Comment | Published:

MK2 puts an additional brake on RIPK1 cytotoxic potential

Cell Death & Differentiationvolume 25pages457459 (2018) | Download Citation

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Additional information

Edited by G. Melino


  1. 1.

    Linkermann A, Green DR. Necroptosis. N. Eng. J. Med. 2014;370:455–65.

  2. 2.

    Dondelinger Y, et al. RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition. Cell Death Differ. 2013;20:1381–92.

  3. 3.

    Silke J, et al. The diverse role of RIP kinases in necroptosis and inflammation. Nat Immunol. 2015;16:689–97.

  4. 4.

    Menon MB, et al. p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection. Nat Cell Biol. 2017;19:1248–59.

  5. 5.

    Jaco I, et al. MK2 phosphorylates RIPK1 to prevent TNF-induced cell death. Mol Cell. 2017;66:698–710. e695.

  6. 6.

    Dondelinger Y, et al. MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death. Nat Cell Biol. 2017;19:1237–47.

  7. 7.

    Ting AT, Bertrand MJ. More to life than NF-κB in TNFR1 signaling. Trends Immunol. 2016;37:535–45.

  8. 8.

    Dondelinger Y, et al. NF-κB-independent role of IKKα/IKKβ in preventing RIPK1 kinase-dependent apoptotic and necroptotic cell death during TNF signaling. Mol Cell. 2015;60:63–76.

  9. 9.

    Vlantis K, et al. NEMO prevents RIP Kinase 1-mediated epithelial cell death and chronic intestinal inflammation by NF-κB-dependent and -independent functions. Immunity. 2016;44:553–67.

  10. 10.

    Koppe C, et al. IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1. Hepatology. 2016;64:1217–31.

  11. 11.

    Mohideen F, et al. Quantitative phospho-proteomic analysis of TNFα/NFκB signaling reveals a role for RIPK1 phosphorylation in suppressing necrotic cell death. Mol Cell Proteomics. 2017;16:1200–16.

  12. 12.

    Geng J, et al. Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis. Nat Commun. 2017;8:359.

  13. 13.

    Peterson LW, et al. RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense. J Exp Med. 2017;214:3171–3182.

  14. 14.

    Croft M, Siegel RM. Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases. Nat Rev Rheumatol. 2017;13:217–33.

  15. 15.

    Kawashima R, et al. Interleukin-13 damages intestinal mucosa via TWEAK and Fn14 in mice-a pathway associated with ulcerative colitis. Gastroenterology. 2011;141:2119–29. e2118.

Download references

Author information


  1. VIB Center for Inflammation Research, Technologiepark 927, 9052, Zwijnaarde-Ghent, Belgium

    • Yves Dondelinger
    • , Tom Delanghe
    •  & Mathieu M. J. Bertrand
  2. Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052, Zwijnaarde-Ghent, Belgium

    • Yves Dondelinger
    • , Tom Delanghe
    •  & Mathieu M. J. Bertrand


  1. Search for Yves Dondelinger in:

  2. Search for Tom Delanghe in:

  3. Search for Mathieu M. J. Bertrand in:

Conflict of interest

The authors declare that they have no competing interests.

Corresponding author

Correspondence to Mathieu M. J. Bertrand.

About this article

Publication history