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Cell type and sex specific insights into ventral striatum deep brain stimulation for cocaine relapse

Neuropsychopharmacology volume 48, pages 434–435 (2023)Cite this article

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Relapse continues to be a major problem for stimulant use disorder. Neuromodulation with tools like deep brain stimulation (DBS) is currently being explored as a potential treatment [1]. Since it was FDA-approved for the treatment of Parkinson’s disease more than two decades ago, DBS has emerged as a promising approach for otherwise intractable neuropsychiatric illnesses [2]. DBS currently has a humanitarian device exemption status from the FDA for the treatment of compulsive disorders like refractory obsessive-compulsive disorder and Tourette’s syndrome [2]. This suggests that DBS may also become a valuable tool in treating substance use disorders (SUDs) [1].

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Funding

This work was supported by NIDA-R00-DA048085 and NIAAA-UG3-AA030505 to KM.

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  1. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA

    Collin M. Lehmann & Khaled Moussawi

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  1. Collin M. Lehmann
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  2. Khaled Moussawi
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CML and KM wrote the initial draft and approved the final version of the commentary.

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Correspondence to Khaled Moussawi.

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The authors declare no competing interests.

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Lehmann, C.M., Moussawi, K. Cell type and sex specific insights into ventral striatum deep brain stimulation for cocaine relapse. Neuropsychopharmacol. 48, 434–435 (2023). https://doi.org/10.1038/s41386-022-01513-z

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