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Comment on: Platelet-rich plasma intracavernosal injections for the treatment of primary organic erectile dysfunction: a systematic review and meta-analysis of contemporary controlled studies

International Journal of Impotence Research (2024)Cite this article

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We congratulate the authors for their exemplary work in conducting a comprehensive systematic review and meta-analysis regarding the application of intracavernous platelet-rich plasma (PRP) injections in the treatment of erectile dysfunction (ED) [1]. They demonstrated exceptional proficiency through their summarization and insightful discussion of the existing evidence regarding a relatively new therapy, which is still replete with gaps in the literature.

Nevertheless, we would like to draw attention to a specific aspect of their meta-analysis that deserves consideration. In their inclusion criteria, the authors specify the incorporation of studies involving patients utilizing PRP either alone or in combination for the treatment of organic ED [1]. Subsequently, in the statistical pooling comparing PRP to placebo, they encompassed Masterson et al.’s randomized controlled trial (RCT) [2]. They appropriately acknowledge that this trial’s population continued the use of phosphodiesterase type 5 inhibitors (PDE5i) throughout the study and that this could have been a source of heterogeneity when compared with research in which PRP and placebo were administered alone [1].

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References

  1. Panunzio A, Labate C, Zacheo F, Orlando R, Rizzo FL, Porcaro AB, et al. Platelet-rich plasma intracavernosal injections for the treatment of primary organic erectile dysfunction: a systematic review and meta-analysis of contemporary controlled studies. Int J Impot Res. 2023. https://doi.org/10.1038/s41443-023-00798-y

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  2. Masterson TA, Molina M, Ledesma B, Zucker I, Saltzman R, Ibrahim E, et al. Platelet-rich plasma for the treatment of erectile dysfunction: a prospective, randomized, double-blind, placebo-controlled clinical trial. J Urol. 2023;210:154–61.

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  4. Masterson TA, Molina M, Ledesma B, Zucker I, Saltzman R, Ibrahim E, et al. Platelet-rich plasma for the treatment of erectile dysfunction: a prospective, randomized, double-blind, placebo-controlled clinical trial. Reply. J Urol. 2023;210:734–5.

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Authors and Affiliations

  1. Faculty of Medical Sciences, Universidade de Pernambuco, Recife, Brazil

    David Romeiro Victor

  2. Department of Urology, Universidade de São Paulo, São Paulo, Brazil

    Bárbara Vieira Lima Aguiar Melão

Authors
  1. David Romeiro Victor
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  2. Bárbara Vieira Lima Aguiar Melão
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Contributions

Concept and structure: DRV. Drafting of the paper: DRV. Critical revisions and redrafting: BVLAM. Supervision: BVLAM.

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Correspondence to David Romeiro Victor.

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Victor, D.R., Melão, B.V.L.A. Comment on: Platelet-rich plasma intracavernosal injections for the treatment of primary organic erectile dysfunction: a systematic review and meta-analysis of contemporary controlled studies. Int J Impot Res (2024). https://doi.org/10.1038/s41443-024-00850-5

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  • DOI: https://doi.org/10.1038/s41443-024-00850-5

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