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MicroRNA-200 family expression analysis in metastatic clear cell renal cell carcinoma patients

Cancer Gene Therapy volume 27, pages 768–772 (2020)Cite this article

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Abstract

The aim of this study is to analyse the of expression levels of microRNA-200 family members in patients with metastatic clear cell renal cell carcinoma (ccRCC). Analysis of microRNA expression was performed on 23 paired DNA samples extracted from kidney tumour tissue and the surrounding normal renal parenchyma. MicroRna-200c was found to have significantly lower expression (in kidney tumour tissue compared to normal renal parenchyma. No other microRna-200 family members showed statistically significant differences in expression levels between tumour and normal kidney tissue. Recent data suggest that the role of microRNA-200c in tumour pathogenesis is rather contradictory, and the underlying mechanisms by which microRNA-200c affects the carcinogenic potential of malignant cells remains unclear and requires further investigation at the molecular level.

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Acknowledgements

This study was performed using equipment from Biomika Shared Access Center and the unique KODINK research facility, DNA samples from Shared Access Center “Collection of Human Biologic Materials” (Institute of Biochemistry and Genetics UFRS RAS). This work was supported by the Russian Foundation for Basic Research grant (project no. 17-44-020050).

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Authors and Affiliations

  1. Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences, Ufa, Russian Federation

    Irina R. Gilyazova, Elizaveta A. Klimentova, Marina A. Bermisheva & Elsa K. Khusnutdinova

  2. Bashkir State Medical University, Ufa, Russian Federation

    Irina R. Gilyazova, Adel A. Izmailov, Elmira F. Galimova, Ruslan I. Safiullin, Shamil N. Galimov, Valentin N. Pavlov & Elsa K. Khusnutdinova

  3. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation

    Kirill V. Bulygin

  4. M.V. Lomonosov Moscow State University, Moscow, Russian Federation

    Kirill V. Bulygin

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  1. Irina R. Gilyazova
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  2. Elizaveta A. Klimentova
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Correspondence to Kirill V. Bulygin.

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Gilyazova, I.R., Klimentova, E.A., Bulygin, K.V. et al. MicroRNA-200 family expression analysis in metastatic clear cell renal cell carcinoma patients. Cancer Gene Ther 27, 768–772 (2020). https://doi.org/10.1038/s41417-019-0149-z

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