π-Conjugated polymers are widely used in optoelectronics for fabrication of organic photovoltaic devices, organic light-emitting diodes, organic field effect transistors, and so on. Here we describe the protocol for polycondensation of bifunctional aryl ethers or aryl ammonium salts with aromatic dimetallic compounds through cleavage of inert C–O/C–N bonds. This reaction proceeds smoothly in the presence of commercially available Ni/Pd catalyst under mild conditions, affording the corresponding π-conjugated polymers with high molecular weight. The method is applicable to monomers that are unreactive in other currently employed polymerization procedures, and opens up the possibility of transforming a range of naturally abundant chemicals into useful functional compounds/polymers.
π-Conjugated polymers including poly(arene)s are important materials in the field of optoelectronics, e.g., for fabricating organic photovoltaic devices (OPVs)1,2, organic light-emitting diodes (OLEDs)3, and organic field effect transistors (OFETs)4. Conventionally, these polymers have been synthesized by polycondensation based on transition-metal catalyzed cross-coupling reactions, such as Kumada–Tamao–Corriu coupling5,6, Suzuki–Miyaura coupling6,7, Stille coupling8, and so on9,10. Most existing transition-metal-catalyzed polycondensations affording π-conjugated polymers require dihaloarenes as monomers, although the development of direct C–H arylation polymerization (DArP) has recently greatly expanded the substrate scope11.
On the other hand, aromatic C–O/C–N bonds are ubiquitous in natural products, pharmaceuticals, and functional molecules, and many compounds containing these bonds, such as ethers and anilines, are produced on an industrial scale at reasonable cost. In recent years, synthetic transformations via inert aromatic C–O12,13,14,15,16,17 and/or C–N18 bond cleavage have attracted a great deal of attention, not only as an alternative to the use of reactive aromatic halides, but also as a new methodology for the direct conversion and rapid derivatization of functional molecules containing aromatic C–O/C–N bonds. The first Ni-catalyzed C–O cleavage cross-coupling reaction of aryl methyl ethers with Grignard reagents was reported by Wenkert et al. as early as in 197919,20. However, it was then largely neglected for almost 30 years until Dankwardt significantly extended the substrate scope21. Since then, several groups, including ours, have developed various types of cross-coupling reactions of aryl ethers, including Kumada–Tamao–Corriu type (Mg)22,23,24,25,26,27,28, Suzuki–Miyaura type (B)29,30,31,32,33,34,35, Negishi type (Zn, Al)36,37,38,39, Murahashi type (Li)40,41,42,43, and related C–H44,45,46,47,48,49,50 or C–X (X = B, N, Si, etc.)51,52,53,54,55 bond formation reactions. However, it remains unclear whether such inert ethereal C–O bond cleavage can be extended to synthesize functional polymers.
Herein, we report polycondensation using aromatic ether or ammonium salt as a monomer for the synthesis of various π-conjugated polymers via inert C–O/C–N bond cleavage (Fig. 1).
Polycondensation of organometallic reagent with aryl ether
Considering the high reactivity and wide availability of Grignard reagents, we chose the Kumada–Tamao–Corriu type reaction for the initial test, with Grignard reagent 1a and 2,6-dimethoxynaphthalene 2a as model reactants. The fluorene moiety is an important structural unit in various functional π-conjugated polymers. NiCl2(PCy3)2 (PCy3: tricyclohexylphosphine) was selected as the catalyst, as it is known to be effective for ethereal C–O bond cleavage12,13,14,15,16,17,21,22,23,24,25,26,27,28. Grignard reagent 1a was initially prepared by treating 2,7-dibromo-9,9-dihexylfluorene (0a) with magnesium chips in refluxing THF (tetrahydrofuran) (Method A, Table 1). Gratifyingly, an initial attempt in toluene at 120 °C afforded the desired polycondensation product 3aa with M n (number-average molecular weight) of 5.3 kDa and PDI (polydispersity index) of 1.80. Examination of several solvents showed toluene to be greatly superior to etheric solvents (Entries 1–3). During optimization of the reaction conditions, we found that the quality/purity of 1a critically influenced the yield, reactivity, and behavior of this polycondensation. When 1a freshly prepared according to Method A was quenched with iodine, a mixture of the di- and mono-iodides (9,9-dihexyl-2,7-diiodofluorene and 9,9-dihexyl-2-iodofluorene) was obtained, probably due to partial degradation of the C–Mg moiety by THF at the high reaction temperature. We speculated that mono-Grignard reagents presumably terminate the chain growth and reduce the molecular weight of the products. Thus, we examined preparation methods for 1a. Addition of 0.01 equivalent of 1,2-dibromoethane (as an initiator) to the reaction mixture of 0a and Mg turnings was effective; the formation of 1a was greatly accelerated and was completed within 1 h at room temperature (Method B), resulting in dramatically decreased formation of mono-Grignard by-product and smooth polycondensation to give 3aa (M n = 9.7 kDa) (Entry 4). Lastly, we examined Rieke’s method56 for the preparation of active magnesium (Mg*), which enabled rapid insertion of Mg to the C–Br bond at very low temperature (Method C). Polycondensation using the resultant Grignard reagent 1a proceeded very cleanly to afford high-molecular weight polymer 3aa (M n = 11.6 kDa) (Entry 5). The polymerization temperature also played a key role in determining the yield and M n of this polycondensation (Entries 6 and 7), and a higher molecular weight (M n = 21.1 kDa) of the product 3aa were obtained at room temperature (Entry 7). A higher catalyst loading (10 mol%) did not dramatically change the outcome, while a lower catalyst loading (2.5 mol%) gave 3aa with moderate molecular weight (M n = 7.7 kDa). It is known that lithium salts can formate complexes with several organometallics, such as Grignard reagents, and this can enhance the reactivity in some chemical transformations57,58. However, addition of LiCl to the current reaction system did not change the outcome (LiCl was first added to the THF solution of 1a, which was stored for hours to allow the complexation to occur59).
We next turned our attention to other organometallic species. Recently, Rueping,40 Feringa,41 and our group42–43 have reported protocols for ethereal Murahashi-type coupling using organolithiums, which provide high efficiency under mild conditions. When di-lithium reagent 4a prepared by the bromine-lithium exchange reaction of 0a was employed, the polycondensation with 2a took place smoothly at room temperature with Ni(cod)2 catalyst (cod: 1,5-cyclooctadiene) and SIMes ligand (SIMes: 1,3-bis(2,4,6-trimethylphenyl) imidazolidin-2-ylidene), affording 3aa in 80% yield with high molecular weight (M n = 15.3 kDa, PDI = 1.92) (Table 1, Entry 8). On the other hand, polycondensation of 2a with organoboron reagent29-35 as well as organozincate36 gave unsatisfactory results, yielding low-molecular-weight products (M n < 3.0 kDa) under various conditions. Finally, the set of conditions shown in Entry 7, Table 1 was found to be optimal in terms of efficiency and molecular weight.
Under the optimal conditions, we next examined the scope of the present polycondensation for various aromatic ethers 2, with Grignard reagent 1a/1b. The results are summarized in Fig. 2. We found that 1a freshly prepared from Rieke Mg* and 2a underwent polycondensation smoothly to give the corresponding polymer 3aa with high molecular weight (M n = 23.2 kDa, PDI = 3.02, in 0.3 M solution) in 96% isolated yield. 2,7-Dimethoxynaphthalene 2b and 1,6-dimethoxynaphthalene 2c were also good substrates, and the polycondensations with 1a at room temperature gave 3ab (M n = 23.6 kDa, PDI = 2.73) and 3ac (M n = 13.2 kDa, PDI = 2.53) in 96% and 82% yields, respectively. The reaction of 1,4-dimethoxynaphthalene 2d bearing C–O bonds at the α-position required the use of NHC (N-heterocyclic carbene) ligand (ICy:26,32,35 1,3-bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene) at a higher reaction temperature, giving 3ad in 83% yield (M n = 11.3 kDa, PDI = 2.28). It is known that Ni-catalyzed cross-coupling via inert C–O bond cleavage sometimes suffers from low reactivity toward phenolic substrates12,13,14,15,16,17. Indeed, polycondensation using 1,4-dimethoxybenzene 2e and 1a with Ni(PCy3)2Cl2 catalyst proceeded sluggishly even at higher temperature, affording lower-molecular-weight 3ae (at r.t.: M n = 3.5 kDa, at 70 oC: M n = 4.9 kDa). A big improvement was observed when ICy ligand was used in the polycondensation between 1a and 2e at 70 oC, providing 3ae in 88% yield (M n = 12.1 kDa, PDI = 2.32). NHC ligands have been used for Ni-catalyzed C–O bond cleavage reactions, and show higher activity than PCy3 in some cases, probably because they can stabilize the transition state for oxidative addition of C–O bonds to Ni35. Hence, we think the use of NHC ligand probably accelerated the C–O bond cleavage step, favouring the polycondensation as compared with the decomposition of the Grignard reagent, and thus leading to a greater yield and a higher molecular weight. Other anisole derivatives such as 2f, 2g, and 2h also reacted without difficulty under the same reaction conditions, affording the corresponding polymers 3af–3ah in high yields (M n = 12.7–14.3 kDa, PDI = 2.33–2.56). Further, a chemo-selective polycondensation of 2i was achieved even in the presence of the double bond, giving polymer 3ai with the gem-sp2 linker in 82% yield (M n = 9.2 kDa, PDI = 2.11). Under the current conditions, the reaction of 2,8-dimethoxydibenthiophene was rather sluggish, but 2,8-dimethoxydibenzofuran 2j reacted with 1a without difficulty, and the desired polymer 3aj was obtained in 93% yield (M n = 10.6 kDa, PDI = 2.29). This reaction is not limited to fluorene-tethered Grignard reagent 1a, and a carbazole derivative 1b afforded the corresponding product 3ba in 92% yield (M n = 17.9 kDa, PDI = 2.58). It should be noted that many of these aryl ether monomers, such as 2a-g, are commercially available at reasonable cost (according to SciFinder), while the corresponding di-bromides or di-iodides are either more expensive or less readily accessible. Hence, the current ethereal polycondensation should be a useful supplement to the well-established polymerization protocols based on the use of dihaloarenes.
Axial asymmetric structures are widely utilized in functional molecules, asymmetric synthesis and related areas. For instance, BINOL (2,2ʹ-dihydroxy-1,1ʹ-binaphthyl) derivatives have been extensively used as catalysts or ligands for asymmetric synthesis, and also are important motifs in supramolecular architectures and components of optical materials60. Thus, we examined whether the BINOL unit can be installed in the polymers obtained with the present polycondensation strategy. However, all attempts at preparing the intermediary Grignard reagent having a BINOL skeleton under various conditions were unsuccessful, probably due to low reactivity of the corresponding bromides. On the other hand, di-lithium reagents 4cR or 4cS could be prepared easily via a Li/Br exchange protocol (Supplementary Fig. 1). After extensive experimentation, we found that Murahashi-type polycondensation of 2a with 4c was effective, providing 3ca in high yield (Fig. 3). The ethereal moieties on the BINOL ring remained intact, indicating that the reaction could be used for chemoselective polycondensation of substrates having multiple C–O bonds. Further, no racemization occurred at the axially asymmetric positions (Supplementary Fig. 2). These results demonstrate the potential applicability of this method to generate various axially asymmetric architectures of functional molecules/materials, which may have unusual optical properties.
Polycondensation of grignard reagent with ammonium salt
With the ethereal C–O bond-cleavage polycondensation in hand, we next considered whether the protocol could also be applied to C–N bond cleavage. Amine groups occur in many biologically essential compounds and are widely used in industry for preparation of pharmaceuticals and functional molecules, but the high stability of amino C–N bonds makes them highly resistant to cleavage reactions18. On the other hand, quaternary aryl ammonium salts can be easily prepared from various anilines, and such C–N bonds exhibit higher reactivity than those of amines. Following the pioneering work by Wenkert et al. in 198861, applications of aryl ammonium salts for cross-coupling and related reactions have been rapidly developed in recent years by several groups62,63,64,65,66,67,68,69,70 including ours39,42,69,70. Here, we first tried polycondensation using 1a and 5k or 5 l, with two ammonium moieties (Fig. 4). The reaction proceeded smoothly in THF at room temperature with 1 mol% PdCl2(PPh3)264, giving 3ak and 3al in 95% (M n = 23.4 kDa, PDI = 2.64) and 88% yields (M n = 24.0 kDa, PDI = 2.51), respectively. Interestingly, the reaction of 5k with Grignard reagent 1d having dibenzothiophene was also successful, and 3dk was obtained in 84% yield (M n = 13.5 kDa, PDI = 2.48). (Benzo)thiophene units have been incorporated into many π-conjugated polymers, due to their excellent photoelectrical properties, and the current method provides a route for syntheses of such molecules.
In conclusion, we have developed an effective synthetic method for π-conjugated polymers from various aromatic ethers or ammonium salts through C–O or C–N bond cleavage. With commercially available Ni or Pd catalysts, cross-coupling polycondensation between Grignard reagents/organolithiums and ethers/ammoniums took place smoothly under mild conditions, providing the polycondensation products with high molecular weight in good to excellent yield. The purity of the organometallic coupling partners is important for achieving a smooth reaction. The current results not only provide a methodology for inert C–O/C–N bond cleavage cross-coupling reactions, but also open up a new route for the synthesis of various functional molecules/polymers. Further investigations of the reaction scope (e.g., organoboron, organozinc, and/or other C–O/C–N electrophiles) and synthetic applications of the present method to photoelectrical materials, are in progress. It should be noted that previous mechanistic studies on transition metal-catalyzed C–O/C–N bond cleavage reactions from our group27,35,69 and others35,43,46,47,49 have found that the oxidative addition of ethereal C–O bond to Ni generally suffers from high activation barriers. However, it can be greatly facilitated either by formation of the Ni(0)-ate complex with Grignard reagent or by NHC ligand. On the other hand, due to the high reactivity, C–N bond cleavage in aryl ammonium salts with transition metals is kinetically and thermodynamically favorable, and the subsequent transmetalation becomes rate-determining. In this context, we are conducting a comprehensive mechanistic study of the present polycondensation reactions using both theoretical and experimental methods, aiming to improve the reactivity and selectivity, as well as to provide a sound basis to design and establish new polymerization protocols.
Typical procedure for polycondensation
To a dry Schlenk flask charged with argon, Grignard reagent 1 (0.3 mmol, THF solution) was added. THF was then removed under vacuum at 0 °C, and toluene (1 mL) was added. The mixture was stirred for 5 min and evaporated again under vacuum. Next, dimethoxyarenes 2 (0.3 mmol), Catalyst A [NiCl2(PCy3)2 (5 mol%) and PCy3 (10 mol%)] or B [Ni(cod)2 (5 mol%) and ICy (10 mol%, prepared in situ by treating ICy • HCl with stoichiometric amounts of EtMgBr)] and toluene (1 mL) were added. This reaction mixture was stirred overnight (>12 h) at room temperature or with heating, and then quenched with 1 M HCl (5 mL). The aqueous layer was extracted with CH2Cl2 (3 × 5 mL), and the organic solution was dried over MgSO4, filtered, and concentrated under vacuum. The residue was dissolved in a minimum amount of CH2Cl2 (ca. 1 mL) and precipitated by adding the solution to MeOH (100 mL). The precipitate was collected and dried under vacuum. For full details, see Supplementary Figs. 1–18, Supplementary Tables 1–3 and Supplementary Methods
Detailed experimental procedures and characterization of compounds can be found in the Supplementary Information (Supplementary Figs. 1–18, Supplementary Tables 1–3 and Supplementary Methods). All data are available from the authors on reasonable request.
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This work was supported by JSPS Grant-in-Aid for Scientific Research on Innovative Areas (No. 17H05430) (to M. U.), JSPS KAKENHI (S) (No. 17H06173) (to M. U.), JSPS KAKENHI (C) (No. 18K06544) (to C. W.), and by grants from Kobayashi International Scholarship Foundation (to M. U. and C. W.), and YakuGaku ShinKoKai Foundation (to C. W.). Z.-K.Y. is grateful for the Junior Research Associate fellowship provided by RIKEN and the JSPS Research Fellowships for Young Scientists (DC1) .
The authors declare no competing interests.
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