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A SAGE score cutoff that predicts high-pulse wave velocity as measured by oscillometric devices in Brazilian hypertensive patients

Hypertension Research volume 45, pages 315–323 (2022)Cite this article

Abstract

We aimed to identify the optimal cutoff SAGE score for Brazilian hypertensive patients who had their pulse wave velocity (PWV) measured with oscillometric devices. A retrospective analysis of patients who underwent central blood pressure measurement using a validated oscillometric device, the Mobil-O-Graph® (IEM, Stolberg, Germany), between 2012 and 2019 was performed. Patients with arterial hypertension and available data on all SAGE parameters were selected. An ROC curve was constructed using the Youden index to define the best score to identify patients at high risk for high PWV. A total of 837 patients met the criteria for SAGE and diagnosis of hypertension. The median age was 59.0 years (interquartile range [IQR]: 47.0–68.0), and 50.7% of the patients were women. The following comorbidities and conditions were present: dyslipidemia (37.4%), diabetes (20.7%), a body mass index score ≥30 kg/m2 (36.6%), use of antihypertensive drugs (69.5%), and smoking (18.3%). The median peripheral blood pressure was 128 mmHg (IQR: 117–138 mmHg) for systolic and 81 mmHg (IQR: 73–90 mmHg) for diastolic blood pressure. The median PWV was 8.3 m/s (7.1–9.8 m/s), and the prevalence of high PWV (≥10 m/s) was 22.9% (192 patients). A cutoff SAGE score ≥8 was effective at identifying a high risk of PWV ≥ 10 m/s, achieving 67.19% sensitivity (95% CI: 60.1–73.8) and 93.95% specificity (95% CI: 91.8–95.7). With this cutoff point, 1 out of every 5 treated hypertensive patients would be referred for a PWV measurement. A SAGE score of ≥8 identified Brazilian hypertensive patients with a high risk of future cardiovascular events (PWV ≥ 10 m/s).

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Authors and Affiliations

  1. Hypertension League and Postgraduate Program, Medical School—Federal University of Goiás-Brazil, Goiânia, Brazil

    Adriana Camargo Oliveira, Weimar Kunz Sebba Barroso, Ana Luiza Lima Sousa, Rayne Ramos Fagundes & Gilberto Campos Guimarães

  2. Pontifical Catholic University of Goias—Brazil, Goiânia, Brazil

    Priscila Valverde de Oliveira Vitorino & Gilcimar Divino de Deus

  3. Hypertension League of Porto Alegre—Brazil, Porto Alegre, Brazil

    Eduardo Barbosa

  4. Hypertension and Cardiometabolic Syndrome Unit, 1st Department of Cardiology, Medical School, National & Kapodistrian University of Athens, Hippokration Hospital, Athens, Greece

    Panagiotis Xaplanteris & Charalambos Vlachopoulos

  5. Cardiology Department, CHU Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium

    Panagiotis Xaplanteris

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  1. Adriana Camargo Oliveira
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Oliveira, A.C., Barroso, W.K.S., de Oliveira Vitorino, P.V. et al. A SAGE score cutoff that predicts high-pulse wave velocity as measured by oscillometric devices in Brazilian hypertensive patients. Hypertens Res 45, 315–323 (2022). https://doi.org/10.1038/s41440-021-00793-0

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