Abstract
Background
Effective communication of treatment side effects (SE) is critical for shared decision-making (SDM) in localized prostate cancer. We sought to qualitatively characterize how physicians communicate SE in consultations.
Methods
We transcribed 50 initial prostate cancer treatment consultations across nine multidisciplinary providers (Urologists, Radiation Oncologists, Medical Oncologists) at our tertiary referral, academic center. Coders identified quotes describing SE and used an inductive approach to establish a hierarchy for granularity of communication: (1) not mentioned, (2) name only, (3) generalization(“high”), (4) average incidence without timepoint, (5) average incidence with timepoint, and (6) precision estimate. We reported the most granular mode of communication for each SE throughout the consultation overall and across specialty and tumor risk.
Results
Among consultations discussing surgery (n = 40), erectile dysfunction (ED) and urinary incontinence (UI) were omitted in 15% and 12%, not quantified (name only or generalization) in 47% and 30%, and noted as average incidence without timeline in 8% and 8%, respectively. In only 30% and 49% were ED and UI quantified with timeline (average incidence with timeline or precision estimate), respectively. Among consultations discussing radiation (n = 36), irritative urinary symptoms, ED, and other post-radiotherapy SE were omitted in 22%, 42%, and 64–67%, not quantified in 61%, 33%, and 23–28%, and noted as average incidence without timeline in 8%, 22%, and 6–8%, respectively. In only 3–8% were post-radiotherapy SE quantified with timeline. Specialty concordance (but not tumor risk) was associated with higher granularity of communication, though physicians frequently failed to quantify specialty-concordant SE.
Conclusions
SE was often omitted, not quantified, and/or lacked a timeline in treatment consultations in our sample. Physicians should articulate, quantify, and assign a timeline for SE to optimize SDM.
Similar content being viewed by others
Introduction
Shared decision making (SDM)—the guidelines-endorsed standard of care for counseling men with prostate cancer [1]—involves education of patients regarding risks and rewards of therapy and reaching a collaborative treatment decision based on patient preferences for balancing these tradeoffs [2, 3]. Key to this process is clear communication of treatment-related side effects (SE). Both describing and quantifying major SE are critical for the patient to weigh the potential risks of treatment against its rewards (namely, reduction in risk of cancer progression and mortality) [4]. Since patients often have little insight into these tradeoffs [5], it is challenging for the physician to educate the patient in a brief period of time to ensure informed SDM.
Despite the key role of adequate communication of SE in SDM, little is known about how SE are communicated in practice. We previously analyzed variation in communication of the survival benefit related to treatment—the “rewards” side of treatment tradeoffs—during treatment consultations and found substantial variation in the quality of risk communication [6]. In 40 consultations, physicians often failed to communicate the reduction in cancer mortality associated with treatment; cancer mortality was reported without treatment in 38%, with treatment in 10%, and in only 29% of consultations was cancer mortality reported both with and without treatment [6]. To our knowledge, there has been no similar analysis of how treatment-related SE are communicated by counseling physicians.
In this study, we conducted a qualitative analysis of initial treatment consultations of men with newly diagnosed prostate cancer at our institution across 9 multidisciplinary providers who typically counsel these men. We sought to qualitatively characterize how physicians communicate SE and to establish a framework for quality of risk communication. We then sought to better understand how tumor risk and physician specialty affect quality of risk communication regarding SE. We hypothesized that wide variation would exist in whether individual SE were discussed or quantified during the consultation and that this variation would persist in subgroups of specialty and tumor risk. By categorizing how physicians communicate these risks, we aimed to characterize the varying informational quality in reporting risk of SE and gain insight into best practices to optimize SDM.
Materials and methods
Study cohort
We recruited men with newly diagnosed Gleason ≤ 7, clinical stage ≤ T2c prostate cancer undergoing initial outpatient consultations among the practices of three urologists, three medical oncologists, and three radiation oncologists within our institution, a tertiary referral center. We excluded patients <18 years and non-English speakers. The study was IRB approved (Pro#00053972).
Informed consent
Subjects and physicians were informed in the written consent that the study would assess “communication of risks” since more specific disclosure may have influenced content discussed. At the study conclusion, we debriefed subjects about the specific hypothesis. This IRB-approved approach was justified under 45CFR46.116(d).
Consultation coding
Outpatient consultations were digitally recorded and transcribed verbatim. Quotes related to treatment-related SE were extracted from transcripts. Four coders independently analyzed these quotes using an inductive coding approach to characterize SE type, mode of communication, and whether a timeline was mentioned. Our coding approach was informed by our expertise in prostate cancer treatment and our previous work, in which we characterized patient preferences [7] and physician variation in communication [6] of competing risks of mortality.
Coders then met to confirm a final codebook and establish a hierarchy for increasing granularity of communication: (1) not mentioned (2), name only (without risk quantification) (2), generalization (“high”) (3), average percent incidence without timepoint (4), average percent incidence with timepoint (5), precision estimate accounting for patient-level characteristics. Coders then retrospectively applied this hierarchy to the entire dataset.
Statistical analysis
The most granular mode of communication used to describe each SE throughout each consultation was described using counts/proportions. Comparisons by specialty and tumor risk were performed using the Chi-square test via Monte-Carlo simulation with 2000 replicates [8], with post-hoc Tukey’s test for pairwise comparisons, and adjustment for multiple comparisons using the Holm correction. For comparisons by specialty and tumor risk, the denominator was the total number of opportunities to discuss treatment-specific SE (e.g., for each surgical consultation, we compared communication for each surgical SE described in Fig. 1). All statistical analyses were performed using R statistical software (version 4.2.0; R Foundation, Vienna, Austria) with two-sided tests and a significance level of 0.05.
Results
The study cohort included 50 men with demographics reflective of a typical US prostate cancer population (Appendix Table 1).
Surgical SE
Surgery was discussed in 40 of 50 consultations (80%). Coders identified three discrete surgery-related SE discussed in these consultations: postoperative erectile dysfunction (ED), postoperative urinary incontinence (UI), and operative risks. Operative risks included complications in the perioperative setting and during convalescence (e.g., pain, surgical site infection, lymphocele, urine leak).
There was wide variation in the most detailed form of communication used at any point during the consultation to describe major surgical SE (Fig. 1, Appendix Table 2). For example, risk of postoperative ED was not mentioned in 15%(6/40) of consultations, mentioned in name only in 25%(10/40), generalized (e.g., “high”) in 22%(9/40), noted as an average probability with and without a timepoint in 20%(8/40) and 8%(3/40), respectively, and as a precision estimate accounting for patient-level characteristics in 10%(4/40). Similarly, risk of UI was not mentioned in 12%(5/40) of consultations, mentioned in name only in 22%(9/40), generalized in 8%(3/40), noted as an average probability with and without a timepoint in 48%(19/40) and 8%(3/40), respectively, and as a precision estimate in 2%(1/40). Operative risks were frequently omitted (68%(27/40)) or not quantified (name only, 8%(3/40), generalization, 10%(4/40)).
These modes of communication encompassed a wide range of informational quality (illustrative quotes in Table 1). When noted in name only or as a generalization, there was no numeric quantification of risk: For example, “patients do well after surgery, with minimal effect on potency.” When described as an average incidence without a timepoint, risk was articulated as an average population risk without a discrete timepoint for that risk, as in “about 50% will have some form of ED.” When described as an average incidence with a timepoint, the average risk was assigned a clear timepoint for risk, as in “less than 10% of men need a pad beyond a year.” When described as a precision estimate, risk was quantified at a timepoint and personalized based on the characteristics of the individual: “So you are super young and your [baseline] erectile function is excellent…I would say your likelihood of regaining your baseline function in a year for both continence and erectile function is upwards of like 90%.” While accuracy of numeric estimates is difficult to assess retrospectively due the many factors affecting outcomes, the numeric values when reported were heterogeneous in composition (i.e., risk of experiencing/avoiding side effect, timeline) and range (Appendix Table 3).
Radiation SE
Radiation was discussed in 36 of 50 consultations (72%). Coders identified five discrete radiation-related SE discussed in consultations: irritative lower urinary tract symptoms (LUTS), post-radiation ED, bladder and bowel bleeding, secondary malignancy, and bowel dysfunction.
There was wide variation in the most detailed form of communication used at any point during the consultation to describe major radiation SE (Fig. 1, Appendix Table 2). Major radiation-related SE of LUTS, post-radiation ED, bowel/bladder bleeding, secondary malignancy, and bowel dysfunction were not mentioned in 22%(8/36), 42%(15/36), 67%(24/36), 67%(24/36), and 64%(23/36) of consultations, respectively. These same SE were not quantified (mentioned in name only or generalized) in 61%(22/36), 33%(12/36), 22%(8/36), 28%(10/36), and 25%(9/36) of consultations, respectively. They were noted as average incidence without timeline in 8%(3/36), 22%(8/36), 8%(3/36), 0% and 6%(2/36), respectively. In only 3–8% were post-radiotherapy SE quantified with timeline (average probability with timepoint or precision estimate). A wide range of informational quality was again observed across these modes of communication (illustrative quotes in Table 1).
Variation by physician specialty and tumor risk
Concordance of physician specialty with SE increased granularity of communication (Fig. 2A), but SE were still frequently not quantified by specialty concordant physicians. When comparing all opportunities to communicate SE, surgeons and radiation oncologists failed to quantify major surgical SE 47%(34/72) and 75%(18/24) of the time (p = 0.03), respectively. Conversely, radiation oncologists and surgeons failed to quantify major radiation SE 71%(39/55) and 90%(81/90) of the time(p = 0.006). Additionally, medical oncologists never quantified surgical (0/24) or radiation (0/35) SE.
Higher tumor risk did not increase granularity of communication (Fig. 2B). When comparing all opportunities to communicate SE, major surgical SE were not quantified 71%(17/24), 67%(24/36), and 58%(33/57) of the time for very low/low-, favorable-, and unfavorable intermediate-risk disease, respectively (p = 0.5). When comparing all opportunities to communicate SE, major radiotherapy SE were not quantified 87%(26/30), 83%(50/60), and 88%(70/80) of the time for very low/low-, favorable-, and unfavorable intermediate-risk disease, respectively (p = 0.8).
Discussion
Effective communication of SE is critical for informed SDM for men with clinically localized prostate cancer. In order for patients to be full partners in SDM, they need to be informed of the risks of therapy to weigh against possible benefits in mitigating cancer progression and mortality. Indeed, information communicated by the physician has been found to be the most important factor affecting patient satisfaction with treatment decisions [9]. The challenge for the counseling physician is how to effectively articulate these risks in a meaningful, informative, and concise manner.
In this study, we found substantial variation in informational quality in communication of major treatment-related SE. At the most superficial level, we found that major SE of radical prostatectomy—ED and UI—were not mentioned in 15% and 12% of consultations, and major SE of radiotherapy—irritative urinary symptoms (LUTS), ED, bowel/bladder bleeding, secondary malignancy, and bowel dysfunction—were not mentioned in 25%, 46%, 61%, 64%, and 75% of consultations, respectively. Moreover, when these risks were articulated, there was wide variation in the amount of detail provided, ranging from no quantification (name of the SE only or a generalization as “high”/”low”) to various forms of numeric quantification (average probability without timeline (i.e., 40% risk of ED), average probability with timeline (i.e., 40% risk of ED at 1 year) or precision estimate based on individual demographics). Overall, surgical risks were quantified in only ~30% of consultations and radiation risks were quantified in only ~20% of consultations. Though the level of detail improved with specialty concordance of SE, significant variation in informational quality persisted even for specialty-concordant risks. Worse tumor risk did not increase level of detail of SE communication. These data argue for better standardization of risk communication so that patients can be adequately informed of the risks of treatment and can participate as true partners with physicians in SDM.
We created a novel, empirically derived framework for how risks of SE are typically communicated in practice. First, the name and a description of the SE are provided. This step is not trivial, as previous work has found that patients do not understand even very basic terminology related to common SE [5]. Next, a variety of methods for attributing likelihood of the event happening are used, ranging from a generalization (“high”/”low”) to a quantification of risk, most often a probability of the outcome. Finally, a timeline for the risk is attributed (e.g., “40% risk of ED at 1 year”). While some SE are assumed to be time-limited and can generally be expressed without a timeline (i.e., operative risks), most prostate cancer treatment SE either improve over time (e.g., ED), remain stable with time (e.g., radiation cystitis/bleeding), or increase with time (e.g., secondary malignancy). Omission of a timeline for risk would imply that the risk is permanent (i.e., “a 30% risk of irritative urinary symptoms after radiation therapy”).
While there is no ideal method for communicating risks of SE, we propose some common-sense recommendations for best practices. First, all major SE should at least be mentioned and briefly described. This allows patients to gauge the basic risks of each treatment option, even if risks are being described to illustrate the major conceptual disadvantages of upfront therapy (i.e., a low-risk patient considering active surveillance). Second, SE should be quantified, especially if the patient is actively considering a particular treatment option (i.e., an unfavorable intermediate-risk patient considering radiotherapy). In our study, this most often took the form of a probability of occurrence. This provides an obvious advantage over a generalization of risk, wherein a physician might describe risk as “high” or “low,” since these terms are relative and depend on how an individual values a particular outcome (i.e., a 10% risk of permanent UI requiring a pad may be “high” or “low” depending on perspective). Third, a timeline for risk should be reported, so patients can gauge whether the risk they are assuming with a particular treatment is permanent or temporary. While it may seem daunting to be able to accomplish these ideals in practice, we provide a real-life example that accomplishes all three ideals in a concise, comprehensive manner (Fig. 3).
Risks of treatment-related SE also differ by patient-specific (e.g., age, comorbidity) [10, 11], treatment-specific (e.g., fractionation of radiation) [12], and physician-specific (e.g., experience) [13] factors. While a multitude of nomograms integrating these factors exist, nomograms are not frequently used since they are cumbersome to use in practice [14]. Electronic medical record-based automated solutions for incorporation of personalized data into decision support pathways will ultimately overcome the technical limitations of incorporating nomogram-based estimates into practice [15]. In the meantime, while it would be convenient to avoid quantification of risk since estimates are flawed, we believe that providing population averages for SE—and noting how these may vary due to patient characteristics and surgeon experience—offers a reasonable estimate for the patient to consider when weighing risks and benefits of treatment. To assist clinicians, we provide a summary of population averages over time for major SE according to major prospective cohort trials (Table 2) [11, 16,17,18,19,20,21,22].
There are some limitations that should be considered when interpreting our findings. First, the reported frequencies for SE communication may not represent population averages since our data were limited to a single tertiary referral center. However, measuring quality of communication among fellowship-trained, board-certified physicians who knew they were being recorded would tend to minimize rather than exaggerate our observed findings. Second, the number of consultations within some tumor risk subgroups was low, so quantitative comparisons of these groups may be underpowered to detect smaller differences. Third, numerous factors including health numeracy and literacy may affect how physicians communicate risk; our observations are based on our patient sample that is largely well educated.
Conclusions
Physician communication of prostate cancer treatment-related SE varies widely in terms of informational quality. We created a framework for how SE are currently communicated and made common sense recommendations for how SE should be ideally communicated, emphasizing disclosure and description of all major SE for treatments under consideration, providing numeric quantification and a timeline for the risk. Our work argues for greater standardization and monitoring of the SE data communicated in consultations so that patients can be sufficiently informed of potential risks. Indeed, we feel that adequate communication of these risks—mentioning all major SE and ideally quantifying them—should be audited as a marker of quality of care. Ensuring adequate patient education about risks (and rewards) of therapy is the only conceivable way that patients can engage as fully informed partners in SDM.
Data availability
Requests for data will be evaluated by the study team on a case-by-case basis.
References
Eastham JA, Auffenberg GB, Barocas DA, Chou R, Crispino T, Davis JW, et al. Clinically localized prostate cancer: AUA/ASTRO guideline, Part I: Introduction, risk assessment, staging, and risk-based management. J Urol. 2022;208:10–8. https://doi.org/10.1097/JU.0000000000002757.
Hoffmann TC, Montori VM, Del Mar C. The connection between evidence-based medicine and shared decision-making. JAMA. 2014;312:1295–6. https://doi.org/10.1001/jama.2014.10186.
Montori VM, Brito JP, Murad MH. The optimal practice of evidence-based medicine: incorporating patient preferences in practice guidelines. JAMA. 2013;310:2503–4. https://doi.org/10.1001/jama.2013.281422.
Litwin MS, Tan HJ. The diagnosis and treatment of prostate cancer: a review. JAMA. 2017;317:2532–42. https://doi.org/10.1001/jama.2017.7248.
Wang DS, Jani AB, Sesay M, Tai CG, Lee DK, Echt KV, et al. Video-based educational tool improves patient comprehension of common prostate health terminology. Cancer. 2015;121:733–40. https://doi.org/10.1002/cncr.29101.
Daskivich TJ, Gale R, Luu M, Naser-Tavakolian A, Venkataramana A, Khodyakov D, et al. Variation in communication of competing risks of mortality in prostate cancer treatment consultations. J Urol. 2022. https://doi.org/10.1097/JU.0000000000002675.
Daskivich TJ, Gale R, Luu M, Khodyakov D, Anger JT, Freedland SJ, et al. Patient preferences for communication of life expectancy in prostate cancer treatment consultations. JAMA Surg. 2021. https://doi.org/10.1001/jamasurg.2021.5803.
Hope ACA. A simplified Monte Carlo significance test procedure. J R Stat Soc. 1968;30:582–298.
Gilbert SM, Sanda MG, Dunn RL, Greenfield TK, Hembroff L, Klein E, et al. Satisfaction with information used to choose prostate cancer treatment. J Urol. 2014;191:1265–71. https://doi.org/10.1016/j.juro.2013.12.008.
Daskivich TJ, van de Poll-Franse LV, Kwan L, Sadetsky N, Stein DM, Litwin MS. From bad to worse: comorbidity severity and quality of life after treatment for early-stage prostate cancer. Prostate Cancer Prostatic Dis. 2010;13:320–7. https://doi.org/10.1038/pcan.2010.33.
Barocas DA, Alvarez J, Resnick MJ, Koyama T, Hoffman KE, Tyson MD, et al. Association between radiation therapy, surgery, or observation for localized prostate cancer and patient-reported outcomes after 3 years. JAMA. 2017;317:1126–40. https://doi.org/10.1001/jama.2017.1704.
Morgan SC, Hoffman K, Loblaw DA, Buyyounouski MK, Patton C, Barocas D, et al. Hypofractionated radiation therapy for localized prostate cancer: an ASTRO, ASCO, and AUA evidence-based guideline. J Clin Oncol. 2018:JCO1801097. https://doi.org/10.1200/JCO.18.01097.
Hu JC, Gold KF, Pashos CL, Mehta SS, Litwin MS. Role of surgeon volume in radical prostatectomy outcomes. J Clin Oncol. 2003;21:401–5.
Ross RW, Kantoff PW. Predicting outcomes in prostate cancer: how many more nomograms do we need? J Clin Oncol. 2007;25:3563–4. https://doi.org/10.1200/JCO.2007.12.2721.
Tan HJ, Zhou X, Spratte BN, McMahon S, Nielsen ME, Lund J, et al. Patient reported vs claims based measures of health for modeling life expectancy in men with prostate cancer. J Urol. 2021;205:434–40. https://doi.org/10.1097/JU.0000000000001355.
Barocas DA, Chen V, Cooperberg M, Goodman M, Graff JJ, Greenfield S, et al. Using a population-based observational cohort study to address difficult comparative effectiveness research questions: the CEASAR study. J Comp Eff Res. 2013;2:445–60. https://doi.org/10.2217/cer.13.34.
Resnick MJ, Koyama T, Fan KH, Albertsen PC, Goodman M, Hamilton AS, et al. Long-term functional outcomes after treatment for localized prostate cancer. N Engl J Med. 2013;368:436–45. https://doi.org/10.1056/NEJMoa1209978.
Sanda MG, Dunn RL, Michalski J, Sandler HM, Northouse L, Hembroff L, et al. Quality of life and satisfaction with outcome among prostate-cancer survivors. N Engl J Med. 2008;358:1250–61. https://doi.org/10.1056/NEJMoa074311.
Stanford JL, Feng Z, Hamilton AS, Gilliland FD, Stephenson RA, Eley JW, et al. Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer: the prostate cancer outcomes study. JAMA. 2000;283:354–60. https://doi.org/10.1001/jama.283.3.354.
Potosky AL, Davis WW, Hoffman RM, Stanford JL, Stephenson RA, Penson DF, et al. Five-year outcomes after prostatectomy or radiotherapy for prostate cancer: the prostate cancer outcomes study. J Natl Cancer Inst. 2004;96:1358–67. https://doi.org/10.1093/jnci/djh259.
Bagshaw HP, Arnow KD, Trickey AW, Leppert JT, Wren SM, Morris AM. Assessment of second primary cancer risk among men receiving primary radiotherapy vs surgery for the treatment of prostate cancer. JAMA Netw Open. 2022;5:e2223025 https://doi.org/10.1001/jamanetworkopen.2022.23025.
Hamilton AS, Stanford JL, Gilliland FD, Albertsen PC, Stephenson RA, Hoffman RM, et al. Health outcomes after external-beam radiation therapy for clinically localized prostate cancer: results from the prostate cancer outcomes study. J Clin Oncol. 2001;19:2517–26. https://doi.org/10.1200/JCO.2001.19.9.2517.
Acknowledgements
This work was supported by a Career Development Award (K08 CA230155 to TJD) from the National Cancer Institute.
Funding
Open access funding provided by SCELC, Statewide California Electronic Library Consortium.
Author information
Authors and Affiliations
Contributions
The role(s) of each author in the manuscript are as follows: Conception and design: TJD. Acquisition of data including coding: RG, ANT, NF, AV. Analysis and interpretation of data: TJD, ML, BS, SJF. Drafting the manuscript: TJD, ANT, ML. Critical revision of the manuscript for important intellectual content: ANT, DK, EP, HS, BS, SJF. Statistical analysis: ML. Obtaining funding: TJD. Administrative, technical, or material support: RG. Supervision: TJD.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Daskivich, T.J., Naser-Tavakolian, A., Gale, R. et al. Variation in communication of side effects in prostate cancer treatment consultations. Prostate Cancer Prostatic Dis (2024). https://doi.org/10.1038/s41391-024-00806-2
Received:
Revised:
Accepted:
Published:
DOI: https://doi.org/10.1038/s41391-024-00806-2
This article is cited by
-
Prostatectomy in oligometastatic prostate cancer: a call for high-quality evidence
Prostate Cancer and Prostatic Diseases (2024)