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1-(6-Methylsalicyloyl)glycerol from stony coral-derived Micromonospora sp.

The Journal of Antibiotics volume 76, pages 83–87 (2023)Cite this article

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Abstract

A new natural product, 1-(6-methylsalicyloyl)glycerol (1) was isolated from the culture extract of the stony coral-derived Micromonospora sp. C029. The structure of 1 was determined by extensive analysis of 1D and 2D NMR spectroscopic data. The absolute configuration was determined to be S by comparison of specific rotation with synthetic (R)- and (S)-1. Compound 1 showed weak antimicrobial activity against Kocuria rizhophila. Structurally related benzoyl glycerol is not reported from actinomycetes, suggesting that isolation of actinomycetes from little studied environments should be important for the discovery of novel natural products.

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Acknowledgements

P388 cells were obtained from JCRB Cell Bank under accession code JCRB0017 (Lot. 06252002).

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Authors and Affiliations

  1. Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan

    Enjuro Harunari, Haruka Doyo & Yasuhiro Igarashi

  2. Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand

    Wongsakorn Phongsopitanun & Somboon Tanasupawat

  3. Department of Biology, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand

    Makamas Sutthacheep & Thamasak Yeemin

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  1. Enjuro Harunari
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Correspondence to Yasuhiro Igarashi.

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Harunari, E., Doyo, H., Phongsopitanun, W. et al. 1-(6-Methylsalicyloyl)glycerol from stony coral-derived Micromonospora sp.. J Antibiot 76, 83–87 (2023). https://doi.org/10.1038/s41429-022-00578-8

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