The effects of Necdin, a ligand of neurotrophin receptors, on the susceptibility of neuroblastoma cells to oxidative stress appear to be modified by the cellular p75NTR:TrkA ratio.
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In newborn mice, stress affected hippocampal gene expression. Morphine administration modified this effect, while influencing genes not affected by stress.
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Human hIL-1β overexpression in mice during the saccular stage of lung development might be sufficient to cause lung abnormalities similar to bronchopulmonary dysplasia.
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Adjusted positive end-expiratory pressure during high frequency jet ventilation seems to improve oxygenation and lung compliance in preterm lambs and to reduce ventilator requirements despite reducing pulmonary perfusion.
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Plasma renin activity and aldosterone levels are shown to be inversely related to 24-hour blood pressure in obese adolescents.
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In a case control study, children with Rett syndrome sustained more low-energy fractures than controls, while overall fracture incidence was not increased.
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Editor's Focus. Pediatr Res 69, 5 (2011). https://doi.org/10.1203/PDR.0b013e318215be9d
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DOI: https://doi.org/10.1203/PDR.0b013e318215be9d