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Antibacterial p-terphenyl and α‑pyrone derivates isolated from the marine-derived actinomycete Nocardiopsis sp. HDN154086

The Journal of Antibiotics volume 77, pages 201–205 (2024)Cite this article

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Abstract

Assisted by OSMAC strategy, one new p-terphenyl and two new α‑pyrone derivates, namely nocarterphenyl I (1) and nocardiopyrone D–E (2–3), were obtained and characterized from the marine sediment-derived actinomycete Nocardiopsis sp. HDN154086. The structures of these compounds were determined on the basis of MS, NMR spectroscopic data and single-crystal X-ray diffraction. Compound 1 with a rare 2,2’-bithiazole structure among natural products showed promising activity against five bacteria with MIC values ranging from 0.8 to 1.6 μM and 3 exhibited notable antibacterial activity against MRSA compared the positive control ciprofloxacin.

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CCDC 2120740 (for 1) contain the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/data_request/cif, or by emailing data_request@ccdc.cam.ac.uk, or by contacting The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB21EZ, UK; fax: +44 1223 336033.

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Funding

This work was supported by the National Key Research and Development Program of China (2022YFC2804400), the Fundamental Research Funds for the Central Universities (202172002), the Shandong Provincial Natural Science Foundation (ZR2021MH257), the National Natural Science Foundation of China (41976105), and the NSFC-Shandong Joint Fund (U1906212).

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Author notes

  1. These authors contributed equally: Luning Zhou, Yimin Chang

Authors and Affiliations

  1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, PR China

    Luning Zhou, Yimin Chang, Shengkuan Yang, Xiaofei Huang, Jiaxiang Wang, Tianjiao Zhu, Dehai Li & Qian Che

  2. Marine Biomedical Research Institute of Qingdao, Qingdao, 266237, PR China

    Chengyu Jiang

  3. Laboratory for Marine Drugs and Bioproducts of Qingdao Pilot National Laboratory for Marine Science and Technology, Qingdao, 266237, PR China

    Tianjiao Zhu, Dehai Li & Qian Che

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  1. Luning Zhou
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Correspondence to Dehai Li or Qian Che.

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41429_2023_698_MOESM1_ESM.doc

Antibacterial p-Terphenyl and α‑Pyrone Derivates Isolated from the Marine-Derived Actinomycete Nocardiopsis sp. HDN154086

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Zhou, L., Chang, Y., Yang, S. et al. Antibacterial p-terphenyl and α‑pyrone derivates isolated from the marine-derived actinomycete Nocardiopsis sp. HDN154086. J Antibiot 77, 201–205 (2024). https://doi.org/10.1038/s41429-023-00698-9

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