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Placental pathology and intraventricular hemorrhage in preterm and small for gestational age infants

Journal of Perinatology volume 41, pages 843–849 (2021)Cite this article

Subjects

Abstract

Objective:

The aim of this study was to examine the relationship between chorioamnionitis and vascular malperfusion on placental pathology and intraventricular hemorrhage (IVH) in premature and small for gestational age (SGA) infants.

Study design:

A retrospective analysis of 263 infants ≤34 weeks gestation or ≤1800 g and their mothers was conducted by chart review for placental pathology and clinical data from 2014 to 2018. Unadjusted and adjusted odds ratios (OR) for the association of placental pathology with IVH were calculated.

Result:

Unadjusted OR showed an association between acute chorioamnionitis and IVH, but logistic regression analysis showed a non-significant adjusted OR between acute or chronic chorioamnionitis with IVH. Maternal vascular malperfusion was significantly associated with increased IVH when controlling for confounders.

Conclusion:

Placental maternal vascular malperfusion is associated with the development of IVH in premature and SGA infants when controlling for other confounders.

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Fig. 1: Inclusion and exclusion criteria of infants.

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Author information

Author notes

  1. Melissa A. Oh

    Present address: Department of Pediatrics, Division of Neonatology, Beverly Knight Olson Children’s Hospital Navicent Health, Macon, GA, USA

  2. Mohamed Mohamed

    Present address: Department of Neonatology, The Pediatrics Institute Cleveland Clinic Children’s, Cleveland, OH, USA

  3. Anna A. Penn

    Present address: Department of Pediatrics, Division of Neonatology, NYP- Morgan Stanley Children’s Hospital, Columbia University, New York, NY, USA

  4. These authors contributed equally: Mohamed Mohamed, Anna A. Penn.

Authors and Affiliations

  1. Department of Neonatology, Children’s National Hospital, Washington, DC, USA

    Melissa A. Oh

  2. Department of Pathology and Laboratory Medicine, The George Washington University Hospital, Washington, DC, USA

    Stephanie Barak

  3. Department of Obstetrics and Gynecology, The George Washington University Hospital, Washington, DC, USA

    Mohamed Mohamed

  4. Department of Neonatology, Children’s National Hospital, Washington, DC, USA

    Anna A. Penn

Authors
  1. Melissa A. Oh
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Contributions

MAO contributed to the concept and design of the study, performed chart review/data collection, performed data analysis, and wrote the manuscript. SB contributed to the concept and design of the study, performed placental pathology data review, and revised the manuscript. MM contributed to the design of the study, performed data analysis, and helped write the manuscript. AAP contributed to the concept and design of the study and revised the manuscript.

Corresponding author

Correspondence to Melissa A. Oh.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval and consent to participate

The George Washington University Committee on Human Research International Review Board (IRB) approved this study (IRB# 041826). The study was performed in accordance with the Declaration of Helsinki.

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Oh, M.A., Barak, S., Mohamed, M. et al. Placental pathology and intraventricular hemorrhage in preterm and small for gestational age infants. J Perinatol 41, 843–849 (2021). https://doi.org/10.1038/s41372-021-00954-6

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  • DOI: https://doi.org/10.1038/s41372-021-00954-6

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