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  • Review Article
  • Special Issue: Current evidence and perspectives for hypertension management in Asia
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Obstructive sleep apnea and non-dipper: epiphenomena or risks of Alzheimer’s disease?: a review from the HOPE Asia Network

Hypertension Research volume 47, pages 271–280 (2024)Cite this article

Abstract

Obstructive sleep apnea (OSA) and associated nocturnal blood pressure (BP) surges is associated with non-dipper. On the other hand, the relationship between neurodegenerative diseases and non-dipper hypertension has been reported. To date, few studies have evaluated the relationships of nocturnal BP dipping patterns and OSA in relation to neurodegenerative diseases, particularly Alzheimer’s disease (AD). This review examines the etiology of the association between OSA and the non-dipper pattern of hypertension and how both are involved in the development of AD. To set the stage for this review, we first focus on the pathophysiology of AD, which is interrelated with sleep apnea and non-dipper through dysregulation of central autonomic network.

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Acknowledgements

The authors thank Viatris for the grant to support the HOPE Asia Network activities.

the HOPE Asia Network

Michiaki Nagai1,2 Keigo Dote2 Sungha Park3 Yuda Turana4 Peera Buranakitjaroen5 Hao-Min Cheng6,7,8,9 Arieska Ann Soenarta10 Yan Li11 Kazuomi Kario12

Author information

Authors and Affiliations

  1. Cardiovascular Section, Department of Internal Medicine, Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Michiaki Nagai

  2. Department of Cardiology, Hiroshima City Asa Hospital, Hiroshima, Japan

    Michiaki Nagai & Keigo Dote

  3. Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea

    Sungha Park

  4. Department of Neurology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

    Yuda Turana

  5. Division of Hypertension, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Peera Buranakitjaroen

  6. Institute of Public Health and Community Medicine Research Center, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan

    Hao-Min Cheng

  7. Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

    Hao-Min Cheng

  8. Ph.D. Program of Interdisciplinary Medicine (PIM), National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan

    Hao-Min Cheng

  9. Department of Medical Education, Center for Evidence-Based Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

    Hao-Min Cheng

  10. Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia

    Arieska Ann Soenarta

  11. Department of Cardiovascular Medicine, Shanghai Institute of Hypertension Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

    Yan Li

  12. Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan

    Kazuomi Kario

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on behalf of the HOPE Asia Network

  • Michiaki Nagai
  • , Sungha Park
  • , Yuda Turana
  • , Peera Buranakitjaroen
  • , Hao-Min Cheng
  • , Arieska Ann Soenarta
  •  & Yan Li

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Correspondence to Michiaki Nagai.

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Conflict of interest

SP received honoraria from Pfizer, Boryoung, Hanmi, Daewoong, Donga, Celltrion, Servier, Daiichi Sankyo and Daewon. SP also received research grant from Daiichi Sankyo. HMC served as a speaker or member of speakers bureau AstraZeneca; Pfizer Inc.; Bayer AG; Boehringer Ingelheim Pharmaceuticals, Inc.; Daiichi Sankyo, Novartis Pharmaceuticals, Inc.; SERVIER; Co., Pharmaceuticals Corporation; Sanofi; TAKEDA Pharmaceuticals International; Eli Lilly. HMC also received grants for clinical research from: Microlife Co., Ltd. KK reports research grant from A&D, Omron Healthcare, Fukuda Denshi. All other authors declare no conflict of interest.

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Nagai, M., Dote, K., Park, S. et al. Obstructive sleep apnea and non-dipper: epiphenomena or risks of Alzheimer’s disease?: a review from the HOPE Asia Network. Hypertens Res 47, 271–280 (2024). https://doi.org/10.1038/s41440-023-01440-6

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