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Platelet-rich plasma intracavernosal injections for the treatment of primary organic erectile dysfunction: a systematic review and meta-analysis of contemporary controlled studies

International Journal of Impotence Research (2023)Cite this article

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Abstract

We aim to summarize the latest evidence on platelet-rich plasma (PRP) intracavernosal injections efficacy in men affected by primary organic erectile dysfunction (ED). We reviewed the literature for randomized controlled trials (RCTs) or prospective and retrospective comparative studies evaluating PRP alone or in combination for ED treatment. A comprehensive search in PubMed, Scopus, Web of Science, and ClinicalTrials.gov was performed for English language full-text articles or conference abstracts. A qualitative and quantitative data synthesis was provided. Overall, seven records were included: three RCTs evaluated PRP vs. placebo, one study separately tested PRP and low-intensity shock wave therapy (Li-SWT), three studies compared Li-SWT or low-intensity pulsed ultrasound alone with their combination with PRP. Of 641 included patients, 320 received PRP. Despite the heterogeneity among inclusion criteria, dose and protocol of PRP administration, and outcomes measured, most studies independently reported better sexual outcomes in patients who received PRP, without significant severe side effects. In meta-analysis, where only placebo-controlled studies were included, patients treated with PRP showed higher International Index of Erectile Function (erectile function domain) score compared to patients who received placebo: pooled mean difference (95% Confidence Interval) of 2.99 (1.86, 4.13) after 1 month (209 patients) vs. 2.85 (1.61, 4.09) after 3 months (204 patients) vs. 3.21 (1.82, 4.60) after 6 months (199 patients) of follow-up. In men affected by primary organic ED, PRP intracavernosal injections demonstrated an objective improvement or at least a tendency in erectile function recovery. Patient numbers, and the short-term follow-up may limit the generalizability of these observations. High quality, large-scale, and standardized controlled trials are needed before recommending its definitive use in clinical practice.

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Authors and Affiliations

  1. Department of Urology, “Vito Fazzi” Hospital, Lecce, Italy

    Andrea Panunzio, Connie Labate, Federico Zacheo, Rossella Orlando, Floriana Luigina Rizzo, Vincenzo Pagliarulo & Alessandro Tafuri

  2. Department of Urology, Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy

    Antonio Benito Porcaro & Filippo Migliorini

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  1. Andrea Panunzio
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AT: conceptualization and project administration; AP: methodology and formal analysis; AP, CL, FZ, RO and FLR: data curation; AP and AT: manuscript—original draft; AP, AT and RO.: manuscript—review & editing; ABP, FM, VP and AT; supervisions. All authors have read and approved the final version of this manuscript.

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Panunzio, A., Labate, C., Zacheo, F. et al. Platelet-rich plasma intracavernosal injections for the treatment of primary organic erectile dysfunction: a systematic review and meta-analysis of contemporary controlled studies. Int J Impot Res (2023). https://doi.org/10.1038/s41443-023-00798-y

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