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Review Series - Recent Advances in the Management of Secondary Hypertension

Recent advances in the management of secondary hypertension: chronic kidney disease

Hypertension Research volume 43, pages 869–875 (2020)Cite this article

Abstract

Hypertension in chronic kidney disease (CKD) is the most commonly observed comorbidity and is a risk factor for end-stage renal disease (ESRD) as well as cardiovascular disease (CVD) and mortality. Therefore, suitable blood pressure (BP) control in CKD patients is very important in preventing both CVD and ESRD. We herein describe the recommendations of target BP and the pharmacological drug options from the evidence-based clinical practice guidelines for CKD in 2018 by the Japanese Society of Nephrology (JSN CKD 2018) and recent advances in the management of hypertension in CKD, including sodium-glucose cotransporter (SGLT) 2 inhibitors, mineralocorticoid receptor blockers, and renal denervation. In particular, SGLT2 inhibitors are a new class of “antihypertensive drugs” that have a homeostatic mechanism that regulates body fluid volume in addition to diuretic action, which may be closely associated with their cardiorenal protective properties.

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Acknowledgements

We thank Keiko Fukuda and Minami Watanabe for their valuable technical support.

Funding

This study was supported in part by a Grant-in-Aid for Young Scientists 15K21321 (to TM), Jichi Medical University Young Investigator Awards (to TM), and a Grant-in-Aid for Research on Advanced Chronic Kidney Disease, Practical Research Project for Renal Diseases from the Japan Agency for Medical Research and Development (AMED to DN).

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  1. Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan

    Takahiro Masuda & Daisuke Nagata

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  1. Takahiro Masuda
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Correspondence to Takahiro Masuda.

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Masuda, T., Nagata, D. Recent advances in the management of secondary hypertension: chronic kidney disease. Hypertens Res 43, 869–875 (2020). https://doi.org/10.1038/s41440-020-0491-4

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