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Placental pathology associated with lenticulostriate vasculopathy (LSV) in preterm infants

Journal of Perinatology volumeĀ 43,Ā pages 568ā€“572 (2023)Cite this article

Subjects

Abstract

Objective

Our aim was to examine the frequency and type of placental abnormalities in neonates with LSV.

Study design

We prospectively reviewed cranial ultrasounds (cUS) from neonates born at ā‰¤32 weeks of gestation at Parkland Hospital between 2012 and 2014. Our cohort included neonates with LSV and gestational age and sex matched controls with normal cUS. We retrieved placental pathology reports retrospectively and compared placental abnormalities in both groups.

Results

We reviewed 1351 cUS from a total of 407 neonates. Placental pathology evaluations were complete for 64/65 (98%) neonates with LSV and 68/70 (97%) matched controls. There were no significant differences for any type of placental abnormities between LSV and control groups. However, infants with highest stage LSV were more likely to have large for gestational age (LGA) placentas (pā€‰=ā€‰0.01).

Conclusion

The association between LSV and LGA placenta may indicate a shared vascular response to an adverse prenatal environment.

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Data availability

The datasets analyzed during the current study are available from the corresponding author on reasonable request and may require institutional data agreements.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Julide Sisman,Ā Rachel L. Leon,Ā Brooke W. PaytonĀ &Ā Imran N. Mir

  2. Department of Health System Research, Parkland Health and Hospital System, Dallas, TX, USA

    L. Steven Brown

Authors
  1. Julide Sisman
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  2. Rachel L. Leon
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  3. Brooke W. Payton
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  4. L. Steven Brown
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  5. Imran N. Mir
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Contributions

Dr. Sisman, conceptualized and designed the study, drafted the initial manuscript, reviewed and revised the manuscript. Dr. Leon, BP, NNP and SB, MS collected data, carried out analysis, reviewed and revised the manuscript. Dr. Mir conceptualized and design the study, coordinated and supervised data collection, and critically reviewed the manuscript. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

Corresponding author

Correspondence to Julide Sisman.

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The authors declare no competing interests.

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Sisman, J., Leon, R.L., Payton, B.W. et al. Placental pathology associated with lenticulostriate vasculopathy (LSV) in preterm infants. J Perinatol 43, 568ā€“572 (2023). https://doi.org/10.1038/s41372-022-01557-5

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