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Clinical characteristics and prognostic analysis of multiple primary malignant neoplasms in patients with lung cancer

Cancer Gene Therapy volume 26, pages 419–426 (2019)Cite this article

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Abstract

Retrospective analysis of data from 14,528 lung cancer patients with multiple primary malignant neoplasm (MPMN) revealed that 2.5% (364/14,528) were MPMN cases and 96.2% (350/364) were diagnosed with two primary malignancies, 3.6% (13/364) with three primary malignancies, and 0.3% (1/364) with four primary malignancies. Among 350 lung cancer patients diagnosed with two primary malignancies, 26.6% (93/350) had lung cancer diagnosed first (LCF) and 73.4% (257/350) had other cancers diagnosed initially (OCF), whereas synchronous MPMN (SMPMN) accounted for 21.1% (74/350) and metachronous MPMN (MMPMN) accounted for 78.9% (276/350) of the cases. Detection of first primary neoplasms were at an early stage for LCF patients and the age of the first lung cancer diagnosis was 59.3 years vs. 55.4 years in the OCF group (P = 0.008), whereas the onset age of second primary neoplasm diagnosis was similar in both groups (62.5 and 61.6 years, P = 0.544). Median survival times of MMPMN and SMPMN patients in the LCF group were 6.83 and 2.42 years and in the OCF group 8.67 years and 2.25 years, respectively. Multivariate analysis showed that SMPMN, LCF and the age of the primary cancer diagnosed first ( ≥ 60 years) and NSCL staging  > II were significant independent factors for inferior prognosis of patients.

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Funding

This work was supported by Establishment of Lung Cancer Database in Henan.

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Authors and Affiliations

  1. Department of Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, 450008, Zhengzhou, China

    Huijuan Wang, Guowei Zhang, Mina Zhang, Peng Li, Xiangtao Yan & Zhiyong Ma

  2. Department of Oncology, The Second People’s Hospital of Jiaozuo, 454000, Jiaozuo, China

    Jingjing Hou

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Contributions

HW, JH, and ZM were responsible for the conception and design of the study. JH, GZ, MZ, PL, and XY were responsible for acquisition and analysis of data; furthermore, JH, MZ, and XY were in charge of statistical analysis. HW, HJ, GZ, and ZM drafted the manuscript; HW and ZM revised and commented the draft, and HW, MZ, and ZM approved the final version of the manuscript.

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Correspondence to Zhiyong Ma.

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The authors declare that they have no conflict of interest.

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Consent for publication was obtained from all patients.

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The ethical committee of the Henan Cancer Hospital approved this study and written informed consent was obtained from all patients.

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Supplementary information

41417_2019_84_MOESM1_ESM.docx

Supplementary Table 1. Distribution of concomitant malignancies in 350 MPMN patients with lung cancer (number of cases %)

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Wang, H., Hou, J., Zhang, G. et al. Clinical characteristics and prognostic analysis of multiple primary malignant neoplasms in patients with lung cancer. Cancer Gene Ther 26, 419–426 (2019). https://doi.org/10.1038/s41417-019-0084-z

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