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Associations between long-term averages of metabolic parameters in adulthood and cardiac structure and function in later life

Hypertension Research volume 47, pages 496–506 (2024)Cite this article

Abstract

The effects of long-term levels of body mass index (BMI), blood pressure (BP), plasma lipids and fasting blood glucose (FBG) on the cardiac structure and function in later life in general population are to evaluate. We included adult participants without heart failure from Framingham Heart Study. The respective averages over a span of 30–36 years of seven parameters were pooled into linear regression models simultaneously to evaluate their associations with subsequent left atrial internal dimension (LAID), left ventricular mass index (LVMi), internal dimension (LVID), ejection fraction (LVEF), global longitudinal strain (GLS) and mitral inflow velocity to early diastolic mitral annular velocity (E/é). In 1838 participants (56.0% female, mean age 66.1 years), per 1-standard deviation (SD) increment of mean BMI correlated with larger LAID and LVID (β 0.05~0.17, standard error [SE] 0.01 for all), greater LVMi (β [SE], 1.49 [0.46]), worse E/é (β [SE], 0.28 [0.05]). Per 1-SD increment of mean systolic BP correlated with greater LVMi (β [SE], 4.70 [0.69]), LVEF (β [SE], 0.73 [0.24]), E/é (β [SE], 0.52 [0.08]), whereas increase of mean diastolic BP correlated with smaller LVMi (β [SE], −1.61 [0.62]), LVEF (β [SE], −0.46 [0.22]), E/é (β [SE], −0.30 [0.07]). Per 1-SD increment of mean high density lipoprotein cholesterol (HDL-c) correlated with smaller LVID (β [SE], −0.03 [0.01]) and better systolic function (LVEF, β [SE], 0.63 [0.19]; GLS, β [SE], −0.20 [0.10]). The variabilities of BMI, BP and HDL-c also correlated with certain cardiac measurements. In long-term, BMI affected the size and mass of heart chambers, systolic and diastolic BP differently influenced left ventricular mass and function, higher HDL-c linked to better systolic function. Clinical trial registration: URL: https://clinicaltrials.gov. Identifier: NCT00005121.

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Acknowledgements

We gratefully acknowledge the participants, investigators, research coordinators and committee members of the Framingham Heart Study.

Funding

This study was funded by the National Natural Science Foundation of China (81800344, 81800345, and 82000372), Guangdong Natural Science Foundation (2022A1515111120, 2020A1515010452, and 2020A1515011095).

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Author notes

  1. These authors contributed equally: Yuzhong Wu, Chen Chen

Authors and Affiliations

  1. Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, P R China

    Yuzhong Wu, Chen Chen, Fang-fei Wei, Weihao Liang, Yugang Dong, Chen Liu, Manting Choy & Bin Dong

  2. NHC Key Laboratory of Assisted Circulation (Sun Yat-sen University), Guangzhou, 510080, P R China

    Yuzhong Wu, Chen Chen, Fang-fei Wei, Weihao Liang, Yugang Dong, Chen Liu, Manting Choy & Bin Dong

  3. National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P R China

    Yugang Dong, Chen Liu & Bin Dong

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Contributions

Under the direction of BD and MC, YW and CC performed the study design, data extraction, and statistical analysis. YW wrote the original draft, while BD and MC revised the draft. All other authors checked the data to ensure accuracy and edited the manuscript prior to submission to ensure the standard English grammar.

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Correspondence to Manting Choy or Bin Dong.

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Wu, Y., Chen, C., Wei, Ff. et al. Associations between long-term averages of metabolic parameters in adulthood and cardiac structure and function in later life. Hypertens Res 47, 496–506 (2024). https://doi.org/10.1038/s41440-023-01475-9

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