Recent progress toward the synthesis of trifluoromethyl- and difluoromethyl-substituted cyclopropanes. Chem. Eur. J. 23, 4950–4961 (2017).

    CAS  Article  Google Scholar 

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Financial support by NSFC (21871043, 21522202, 21502017) and Department of Science and Technology of Jilin Province (20180101185JC, 20190701012GH). EAA thanks the EPSRC for support (EP/M019195/1).

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X.Z. and Z.L. contributed equally to this work. X.Z., Z.L., X.Y., and Y.D. performed the experiments. M.V. and G.Z. conducted mechanistic studies. E.A.A. participated in the discussion of the research results as well as the revision of the manuscript. X.Z. and X.B. wrote the manuscript.

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Correspondence to Xihe Bi.

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Zhang, X., Liu, Z., Yang, X. et al. Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications. Nat Commun 10, 284 (2019).

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