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Stem cell transplantation

P2X7 polymorphisms and stem cell mobilisation

Leukemia volume 32, pages 2724–2726 (2018)Cite this article

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We have recently read with interest the findings of Ratajczak et al. (Leukemia 2018 March eprint [1]) in which the genetic loss of P2X7 in a knock out mouse strain led to reduced stem cell mobilisation following G-CSF administration.

In humans P2X7 expression, loss or gain of function and disease associations is variously influenced by the inheritance of various P2X7 single nucleotide polymorphisms (SNPs). For example, the polymorphism Ile568Asn results in reduced phagocytosis by macrophages [2], whereas the Arg307Gln polymorphism results in a decreased inflammasome response [3]. Conversely, some polymorphisms are associated with increased P2X7 activity, such as the Ala348Thr polymorphism, which results in a threefold increase in activity compared to wild type. Furthermore, when Ala348Thr is co-inherited with Gln460Arg as haplotype 4 the activity of P2X7 is further amplified to fivefold that of those not carrying this haplotype [4].

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Acknowledgements

This research was supported by Fight Cancer Foundation.

Author contributions

RK designed the study, performed the analysis and wrote the manuscript. JC sourced the clinical information. DR designed the study and wrote the manuscript.

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Authors and Affiliations

  1. ACRF Translational Research Laboratory, Royal Melbourne Hospital, Melbourne, Australia

    Rachel Koldej, Jenny Collins & David Ritchie

  2. Department of Medicine, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia

    Rachel Koldej & David Ritchie

  3. Department of Haematology and BMT, Royal Melbourne Hospital, Melbourne, Australia

    Jenny Collins & David Ritchie

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  1. Rachel Koldej
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Correspondence to Rachel Koldej.

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Koldej, R., Collins, J. & Ritchie, D. P2X7 polymorphisms and stem cell mobilisation. Leukemia 32, 2724–2726 (2018). https://doi.org/10.1038/s41375-018-0232-8

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