The Multiple Sclerosis Intimacy and Sexuality Questionnaire (MSISQ-15): validation of the Italian version for individuals with spinal cord injury


Study design

Psychometric study.


The aim of the study was to translate and culturally adapt the MSISQ-15 into Italian and to administer it to individuals with a spinal cord injury (SCI).


Rome’s Wheelchair Rugby Team and three spinal units in Italy.


Translation and validation of the MSISQ-15 were performed based on international guidelines. The questionnaire, which was in a paper and online format, was administered with the Short Form-12 Health Survey (SF-12) and the Spinal Cord Independence Measure Self-Report.


Sixty-five participants were recruited. Internal consistency coefficient of MSISQ-15 scale, assessed by Cronbach’s alpha, was 0.75. Test–retest reliability interclass correlations was, for example, 0.86. The construct validity was calculated and showed statistically significant results in relation to the mental health status investigated with the SF-12.


The MSISQ-15 is a valid, reliable, and useful questionnaire for investigating how often the symptoms of an SCI interfere with a person’s satisfaction or sexual activity.

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Data availability

The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.


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We acknowledge those who participated in the surveys; their collective expertise greatly informed the development of the Italian version of the MSISQ-15.

Author information




AB, GG, MAM: conceived and/or designed the work that led to the submission, acquired data, and/or played an important role in interpreting the results. MM, MT: drafted or revised the manuscript. DV: approved the final version.

Corresponding author

Correspondence to Giovanni Galeoto.

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The authors declare that they have no conflict of interest.

Ethical approval

The authors certify that all applicable institutional and governmental regulations concerning the ethical use of human volunteers were followed during the course of this research. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent was obtained from all participants for being included in the study. Institutional Review Board approval was not required because the administration of these tool was part of the usual process of assessment of these individuals in clinical practice, the research involved the analysis of data collected such that individual subjects cannot be identified in any way.

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Monti, M., Marquez, M.A., Berardi, A. et al. The Multiple Sclerosis Intimacy and Sexuality Questionnaire (MSISQ-15): validation of the Italian version for individuals with spinal cord injury. Spinal Cord (2020).

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