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Clinical relevance of reversible cerebral vasoconstriction syndrome in pregnant women with posterior reversible encephalopathy syndrome: review of case reports in Japan

Hypertension Research volume 47, pages 1288–1297 (2024)Cite this article

Abstract

We systematically reviewed case reports of posterior reversible encephalopathy syndrome (PRES), and investigated the characteristics of PRES in pregnant Japanese women and the clinical relevance of reversible cerebral vasoconstriction syndrome (RCVS) in pregnant women with PRES. Articles were collected using the PubMed/Medline and Ichushi-Web databases. This review was ultimately conducted on 121 articles (162 patients). The clinical characteristics of PRES, individual sites of PRES lesions, edema types, and clinical characteristics of RCVS in PRES cases were examined. The most common individual site of PRES lesion was the occipital lobe (83.3%), followed by the basal ganglia, parietal lobe, frontal lobe, brain stem, cerebellum, temporal lobe, thalamus, and splenium corpus callosum (47.5, 42.6, 24.7, 16.1, 9.3, 5.6, 4.3, and 0.0%, respectively). Edema types in 79 cases with PRES were mainly the vasogenic edema type (91.1%), with very few cases of the cytotoxic edema type (3.8%) and mixed type (5.1%). Among 25 PRES cases with RCVS, RCVS was not strongly suspected in 17 (68.0%) before magnetic resonance angiography. RCVS was observed at the same time as PRES in 13 cases (approximately 50%), and between days 1 and 14 after the onset of PRES in the other 12. These results suggest that the basal ganglia is a frequent site of PRES lesions in pregnant women. RCVS may occur at or after the onset of PRES, even if there are no symptoms to suggest RCVS.

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Acknowledgements

The authors received advice from Dr. Teppei Matsubara, a neurosurgeon, during the preparation of this article.

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Authors and Affiliations

  1. Departments of Obstetrics and Gynecology, Jichi Medical University School of Medicine, 3111-1 Yakushiji, Shimotsuke-shi, Tochigi, 329-0498, Japan

    Hirotada Suzuki, Akihide Ohkuchi, Kenji Horie, Manabu Ogoyama, Rie Usui, Hironori Takahashi & Hiroyuki Fujiwara

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Suzuki, H., Ohkuchi, A., Horie, K. et al. Clinical relevance of reversible cerebral vasoconstriction syndrome in pregnant women with posterior reversible encephalopathy syndrome: review of case reports in Japan. Hypertens Res 47, 1288–1297 (2024). https://doi.org/10.1038/s41440-024-01619-5

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