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  • Special Issue: Current evidence and perspectives for hypertension management in Asia
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Serum triglyceride levels and incidence of hypertension in a general Japanese population: ISSA-CKD study

Hypertension Research volume 46, pages 1122–1131 (2023)Cite this article

Abstract

The aim of this study was to clarify the relationship between fasting and nonfasting serum triglyceride (TG) levels and the incidence of hypertension in a general Japanese population. We conducted a population-based retrospective cohort study using annual health check-up data of residents of Iki City, Nagasaki Prefecture, Japan. A total of 3202 participants without hypertension at baseline were included in the present analysis. TG levels were classified as quartile 1 (<0.82 mmol/L), quartile 2 (0.83–1.13 mmol/L), quartile 3 (1.14–1.70 mmol/L) and quartile 4 (≥1.71 mmol/L) for men, and as quartile 1 (<0.70 mmol/L), quartile 2 (0.71–0.96 mmol/L), quartile 3 (0.97–1.34 mmol/L) and quartile 4 (≥1.35 mmol/L) for women. The outcome was incident hypertension. During an average follow-up of 4.4 years, 983 participants developed hypertension, according to the Cox proportional hazards model. The annual incidence of hypertension increased with an elevation in TG levels for men (5.88% in quartile 1, 8.30% in quartile 2, 7.62% in quartile 3, and 9.82% in quartile 4). This association was significant, even after adjustment for other risk factors: hazard ratio 1.41 [95% CI 1.07–1.85] for quartile 2, 1.30 [0.99–1.71] for quartile 3, and 1.59 [1.22–2.08] for quartile 4 compared with quartile 1 (p = 0.041 for trend). In contrast, there was no clear association between serum TG levels and the incidence of hypertension after adjustment for confounding factors among women (p = 0.240 for trend). High levels of serum TG were associated with the future incidence of hypertension in a general population of Japanese men but were not associated with that in women.

Casual serum triglyceride levels and incidence of hypertension in a general Japanese population: ISSA-CKD study

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Funding

This study was supported by research grants from Iki City. HA received funding from a commercial source, Daiichi Sankyo and Kyowa Kirin. This does not alter our adherence to Hypertension Research policies on sharing data and materials.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

    Shintaro Ishida & Seiji Kondo

  2. Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

    Shunsuke Funakoshi, Makiko Abe, Atsushi Satoh, Miki Kawazoe, Toshiki Maeda, Chikara Yoshimura & Hisatomi Arima

  3. Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

    Yoshihiro Nishida, Kazuhiro Tada, Koji Takahashi, Kenji Ito, Tetsuhiko Yasuno & Kosuke Masutani

  4. Department of Endocrinology and Diabetes Mellitus, Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

    Daiji Kawanami

  5. Department of Cardiology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

    Shin-ichiro Miura & Keijiro Saku

  6. Department of Regenerative Medicine and Transplantation, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

    Shohta Kodama

  7. Nagasaki Prefecture Iki Hospital, Nagasaki, Japan

    Shigeaki Mukobara

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  1. Shintaro Ishida
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Correspondence to Hisatomi Arima.

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Ishida, S., Kondo, S., Funakoshi, S. et al. Serum triglyceride levels and incidence of hypertension in a general Japanese population: ISSA-CKD study. Hypertens Res 46, 1122–1131 (2023). https://doi.org/10.1038/s41440-023-01175-4

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