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To D or not to D: vitamin D in hematopoietic cell transplantation

Bone Marrow Transplantation volume 55, pages 2060–2070 (2020)Cite this article

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Abstract

Vitamin D plays an essential role in bone health, immune tolerance, and immune modulation. Autologous and allogeneic hematopoietic cell transplantation (HCT) recipients are at increased risk of vitamin D deficiency, which may increase risks of bone loss and fracture, graft-versus-host disease (GVHD), and relapse, and can delay hematologic and immune recovery following HCT. Growing evidence indicates that vitamin D may have a role as an immunomodulator, and supplementation during HCT may decrease the risk of GVHD, infection, relapse, and mortality. In this paper, we review the role of vitamin D and its association with HCT outcomes and discuss prevention and treatment of vitamin D deficiency after HCT in adult recipients. We review the role of monitoring of vitamin D levels pre- and post-HCT and its supplementation in appropriate patients. We also review the use of bone densitometry prior to HCT and in long-term follow-up and the treatment of osteoporosis in this high-risk population.

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Acknowledgements

The authors would like to acknowledge and thank Stephanie J. Lee for reviewing the paper and providing comments.

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  1. Blood and Marrow Transplant Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA

    Sanghee Hong, Christina S. Ferraro, Betty K. Hamilton & Navneet S. Majhail

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  3. Betty K. Hamilton
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Correspondence to Navneet S. Majhail.

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None of the authors has a financial conflict of interest to disclose in relation to this study. NSM is partially supported by a grant from the National Cancer Institute (R01-CA215134). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Hong, S., Ferraro, C.S., Hamilton, B.K. et al. To D or not to D: vitamin D in hematopoietic cell transplantation. Bone Marrow Transplant 55, 2060–2070 (2020). https://doi.org/10.1038/s41409-020-0904-7

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